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#1. Dactinomycin
Mechanism Edit ... In cell biology, actinomycin D is shown to have the ability to inhibit transcription. Actinomycin D does this by binding DNA at the ...
#2. Actinomycin - an overview | ScienceDirect Topics
Mechanism of action ... The most important biochemical effects of actinomycin D are binding to single- and double-stranded DNA and subsequent inhibition of RNA ...
#3. Actinomycin D - an overview
Act D binds to DNA so as to inhibit elongation executed by RNA polymerase. COR (3′-deoxyadenosine), which is converted to the triphosphate analogue in the cell, ...
#4. Dactinomycin: Uses, Interactions, Mechanism of Action
Dactinomycin is believed to produce its cytotoxic effects by binding DNA and inhibiting RNA synthesis. Mechanism of action ... actinomycin D, cyclophosphamide, ...
#5. Novel Molecular Mechanism for Actinomycin D Activity as an ...
Actinomycin D is an anticancer antibiotic best known for inhibiting transcription by binding double-stranded DNA. Tight, sequence selective ...
#6. Actinomycin D enhances killing of cancer cells by ...
We show here that actinomycin D activates the extrinsic pathway of apoptosis and acts synergistically with RG7787 to kill a variety of cancer ...
#7. The mechanism by which actinomycin D inhibits protein ...
Using enucleated lymphocytes, we have shown that AMD has no effect on protein synthesis in the absence of the cell nucleus and conclude that AMD interferes with ...
#8. The molecular mechanism of actinomycin D in preventing ...
The pathological mechanism of restenosis is primarily attributed to excessive proliferation of vascular smooth muscle cells (SMC). Actinomycin D has been ...
#9. Dactinomycin - Mechanism, Indication, Contraindications, ...
Dactinomycin. Synonym : Actinomycin-D. Mechanism : Dactinomycin is one of the actinomycin, a group of antibiotics produced by various species of Streptomyces.
#10. Actinomycin D#15021
Actinomycin D inhibits mRNA transcription in mammalian cells. Actinomycin D intercalates DNA and stabilizes topoisomerase I-DNA covalent complexes, blocking RNA ...
#11. "Mechanisms of Apoptosis Induced by Actinomycin D in ...
Upper aerodigestive tract cancers including cancers of the oral cavity, pharynx, larynx, esophagus, and lungs are the most prevalent cancers and leading ...
#12. The molecular mechanism of actinomycin D in preventing ...
The pathological mechanism of restenosis is primarily attributed to excessive proliferation of vascular smooth muscle cells (SMC). Actinomycin D has been r.
#13. mechanism of actinomycin D-mediated inhibition of HIV-1 ...
Actinomycin D (ActD) is a widely used antibiotic and anti-cancer drug that specifically inhibits DNA-dependent DNA and RNA synthesis (4–6). The drug interacts ...
#14. Actinomycin D
Mechanism of Action: Actinomycin is a cyclic polypeptide-containing antibiotic that binds to DNA and inhibits RNA polymerase activity. Because Actinomycin ...
#15. Molecular mechanism(s) of actinomycin-D induced ...
Molecular mechanism(s) of actinomycin-D induced sensitization of pancreatic cancer cells to CD95 mediated apoptosis. Authors: Alexey L ...
#16. Actinomycin D- mechanism, solubility, apoptosis
Actinomycin D binds the DNA at the transcription initiation complex and prevents any elongation by RNA polymerase. It can interfere with DNA replication as it ...
#17. ORIGINAL RESEARCH article
The mechanism is that Act D interacts with guanine and cytosine base pairs in DNA through the phenoxazone ring and forms hydrogen binds that ...
#18. Actinomycin D | RNA polymerase inhibitor | Cas# 50-76-0
Actinomycin D is a significant polypeptide antibiotic isolated from soil bacteria, Streptomyces. It inhibits DNA repair with IC50 of 0.42 μM and rests the cell ...
#19. Investigations of the Mechanism of Cell Killing Induced ...
