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#1. A guide to assessing cellular senescence in vitro and in vivo
Cellular senescence is a complex cell response to damage and stress that can ... The use of the so-called senescence reporter mice has been ...
#2. Generation of a p16 Reporter Mouse and Its Use to ... - PubMed
Cell senescence plays a key role in age-associated organ dysfunction, but the in vivo pathogenesis is largely unclear. Here, we generated a ...
#3. Real-time imaging of senescence in tumors with DNA damage
Detection of cellular senescence is important not only in the study of senescence ... owing to the widespread utility of reporter gene LacZ, ...
#4. Article Generation of a p16 Reporter Mouse and Its Use to ...
Despite their importance in aging, the localization in tissues, physiological function, and dynamics in vivo of senescent cells remain to be ...
#5. The miR-146a-EGFP Reporter Detects Senescence in ...
Cancer cells can also undergo senescence, but the stresses that provoke cancer ... inserted the reporter gene in A375 melanoma cells and induced senescence ...
#6. p16-3MR: A Novel Model to Study Cellular ... - MDPI
p16-3MR mice have a trimodal reporter fused to the promoter of the p16INK4a gene that enables detection, isolation, and selective elimination of ...
#7. Senescence & Reporter Gene Assay - Dojindo EU GmbH
Senescence & Reporter Gene Assay · Cellular Senescence Detection Kit - SPiDER-ßGal Cellular Senescence Detection Kit - SPiDER-ßGal · Cellular Senescence Plate ...
#8. Senescent Cell Depletion Through Targeting BCL-Family ...
In this review, we discuss five different p16 INK4a reporter mice and various known pharmacological strategies to clear senescent cells. We also ...
#9. Cells exhibiting strong p16INK4a promoter activation in vivo ...
In prior work, activation of the p16 INK4a promoter has been used to suggest senescence in vivo. Our laboratory and others have placed reporter ...
#10. CellEvent™ Senescence Green Detection Kit - Thermo Fisher
The CellEvent Senescence Green Detection Kit consists of a fluorescent probe and optimized buffer that enable the image-based detection of senescent cells.
#11. Defined p16High Senescent Cell Types Are Indispensable for ...
The concern, howev- er, is whether the reporter construct with a part of the p16 genomic sequence fully resembles endogenous p16 gene expression ...
#12. Senescence and apoptosis: dueling or complementary cell ...
Prolonged p16 Ink4a expression results in a permanent cell cycle arrest, often with a 2N G1 DNA content. Using the FUCCI reporter system to monitor cycle stages ...
#13. p16-3MR: a novel model to study cellular ... - bioRxiv
p16-3MR mice has a trimodal reporter fused to the promoter of p16 INK4a gene that enables detection, isolation and selective elimination of ...
#14. Journalists in Aging Fellows Program - The Gerontological ...
For 11 years, GSA's Journalists in Aging Fellows Program has fueled ... when most news organizations have no resources to assign a reporter to cover aging.
#15. A Two-Photon Probe Based on Naphthalimide-Styrene ...
Cellular senescence is a state of stable cell cycle arrest that can ... detachment of labeled reporters: The example of urea detection.
#16. Joao Passos, Ph.D. - Mayo Clinic Faculty Profiles
Joao Passos, Ph.D., investigates the role of senescent cells in aging and ... tissues using super-resolution microscopy and reporter systems that allow the ...
#17. p16-3MR Reporter Mouse Model - ATS Journals
TP109. TP109 COPD AND E-CIGARETTES: PRE-CLINICAL MODELS AND MECHANISMS · p16-3MR Reporter Mouse Model: Role of Cellular Senescence in Cigarette Smoke-Induced ...
#18. Cellular Senescence: Mechanisms, Morphology, and Mouse ...
Cellular senescence is a cell cycle arrest in damaged or aged cells. ... p16-positive cells including the p16-3MR (tri-modal reporter) and ...
#19. MicroRNA‑7 modulates cellular senescence to relieve ...
