關於 clostridium difficile treatment ，我們在網路上蒐集到這些相關的討論、資訊與評價

不能因為「抗生素」三個字而下定論

困難梭狀桿菌感染(CDI)是由於長期服用抗生素造成腸道菌相改變，使困難梭狀桿菌有機會大量複製且分泌毒素進而造成腸道發炎。科學家現研發出一種新型抗生素 Ramizol，動物實驗證實可有效抑制CDI，在藥物安全性研究中，經連續14天向48隻感染困難梭狀桿菌的大鼠注射高劑量的 Ramizol，沒有產生嚴重的副作用或體重變化，對動物而言是一種耐受性良好的抗生素，未來將有望用於人類CDI治療。

[1]Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis. J Antibiot (Tokyo). (2016)

[2]Comparison of the in vitro antibacterial activity of Ramizol, fidaxomicin, vancomycin, and metronidazole against 100 clinical isolates of Clostridium difficile by broth microdilution. Diagnostic Microbiology and Infectious Disease. (2018)

潘老師於10月份中廣蘭萱節目中所引用的資料來源為2013年9月12日的ABC新聞網一則新聞：

要提醒大家，此篇新聞引用的是臨床醫師的個案報告資料
並非嚴謹的研究報告，因此是否適用在您或您的親朋好友身上，有待商榷。

但這是一個可以與醫師討論的治療方向之一
隨信附上此篇新聞中提及的檢驗項目名稱以及新聞完整內容
請您務必攜帶此份文件與醫師共同討論。
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附上給聽眾的資料兩份(原文資料)如下，
希望資料對各位聽眾有幫助。
1.http://abcnews.go.com/Health/anxiety-head-gut/story…
2.http://www.ncbi.nlm.nih.gov/pubmed/20423563
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HPHPA檢驗
3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) 羥基丙酸(丙醇酸)，屬於酪胺酸 (Tyrosine)代謝的副產物，用來檢驗體內梭狀桿菌的數量是否過多

Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia.
Shaw W.
Source
The Great Plains Laboratory, Inc., Lenexa, Kansas 66214, USA. williamsha@aol.com
Abstract
A compound identified as 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) was found in higher concentrations in urine samples of children with autism compared to age and sex appropriate controls and in an adult with recurrent diarrhea due to Clostridium difficile infections. The highest value measured in urine samples was 7500 mmol/mol creatinine, a value 300 times the median normal adult value, in a patient with acute schizophrenia during an acute psychotic episode. The psychosis remitted after treatment with oral vancomycin with a concomitant marked decrease in HPHPA. The source of this compound appears to be multiple species of anaerobic bacteria of the Clostridium genus. The significance of this compound is that it is a probable metabolite of m-tyrosine (3-hydroxyphenylalanine), a tyrosine analog which depletes brain catecholamines and causes symptoms of autism (stereotypical behavior, hyperactivity, and hyper-reactivity) in experimental animals

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