Abstract. At high concentration, actinomycin D kills the protozon Chlamydomonas reinhardi with exponential kinetics. The rate of killing is ...
#20. [Actinomycin D and its mechanisms of action].
... been proposed that could indicate one particular mechanism of action as responsible for the biological activity of actinomycin D.
#21. Actinomycin D / Dactinomycin | Drug Guide
Mechanism of Action. Binds to DNA, resulting in prevention of RNA transcription and protein synthesis. Pharmacology. Bone marrow-sparing, therefore often ...
#22. The molecular mechanism of actinomycin D in preventing ...
The pathological mechanism of restenosis is primarily attributed to excessive proliferation of vascular smooth muscle cells (SMC). Actinomycin D has been ...
#23. Actinomycin D Down-regulates SOX2 Expression and ...
In light of this, going forward we decided to look at the mechanism involved in the actinomycin D- mediated cell death in tumoroids. Actinomycin D depletes ...
#24. Actinomycin D Arrests Cell Cycle of Hepatocellular ... - MDPI
Thus, the drug has been useful in the treatment of rare and highly aggressive cancers such as HB [10,11], embryonal sarcoma of the liver, Wilms tumor, ...
#25. Actinomycin D enhances killing of cancer cells by ...
A potential mechanism linking apoptosis to transcription inhibition is proposed a more recent study: DACT inhibits, among others, cyclins A, D1, E mRNA ...
#26. Actinomycin d
Methylated actinomycin D, a novel actinomycin D analog ... The role of P53 reactivation by LDActD in the synergism and its mechanism were.
#27. Actinomycin D induces apoptosis and inhibits growth of ...
Actinomycin D (actD) is a potent inducer of apoptosis in a variety of cells in vitro and in vivo. It binds to DNA and inhibits RNA and protein ...
#28. Effect of low doses of actinomycin D on neuroblastoma cell lines
Actinomycin D has been used clinically for over 50 years for the treatment of children and adult cancer. As part of a multimodal therapy, ...
#29. Actinomycin
Actinomycin -D is primarily used as an investigative tool in cell biology to inhibit transcription. It does this by binding DNA at the ...
#30. Actinomycin D Supplier | CAS 50-76-0
Actinomycin D is an anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis. Technical Data for Actinomycin D. M. Wt, 1255.43.
#31. 12.3.2: Anti-Cancer Drugs II
Dactinomycin (Actinomycin D). Mitotic Disrupters. Taxol. Mechanism of Intercalating Agents; Contributors. Hydroxyurea. Hydroxyurea blocks an ...
#32. MetaCyc actinomycin D biosynthesis
Actinomycin D was the first antibiotic shown to have anti-cancer activity ... mechanism for the formation of the phenoxazinone chromophore of ...
#33. Study on the mechanism of the interaction between anticancer ...
Study on the mechanism of the interaction between anticancer drug actinomycin D and calf thymus DNA by fluorescence method. Li Laisheng;Huang Weidong;Wang ...
#34. ACTINOMYCIN D Synthesis, SAR, MCQ,Structure ...
Structural Activity Relationship · Lactone rings in the dactinomycin stabilizes the peptide chains in such a conformation which enables the ...
#35. Production of actinomycin-D by the mutant of a new isolate ...
RNA polymerase mutation activates the production of a dormant antibiotic 3,3'-neotrehalosadiamine via an autoinduction mechanism in Bacillus subtilis J. Biol.
#36. Actinomycin D for fibrosis management in ophthalmic ...
Actinomycin D. However, these findings could only be confirmed on α-SMA ... Actinomycin D and its mechanism of action. Postepy Hig Med Dosw 2005; 59:290 ...
#37. Actinomycin D-Activated RNase L Promotes H2A.X/H2B ...
Background: Chemotherapy is an essential component for comprehensive cancer treatment, while drug resistance usually fails therapy. DNA repair mechanism of ...
#38. Dactinomycin (actinomycin D) | Cancer information
Dactinomycin is a type of chemotherapy drug. It is also known as actinomycin D. You pronounce dactinomycin as dac-tin-oh-mye-sin. It is a treatment for a number ...