Luciferase reporter assay. To determine the miR-7 target genes, PANC-1 cells cultured in 24-well plates were co-transfected with reporter ...
#20. Sensitive Detection and Monitoring of Senescence-Associated ...
Senescence -associated secretory phenotype (SASP) is characterized by ... secreted alkaline phosphatase (SEAP) has been used as a reporter to ...
#21. Cellular Senescence Promotes Skin Carcinogenesis through ...
senescence and the SASP act on endogenous tumor growth in vivo ... reporter in the p16-3MR transgene (6) and measured luminescence in.
#22. Epithelial innate immunity mediates tubular cell senescence ...
These mice had been generated by cloning the gene encoding the trimodality reporter (3MR) fusion protein, which contains functional domains of a ...
#23. Opposing p53 and mTOR/AKT promote an in vivo switch from ...
Apoptosis and senescence are the two major outcomes upon ... controls were treated with the correspondent dilution of the solvent.
#24. Cellular senescence limits translational readthrough
To measure readthrough after therapy-induced senescence, PC3 and MDA.MB.231 cells were retrovirally transduced with luciferase reporter AQP4 or UGA.
#25. A compound to counteract aging? - VUMC Reporter
A compound that increases lifespan in yeast is offering clues to pharmacological approaches that might slow the aging process and improve ...
#26. Cellular Senescence & Lung Disease - ILH Gießen
Cell senescence is pivotal in various age-associated lung diseases. ... To this end, several senescence reporter-ablator mouse models have been developed by ...
#27. Senescence β-Galactosidase Staining Kit - Cell Signaling
See how well this product performs for Reporter gene assay β-galactosidase substrates - Huh7.
#28. Upregulation of lactate-inducible snail protein suppresses ...
The qRT-PCR and dual luciferase reporter assay were performed to investigate ... on oncogene-induced senescence in human lung epithelial cells.
#29. Cellular senescence in the lung across the age spectrum
Cellular senescence results in cell cycle arrest with secretion of ... of flow cytometry with green fluorescent protein-tagged reporter genes for p21, p16, ...
#30. Trabectedin modulates the senescence-associated secretory ...
Senescent tumor cells acquire a secretory phenotype, or SASP, ... in senescent cells exposed to trabectedin, by luciferase reporter assay.
#31. Cellular senescence mediated by p16 INK4A -coupled miRNA ...
Abstract. p16 is a key regulator of cellular senescence, yet the drivers of this ... transfection using the Dual-Luciferase Reporter Assay system (Promega).
#32. Cdkn1a transcript variant 2 is a marker of aging and cellular ...
Cellular senescence is a cell fate response characterized by a permanent cell ... For example, p21 Cip1/Waf1 reporter mouse have shown increased reporter ...
#33. Mitochondrial Dysfunction Induces Senescence with a Distinct ...
Dysfunctional mitochondria cause cell senescence and a ... (F) NF-kB reporter activity in cells cultured as in (E).
#34. Senescence-Detection-Kit-SEAP-Reporter-Gene-Assay.pdf
Senescence Detection Kit (SA-ß-gal Staining). SEAP Reporter Gene Assay. Description: Senescence detection kit is a fast, convenient and.
#35. Expression of SUMO-2/3 Induced Senescence through p53
由 T Li 著作 · 2006 · 被引用 126 次 — Cellular premature senescence is a program triggered by cells ... The p53 response reporter plasmids pRGC-Luc and.
#36. Cellular Senescence Impairs Circadian Expression of Clock ...
The Per1 promoter luciferase reporter gene construct was a gift from Dr S. Yamazaki (University of Virginia). Statistical Analysis.
#37. Manipulating senescence in health and disease: emerging tools
Cellular senescence is a stress response ... in tumor suppression, tissue repair, aging, ... senescence-associated (SA)-reporters have.
#38. CSIG Inhibits PTEN Translation in Replicative Senescence
... of a PTEN 5′ UTR-luciferase reporter. Moreover, overexpression of CSIG significantly delayed the progression of replicative senescence, ...
