Ciraparantag (aripazine) is a drug under investigation as an antidote for a number of anticoagulant (anti-blood clotting) drugs, including factor Xa ...
Ciraparantag (previously, aripazine; PER977; Perosphere Inc Danbury, CT) is a synthetic, small water-soluble molecule that has been developed as a reversal ...
Ciraparantag, an anticoagulant reversal agent with broad activity, binds directly to anticoagulant molecules including DOACs, enoxaparin and unfractionated ...
Background: Ciraparantag is in clinical development as a reversal agent for various anticoagulants including non-vitamin K oral anticoagulants (NOACs).
Ciraparantag, also known as PER977, is a small molecule reversal agent for new oral anticoagulants and heparins. PER977 is a water-soluble, ...
#11.
Ciraparantag, an Anticoagulant Reversal Drug: Mechanism of ...
Ciraparantag given after the bleeding injury also significantly reduces blood loss. Ciraparantag appears to have substantial ability to reduce blood loss in ...
#12.
ciraparantag - Wikidata
ciraparantag. small molecule drug that is under investigation as a potential antidote for multiple anticoagulants, including factor Xa inhibitors.
#13.
Ciraparantag as a potential universal anticoagulant reversal ...
This editorial refers to 'Ciraparantag reverses the anticoagulant activity of apixaban and rivaroxaban in healthy elderly subjects' by J. Ansell et al., ...
#14.
Ciraparantag, an anticoagulant reversal drug - Europe PMC
Ciraparantag, an anticoagulant reversal agent, is a small molecule specifically designed to bind noncovalently by charge-charge interaction to ...
#15.
Ciraparantag (trifluoroacetate salt) - Cayman Chemical
Ciraparantag is an anticoagulant reversal agent. It selectively binds to unfractionated heparin, enoxaparin, and Factor IXa (Kds = 28, 17, and 35 µM, ...
Ciraparantag is an intravenously-administered, water soluble, small molecule, anticoagulant reversal agent being developed by Perosphere (a subsidiary of ...
#17.
Ciraparantag Completed Phase 2 Trials for Anticoagulation ...
NCT02207257, Study of PER977 Administered to Subjects With Steady State Edoxaban Dosing and Re-anticoagulation With Edoxaban. Ciraparantag (DB15199) ...
#18.
CIRAPARANTAG ACETATE - Inxight Drugs
In April 2015, ciraparantag received FDA fast-track designation as an investigational anticoagulant reversal agent. Phase I/II trials are currently underway to ...
#19.
Ciraparantag Reverses Apixaban and Rivaroxaban Activity in ...
Ciraparantag is a synthetic, water-soluble molecule that exerts its effects by binding directly to anticoagulants through non-covalent hydrogen ...
#20.
Twitter 上的 Henry Han , MBBS, MD："Ciraparantag :Novel ...
Ciraparantag :Novel Universal anticoagulant reversal agent #Ciraparantag provides a dose-related reversal of anticoagulation Sustained ...
#21.
New data in the European Heart Journal show ciraparantag ...
Ciraparantag is a novel small, water-soluble molecule being investigated for reversal of anticoagulation induced by direct oral anticoagulants ( ...
#22.
PER977 (ciraparantag) reverses edoxaban anticoagulation at ...
Related trials · Study of PER977 Administered to Subjects With Steady State Edoxaban Dosing and Re-anticoagulation With Edoxaban · Single-dose ciraparantag safely ...
#23.
Ciraparantag - OEL Fastrac with ADE - Affygility Solutions
Ciraparantag (PER97, arapazine) is an investigational drug in clinical development as a reversal agent for new oral anticoagulants and heparins.
#24.
Single-dose ciraparantag safely and ... - Thieme Connect
Ciraparantag, edoxaban, anticoagulant, reversal, whole blood clotting time. Correspondence to: James C. Costin, MD. Perosphere, Inc. 20 Kenosia Ave.
#25.
Ciraparantag TM-T10820 - CymitQuimica
Ciraparantag is an inhibitor of thrombin and factor Xa. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including unfractionated heparin ...
Ciraparantag, also called as PER977, a synthetic, cationic small molecule, has potential to be a simple, inexpensive universal anticoagulation reversal ...
#28.