#39. Actinomycin D inhibits cell proliferations and promotes ...
The present study have revealed a novel mechanism by which ActD inhibits osteosarcoma cell proliferations and induces apoptosis, and will ...
#40. Actinomycin D Induces High-Level Resistance to Thymidine ...
Thus, ActD blocks reverse transcription by a mechanism that is quite different from that of nucleoside RT inhibitors. It has been suggested that ...
#41. MUTAGENICITY OF ACTINOMYCIN D IN MAMMALIAN ...
2C mouse lymphoma cells. The majority of the mutants were small colonies, indicating that actinomycin D acts primarily by a clastogenic mechanism. The authors ...
#42. investigations of the mechanism
Actinomycin D (i\MD) is a widely used inhibitor of DNA-dependent. RNA synthesis. The drug acts by intercalating between guanosine- cytosine base pairs of DNA ...
#43. Actinomycin D: Effect on the Immune Response
Actinomycin D injected simultaneously with sheep erythrocytes in female ... Schwartz, S. R., Mechanism of Cell Tissue Damage Produced by Immune Reactions (1961).
#44. Transcription inhibition by Actinomycin D as a mechanism ...
Transcription inhibition by Actinomycin D as a mechanism-based approach to treatment of Bcr-Abl-positive chronic myelogenous leukemia. Rong ...
#45. MetaCyc actinomycin D biosynthesis
Actinomycin D was the first antibiotic shown to have anti-cancer activity ... mechanism for the formation of the phenoxazinone chromophore of ...
#46. Actinomycin D
It binds to DNA duplexes, thereby interfering with the action of enzymes engaged in replication and transcription. Actinomycin D is one of the old chemotherapy ...
#47. Actinomycin D | CAS:50-76-0 | RNA polymerase inhibitor
The molecular mechanism of actinomycin D in preventing neointimal formation in rat carotid arteries after balloon injury. J Biomed Sci. 2005;12(3):503-12. [3].
#48. The Effect of Actinomycin D on Childhood Neoplasms
3. Foley, G. E.: Preliminary Observations on the Mechanism of Action of Actinomycin D in Microbiological Systems , Antibiotics Ann. 1955-1956 , New York, ...
#49. Stimulation of Superoxide Formation by Actinomycin D and ...
The mechanism of action of actinomycin D (AMD) is related to its interactions with DNA and inhibition of RNA synthesis. Recently, it has ...
#50. Spermine Attenuates the Action of the DNA Intercalator ...
Spermine Attenuates the Action of the DNA Intercalator, Actinomycin D, on DNA Binding and the Inhibition of Transcription and DNA Replication. Sheng-Yu Wang, ...
#51. Antifungal effects of actinomycin D on Verticillium dahliae ...
The antifungal activity of actinomycin D damaged the fungal plasma membrane of V. dahliae via a membrane-splitting mechanism, which provided new ...
#52. Paradoxical Effect of Actinomycin D
Regulation of protein synthesis in chick oviduct. III. Mechanism of ovalbumin "superinduction" by actinomycin D. J. Biol. Chem. 248: 1502-1512.
#53. DRUG NAME: Dactinomycin
Dactinomycin. DRUG NAME: Dactinomycin. SYNONYM(S)1: actinomycin D, actinomycin C1. COMMON TRADE NAME(S): COSMEGEN®. CLASSIFICATION: antitumour ...
#54. Inhibition by Actinomycin D of Oxidation-dependent ...
The oxidative and glycolytic energy-yielding systems in ascites tumor cells can be strikingly independent of each other, allowing either of these mechanisms to ...
#55. Effects of inhibiting transcription and protein synthesis on ...
These results suggest that the mechanism by which actinomycin D increases leptin secretion and expression may be mediated by glucose metabolism. However ...