#39. Hypoxia inhibits senescence and maintains mesenchymal ...
We found that hypoxic culture not only prevented the senescence noted in expanded ... and the schematic representation of the pGL3-E2A reporter construct.
#40. The 93rd Annual Meeting of JBS - Confit
[3S09a-05] Development of novel senescence reporter mice and the glycosylation pattern of senescent cells. ○ Nishikimi Akihiko, Mitsuo Maruyama (National ...
#41. Platform — unlocking senescence for cancer - Oncosence
Senescence Screening Platform: Cancer cells harboring a reporter gene that is activated during senescence are used for genome-scale genetic screens to find ...
#42. Senescence therapy for cancer | SENCAN Project - CORDIS
... reporter gene that is activated selectively in senescent cells, we will search for genes and compounds that induce senescence in cancer ...
#43. Senotherapeutics: emerging strategy for healthy aging and ...
Cellular senescence (CS) is one of hallmarks of aging and ... reporter (p16-3MR) mouse, in which p16 Ink4a -positive senescent cells were ...
#44. Role of senescence in paediatric high-risk brain tumours
The senescence reporter mice are available and the in-utero electroporation techniques are established in the lab. It is anticipated that Aim 1 will be ...
#45. Bavachalcone Enhances RORα Expression, Controls Bmal1 ...
This natural ingredient activated RORα1 luciferase reporter activity on drug ... Moreover, bavachalcone suppressed senescence in human endothelial cells and ...
#46. Cellular senescence: an unexpected advantage in wound ...
Cellular senescence, has a complex role in homeostasis. ... fluorescent protein (RFP) reporters and herpes simplex virus-1 thymidine kinase, ...
#47. Targets of AtWRKY6 regulation during plant senescence and ...
The strongest WRKY6 expression was observed during leaf senescence but was ... (A)WRKY6 promoter-driven GUS reporter gene activity (6p) was monitored in ...
#48. Bailey LeFever - Tampa Bay Times
Seniors/aging reporter. I cover elders and aging in the Tampa Bay area. I'm proud and grateful to be a 2020 Report for America fellow and work for the paper ...
#49. Mandatory Abuse Reporting - Pennsylvania Department of ...
All reports of abuse should be reported to the local Area Agency on Aging and licensing agencies. If the suspected abuse is sexual abuse, serious physical ...
#50. Senescence - Wikipedia
Senescence or biological aging is the gradual deterioration of functional characteristics in ... "Knock-in reporter mice demonstrate that DNA repair by non-homologous end ...
#51. The DNA damage response induces inflammation and ... - Eriba
INTRODUCTION: Cellular senescence is a pro- ... orescent protein–tagged senescence reporter ... duced senescence, whereas disruption of GATA4.
#52. DNA Damage Signaling and p53-dependent Senescence ...
Hence, β-interferon–induced senescence targets preferentially cells with ... the HDM2-luciferase reporter (p = 0.005; Figure 5C) and senescence (p = 0.014; ...
#53. About the lab. - 스트레스 반응 및 노화 연구실
Autophagy and cellular senescence are among critical as 1) they respond to. ... senescence, and the SASP, and 4) develop the stress-specific reporter system ...
#54. The senescence-accelerated mouse prone 8 as a model for ...
The senescence-accelerated mouse prone 8 (SAMP8) is a mouse model containing a ... (C) Chemiluminescence utilising luminol–peroxidase as a reporter of ROS ...
#55. UBE2E3 regulates cellular senescence and osteogenic ...
Senescence and osteogenic differentiation inhibition of bone marrow mesenchymal stem cells (BMSCs ) are supposed to play an important part ...
#56. First-generation species-selective chemical probes for ...
Human senescence-associated β-galactosidase (SA-β-gal), the most widely used biomarker of aging, is a valuable tool for assessing the extent of cell ...
#57. An aging person's walking pace may be indicator of ...
An aging person's walking pace may be indicator of Alzheimer's risk, ... Fredrick Kunkle Fredrick Kunkle is a reporter on the Metro desk.