Ciraparantag - DocCheck Flexikon
Ciraparantag ist ein noch (2021) in Entwicklung bedindlicher Arzneistoff, der bei Überdosierungen von Faktor-Xa-Hemmern (Rivaroxaban, Apixaban, Edoxaban), ...
#29.
New data in the European Heart Journal show ciraparantag
Ciraparantag is a novel small, water-soluble molecule being investigated for reversal of anticoagulation induced by direct oral anticoagulants ( ...
#30.
Paper: Reversal of Anticoagulation By Ciraparantag
Ciraparantag, an anticoagulant reversal agent with broad activity, binds directly to anticoagulant molecules including direct oral ...
#31.
role of ciraparantag, andexanet alfa, and idarucizumab
Vascular Health and Risk Management · Reversing anticoagulant effects of novel oral anticoagulants: role of ciraparantag, andexanet alfa, and ...
#32.
Single-dose ciraparantag safely and ... - Medscape Education
Escalating, single IV doses of ciraparantag were administered alone and following a 60 mg oral dose of edoxaban in a double-blind, placebo-controlled fashion to ...
Product Name, Ciraparantag(PER977). Catalog Number, orb341522. Hazard Information, Non-Toxic. Alternative Names, (click to expand) PER977, Aripazine,PER-977 ...
#35.
Ciraparantag Clinical Trials 2023 - Clincosm
ciraparantag ; Recruiting · South Miami, Florida · Feb 18, 2022 ; Completed · Secaucus, New Jersey · Sep 2, 2020 ; Completed · Secaucus, New Jersey · Sep 1, 2020 ...
#36.
Ciraparantag的搜索结果-临床试验注册中心 - ICH GCP
Ciraparantag 的临床试验。临床试验注册。 ICH GCP。
#37.
Ciraparantag effectively reverses anticoagulantion with ...
Ciraparantag is a small synthetic molecule that binds directly to direct factor Xa inhibitors, direct thrombin inhibitors, ...
#38.
Ciraparantag for enoxaparin reversal: Adding to the evidence
Ciraparantag for enoxaparin reversal: Adding to the evidence Academic Article uri icon. View record in Web of Science ®.
#39.
Ciraparantag - Horizonscan geneesmiddelen
Extended indication, Antagonist antistollingsmiddelen, zowel DOACs als LMWH. Therapeutic value, Possible added value. Total cost, € 1,675,000.00.
#40.
Amag merges with Perosphere, adding NOAC antidote
Perosphere says ciraparantag is different to current reversal agents—which at the moment consist of Portola's AndexXa for Xarelto and Eliquis and Boehringer ...
#41.
75: When will the FDA approve ciraparantag / PER977?
Ciraparantag or PER977 is a broad spectrum anticoagulant reversal agent under fast track review at the FDA. Ciraparantag is reported to ...
#42.
Ciraparantag - AllgenBio
Ciraparantag (free base), also known as PER977, is a small molecule reversal agent for new oral anticoagulants and heparins. PER977 is a water-soluble, ...
#43.
Ciraparantag for enoxaparin reversal: Adding to the evidence
Ciraparantag is a synthetic, cationic small molecule that was initially developed to reverse heparin, low-molecular-weight heparin and ...
Ciraparantag is a thrombin and factor Xa inhibitors as well as to heparin-based anticoagulants through non-covalent hydrogen bonding and charge interactions ...
#48.
A short review of ciraparantag in perspective of the currently ...
Ciraparantag, a synthetic small molecule that inactivates heparins and DOAC, is a promising new reversal agent that has been investigated in phase 2 trials. In ...
#49.
Covis Group Announces Data for Ciraparantag ... - PR Newswire
Ciraparantag is a novel small, water-soluble molecule being investigated for reversal of anticoagulation induced by direct oral anticoagulants ( ...
#50.
Reversing anticoagulant effects of novel oral anticoagulants
Ciraparantag (PER977, Perosphere, Danbury, CT, USA) is a small synthetic and cationic molecule that binds direct Xa inhibitors, direct thrombin ...
#52.
Ciraparantag, CAS [[1438492-26-2]] Preis auf Anfrage | BIOZOL
Ciraparantag is an inhibitor of thrombin and factor Xa. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including unfractionated heparin ...
#53.
Ciraparantag - New Drug Approvals
Ciraparantag, also known as PER977, is a A Small Molecule Reversal Agent for New Oral Anticoagulants and Heparins. PER977 is water-soluble, ...