#56. 探討精胺對放線菌素D作用於DNA之影響
放線菌素D(actinomycin D,ACTD)是一種與DNA結合的抗癌藥物,其與DNA結合機制是嵌入(intercalation)DNA的鹼基與鹼基之間,主要嵌入位置為DNA上的GC序列,以抑制DNA的 ...
#57. Molecule of the Month: Actinomycin - PDB-101
Actinomycin is the first natural antibiotic discovered that has anti-cancer activity. It was discovered in the bacterium Streptomyces antibioticus in 1940.
#58. Change of Basis for the Listing of Actinomycin D as ... - OEHHA
Actinomycin D was originally added to the Proposition 65 list as causing cancer via the Labor Code listing mechanism[2]. OEHHA changes the basis ...
#59. Binding of Actinomycin D to Single-Stranded DNA ...
If the drug induced fold-back to form a G • C basepair is indeed the mechanism for ACTD binding to d(TGTCTTTTG), its binding may be affected by base additions ...
#60. US4680382A - Analogues of actinomycin D
Furthermore, the proximal mechanism of biochemical action of AMD, which is evident from the inhibition of RNA synthesis, may not be the principal mechanism of ...
#61. Low-dose Actinomycin-D treatment re-establishes the ...
... Actinomycin-D due to the molecular mechanism of action. The lack of effects in SJ-BT57 cells could be attributed to the much higher p53 ...
#62. Actinomycin D (Dactinomycin) Datasheet
Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an ...
#63. Polypeptide antibiotic actinomycin D induces Mcl-1 ...
... explored the effects and molecular mechanism of Act D-induced Mcl-1 downregulation. Main methods Human adenocarcinoma A549 cells we.
#64. Antitumor antibiotics
D) Strong antiemetics should be ordered with actinomycin D. Page 10. Last Updated on January 15, 2007. BLEOMYCIN. (BLENOXANE®). I. MECHANISM OF ACTION. A cell ...
#65. Some Insights into the Cellular Responses Against ...
poisoning from the mechanism of action from actinomycin D. The opposite findings on the transcription related genes reassured our findings ...
#66. Mechanism of intestinal radiosensitization by actinomycin D
Hagemann, Ph.D. and Joseph P. Concannon, M.D.. Celluar and Radiation Biology Laboratories, Clinical Radiation Therapy Research Centre, Department of. Radiology ...
#67. ON THE DIFFERENTIAL CYTOTOXICITY OF ...
Actinomycin D (AMD) at concentrations that inhibit cellular RNA synthesis by 85% or more causes an acute phase of lethal cell degeneration ...
#68. Neutral metalloaminopeptidases APN and MetAP2 as ...
Actinomycin D is a long-known drug that was developed as an anticancer agent years before apoptosis and other cell death mechanisms and cancer progression were ...
#69. Dactinomycin dosing, indications, interactions, adverse ...
Mechanism of Action. Actinomycin antibiotic; intercalates into DNA base pairs preventing RNA, DNA, and protein synthesis ; Distribution. Protein bound: Low.
#70. What is the mechanism of dactinomycin?
Oncology:Pharmacology: Dactinomycin is a non cell cycle speficic antitumor antibiotic that inhibits transcription by binding to DNA and ...
#71. Anti-tumor antibiotics: Video, Anatomy & Definition
Common antitumor antibiotics are mitomycin, anthracyclines which include drugs like doxorubicin, actinomycin D, and bleomycin. Sources.
#72. Metabolic labelling of RNA uncovers the contribution ...
We confirmed this result by estimation of individual mRNA levels over time upon inhibition of transcription with actinomycin D under normoxia or ...
#73. Targeting the RNA Polymerase I Transcription for Cancer ...
... mechanism for actinomycin D activity as an oncogenic promoter. G-quadruplex binder. Biochemistry 2009, 48, 7392–7398. [CrossRef]. 68. Rhodes, D ...
#74. Nucleolar Stress: hallmarks, sensing mechanism and ...
This phenomenon was initially observed when ribosome biogenesis was blocked by Actinomycin D (Act.D), a Pol I inhibitor [14], and soon ...