#58. Chromosome Structures—Advances in Research and Application: ...
However, its role in cellular senescence remains unclear.” Our news journalists obtained a quote from the research from Yeungnam University, “MCAK/Kif2C ...
#59. Stem Cells—Advances in Research and Application: 2013 Edition
senescence. in. human. fibroblasts. By a News Reporter-Staff News Editor at Life Science Weekly — Research findings on Geriatrics and Gerontology are ...
#60. Annual Plant Reviews, Senescence Processes in Plants
Whether BRs also induce ethylene biosynthesis during senescence is a question that remains ... 4 showed upregulation of the reporter after BR application.
#61. Protein Metabolism and Homeostasis in Aging
... proteins in pathways leading to cellular senescence and aging. ... as shown by reporter assays.67 In contrast, over-expression of SUMO-1 appears not to ...
#62. Cellular Senescence and Tumor Suppression
In conjunction, the research cited above has established that senescence is a bona ... to confer tumor specific expression to a GFP reporter (Zindy et al.
#63. Hypothalamic Hormones—Advances in Research and Application: ...
The significant decline in GnRH-R during senescence may be due to a significant ... According to the news reporters, the research concluded: “Furthermore, ...
#64. Alzheimer's and Dementia Research News and Press Releases
Newswise: Cedars-Sinai Gifted $10M to Create Memory and Aging Program ... A reporter's PressPass is required to access this story until the embargo expires ...
#65. Study finds tuberculosis can induce premature cellular ageing
The findings of the study were published in the journal 'Aging'. ... ThePrint has the finest young reporters, columnists and editors working ...
#66. CZC-94 - Potential Game Changer for Cumin Cultivation in ...
... but, CZC-94 escapes the terminal heat stress encountered during the maturity causes forced senescence. Over the Years, the Western Disturbances causing ...
#67. Between Wike's temper and Anambra's valedictory slap, By ...
... of the state capital, the bulk of whom were senescent, frail and grey-haired women. ... Festus Adedayo is an Ibadan-based journalist.
#68. Aging and Adult Services - NC DHHS
The Division of Aging and Adult Services is responsible for planning, administering, coordinating and evaluating activities and programs for older adults.
#69. Got half a mind to ramble | Power Line
... week have made for a dangerous spectacle of debility and senescence. ... The German reporter Smith quoted is Der Spiegel Brussels bureau ...
#70. Got half a mind to ramble – Aukus Digital Edition ® - UEL ...
... week have made for a dangerous spectacle of debility and senescence. ... The German reporter Smith quoted is Der Spiegel Brussels bureau ...
#71. NutraCast: Improving Lifespan Via 'zombie Cell' Elimination ...
Senescent cells accumulate with age and are associated with many disease ... Researchers believe that these cells have a lot to do with advanced aging and ...
#72. Akiko Takahashi Project for Cellular Senescence
On the other hand, it has been proven that senescent cells are accumulating during aging process throughout living body and secrete many inflammatory protei ns ...
#73. How to Identify Senescence in Cells and Tissue | CST Tech Tips
#74. CellAge: The Cell Senescence Gene Database
Human cells become senescent from progressive shortening of telomeres as cells divide, stress or oncogenes. Primarily an anti-tumour mechanism, senescent cells ...
#75. Issues in Genetic Diseases and Disorders: 2013 Edition
senescence. in. normal. and. tumor. human. melanocytic. cells. By a News Reporter-Staff News Editor at Health & Medicine Week — Investigators publish new ...
#76. The Plant Disease Reporter - 第 57 卷 - 第 929 頁 - Google 圖書結果
If these North Dakota varieties were set apart , there seemed to be another general but less obvious correlation between yield and senescence of vines in ...
#77. How to Identify Senesence in Cells and Tissue
#78. Overview of Cell Senescence - SENS Research Foundation
Researchers have found that senescent cells accumulate in our body as we age. Deciphering the purpose, causes, and consequences of cellular senescence will ...
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