#54.
[논문]Single-dose ciraparantag safely and completely ...
We assessed the safety, tolerability and impact on anticoagulation reversal of ciraparantag (PER977) alone and following a 60 mg dose of the FXa inhibitor ...
#55.
Ciraparantag - Wikiwand
Ciraparantag is a drug under investigation as an antidote for a number of anticoagulant drugs, including factor Xa inhibitors , dabigatran, and heparins ...
#57.
AMAG Pharmaceuticals and Norgine B.V. Enter Into Exclusive ...
Ciraparantag is in development for use in patients treated with direct oral anticoagulants (DOACs) and low molecular weight heparin (LMWH) when ...
#58.
CIRAPARANTAG ACETATE
STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL. USAN (bc-148). CIRAPARANTAG ACETATE. PRONUNCIATION sir'' a par' an tag.
#59.
Reversal of Direct Oral Anticoagulants - HealthManagement.org
Ciraparantag provides a dose-related reversal of anticoagulation induced by steady-state dosing of apixaban or rivaroxaban. All doses of ciraparantag were well ...
#60.
perosphere pharmaceuticals - SEC.gov
Ciraparantag is a small molecule anticoagulant reversal agent which is believed to bind to NOACs such as Xarelto®(rivaroxaban), ...
#62.
AMAG to Acquire Ciraparantag Maker Perosphere ... - Nasdaq
Ciraparantag is an anticoagulant reversal agent. The candidate is currently being evaluated in a phase IIb study on patients, treated with ...
#63.
role of ciraparantag, andexanet alfa, and idarucizumab ... - Gale
Two other antidotes, andexanet alfa (PRT064445) and ciraparantag (PER977) are also under development for reversal of NOACs. In this review, we discuss ...
#64.
Idarucizumab review video abstract 89130 - YouTube
Video abstract of review paper “Reversing anticoagulant effects of novel oral anticoagulants: role of ciraparantag, andexanet alfa, ...
#65.
Progressing Toward Reversing Factor Xa Inhibitor ... - HCPLive
Additionally, ciraparantag (PER977, Perosphere) is in phase 2 trials as an antidote to both oral FXa inhibitor anticoagulants and ...
#66.
Table 2 - BLOOD RESEARCH
LMWH, Renal excretion, 4 hours, Protamine sulfate (ciraparantag a) ). VKA, Hepatic metabolism, 40 hours, Oral or IV Vitamin K. Fresh frozen plasma.
#67.
AMAG flies on news of deal to commercialize ciraparantag
Ciraparantag is in development for use in patients treated with direct oral anticoagulants (DOACs) and low molecular weight heparin (LMWH) ...
#68.
role of ciraparantag, andexanet alfa, and idarucizumab
Two other antidotes, andexanet alfa (PRT064445) and ciraparantag (PER977) are also under development for reversal of NOACs. In this review, we discuss ...
#69.
Perosphere Pharmaceuticals' Ciraparantag Research ...
Perosphere Pharmaceuticals Inc. today announced the presentation of clinical study results demonstrating, "Ciraparantag Safely and ...
#70.
ciraparantag
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#71.
Private equity-backed Covis to buy AMAG Pharma in $650M ...
Currently in Phase 2 testing, ciraparantag is a reversal agent for blood thinners like Xarelto and Eliquis. Ami Fadia, an analyst at SVB Leerink ...
#72.
Management of Bleeding With Non–Vitamin K Antagonist Oral ...
ciraparantag have been reported to reverse the effects of the anti-Xa. NOACs (rivaroxaban, apixaban, and edoxaban), and a number of other.
#73.
AMAG Pharmaceuticals Completes Acquisition of Perosphere
Ciraparantag has been granted Fast Track review designation by the US Food and Drug Administration (FDA) and has composition of matter patent protection until ...
#74.
First antidote for reversal of anticoagulation with factor Xa ...
This medicine is to be used as an antidote for adult patients taking the anticoagulant (clot-preventing) medicines apixaban or rivaroxaban, when ...
#75.
SPECIFIC ANTIDOTES FOR DIRECT ORAL ... - ThaiJO
Lastly, ciraparantag, the universal antidote which reverses effects of both factor Xa inhibitors and factor IIa inhibitors, ...