#75. Cosmegen® for Injection - Accessdata.fda.gov
(dactinomycin for injection). (Actinomycin D). Rx only. WARNING. COSMEGEN® (dactinomycin for injection) should be administered only under the supervision of a ...
#76. HDAC11 inhibition triggers bimodal thermogenic pathways ...
Pretreatment with actinomycin D had no effect on UCP1 protein induction following 5 minutes of FT895 treatment, but substantially reduced UCP1 ...
#77. Transcription II- Post transcriptional modifications and ...
Mechanism of action of Actinomycin D • Actinomycin D- Intercalates with DNA strands • Actinomycins inhibit both DNA synthesis and RNA ...
#78. Molecular and Cellular Mechanisms in Disease: 1: ...
... actinomycin D, yet actinomycin D only partially abolishes gluconeogenesis. Consequently, factors other than de novo synthesis of gluconeogenic enzymes seem ...
#79. Schering Workshop on Steroid Hormone 'Receptors', Berlin, ...
... actinomycin D is added at this stage in the action of the steroid, enzyme ... mechanism for the regulation of gene expression in eukaryotic cells. Work is ...
#80. Jaundice - 第 91 頁 - Google 圖書結果
... mechanism of induction of heme oxygenase involves the Synthesis of SOme new enzyme moiety or binding ... Actinomycin- D METHEMALBUMIN O INDUCTION MECHANISMS 9]
#81. Gene Regulation by Steroid Hormones IV - 第 183 頁 - Google 圖書結果
... actinomycin D, an inhibitor of RNA synthesis, increases chromatin-bound and ... mechanism, 3'-dA may interfere with recycling of androgen receptors and ...
#82. Journal of the National Cancer Institute: JNCI.
... mechanism of acti- nomycin D action . Nature 1976 ; 263 : 347-349 . # --聞 Thomas M. Kloppel 4.5 and D. James ... Actinomycin D and In Vitro Transformation 1399.
#83. Drug Interactions; an Annotated Bibliography with Selected ...
... actinomycin D on the growth , DNA , RNA and protein contents of Ehrlich ... MECHANISM OF INTERACTION ( S ) Primabolin increases euchromatic effect of ...
#84. The Antimicrobial Drugs - 第 361 頁 - Google 圖書結果
... Mechanism of blockage of amphotericin B channels in a lipid bilayer. Biochim ... D. Schwartz, A VertutCroquin, D. Schlesinger, G. Kobayashi, and G. Medoff ...
#85. Research Awards Index - 第 1 卷,第 1 篇 - 第 4 頁 - Google 圖書結果
... ACTINOMYCIN SEE ANTIBIOTICS , ACTINOMYCIN C SEE ANTIBIOTICS , ACTINOMYCIN D ... Mechanism of control of fatty acid synthesis ( rats , chickens ) ROICA - 11949-09 ...
#86. Subject Index of Current Research Grants and Contracts ...
... ACTINOMYCIN PO1GM - 14552-09 0019 Normal and abnormal cell growth multidiscipline study Mechanism ... D RO1GM - 13939-09 coli ) Purine - pyrimidine crystalline ...
#87. sketchy pharm - E-Riset
It really helps with mechanism of action as well. Nicotinic receptors found ... Sketchy Pharm: Bleomycin, Doxorubicin, Daunorubicin, Actinomycin D. Prepare ...
#88. hicmos.it non antineoplastic hazardous drugs
The important drugs in this group include actinomycin D (dactinomycin), doxorubicin, mitoxantrone, and bleomycin. ... mechanism for updating their list as new ...
#89. alcar half life
Acetylcysteine: Dosage, Mechanism/Onset of Action, Half. It's a mode that ... After treating with a transcription inhibitor actinomycin D, the half-life ...
actinomycin d mechanism 在 What is the mechanism of dactinomycin? 的推薦與評價
Oncology:Pharmacology: Dactinomycin is a non cell cycle speficic antitumor antibiotic that inhibits transcription by binding to DNA and ... ... <看更多>