#76.
Journals on the Web
A third emerging universal reversal agent is ciraparantag (PER- 977, aripazine or diarginine piperazine), a small cationic molecule that binds to unfractionated ...
#78.
Current Evidence for Pharmacologic Reversal using Direct ...
Ciraparantag (Perosphere Inc, Danbury, Conn), a general reversal agent that is active against both direct and indirect factor Xa inhibitors, ...
#79.
DOAC management: reversal options with case study discussion
Reversal options, pharmacology and evidence. ◦ Supportive care and current practice. ◦ Idarucizumab (Praxbind). ◦ Andexanet alfa. ◦ Ciraparantag.
#80.
New Drugs and Technologies
(ciraparantag), a synthetic small molecule that is reported to bind to all of the NOACs and has been shown to reduce the.
#81.
Ciraparantag safely and completely reverses the ... - J-Global
Article “Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin” Detailed information of the J-GLOBAL is a ...
#82.
Reversal Strategies for Intracranial Hemorrhage Related to ...
... but others (andexanet-α and ciraparantag) may be approved in near future, and the development and availability of such reversal agents have the ...
#84.
Ciraparatang : un nouvel antidote des AOD et des héparines ...
Ciraparantag, an anticoagulant reversal agent, is a small molecule specifically designed to bind non-covalently by charge-charge interaction to ...
#85.
Preclinical and Clinical Data for Factor Xa and ``Universal ...
decoy molecule, is in a late-phase clinical trial in bleeding patients, and ciraparantag, a small molecule that appears to reverse many anticoagulants ...
#86.
Ciraparantag clinical trial progress and patents: Drug pipeline ...
Phase 2 Study of Apixaban Reversal by Ciraparantag as Measured by WBCT, Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.
#87.
Amag buyers bet big on reversal agent - Evaluate Pharma
Ciraparantag is a reversal agent believed to be active against heparin as well as the novel, oral anticoagulants Pradaxa, Eliquis, ...
#88.
Single-dose ciraparantag safely and completely reverses ...
Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban. Ansell JE et al. Thrombosis and Haemostasis.
#90.
Ciraparantag safely and completely reverses the ...
We studied the ability of ciraparantag (PER977), a novel agent that reverses LMWH in preclinical studies, to reverse LMWH in healthy volunteers.
#91.
Phase 2 Study of Apixaban Reversal by Ciraparantag as ...
This study is a randomized, single-blind, placebo-controlled study to assess the efficacy and safety of ciraparantag administered to healthy volunteers ...
#92.
Manejo de hemorragia asociada a anticoagulantes orales ...
En ensayos ex-vivo y en modelos animales de sangrado el ciraparantag ha demostrado reversión del efecto anticoagulante del dabigatrán y de los inhibidores del ...
#93.
ciraparantag - Diccionari enciclopèdic de medicina (DEMCAT ...
ca ciraparantag, n m; es ciraparantag; fr ciraparantag; en ciraparantag; CAS 1438492-26-2 .FITXA MODIFICADA, Farmacologia > Fàrmacs ...
#94.
Reversal of direct oral anticoagulants - Mendeley
... and Drug Administration to reverse the effects of dabigatran; andexanet alfa and ciraparantag are also under evaluation as reversal agents for DOACs.
#95.
ciraparantag - معنی در دیکشنری آبادیس
معنی ciraparantag - معانی، کاربردها، تحلیل، بررسی تخصصی، جمله های نمونه، مترادف ها و متضادها و ... در دیکشنری آبادیس - برای مشاهده کلیک کنید.
#96.
Transfusion Practice in Clinical Neurosciences
Both ciraparantag and its metabolites are recovered almost entirely in the urine 2 h after its administration. SuperFVa has been shown to reverse bleeding ...
#97.
Neuropharmacotherapy in Critical Illness - Google 圖書結果
... a real-world setting.85,86 Ciraparantag (PER977) Ciraparantag (previously ... bonding to neutralize their activity.86 Ciraparantag binds to UFH, LMWH, ...
ciraparantag 在 Idarucizumab review video abstract 89130 - YouTube 的推薦與評價
Video abstract of review paper “Reversing anticoagulant effects of novel oral anticoagulants: role of ciraparantag, andexanet alfa, ... ... <看更多>