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#1. Structure and mechanism of ABC transporters - NCBI
In the case of ABC transporters, conformational switching of the membrane domain for providing alternating access is driven by the binding of ...
#2. Mechanism of ABC transporters: A molecular dynamics ...
ATP-binding cassette (ABC) transporters utilize the energy of ATP hydrolysis to translocate a wide variety of solutes across cellular membranes. These molecular ...
#3. The mechanism of ABC transporters: general lessons from ...
Many bacterial ABC transporters function as importers, and binding of an extra-cytoplasmic substrate-binding protein to the outward-facing ...
#4. Review Mechanism of Action of ABC Importers: Conservation ...
由 O Lewinson 著作 · 2017 · 被引用 76 次 — The NBDs supply the energy via ATP binding and hydrolysis, while the TMDs form the transmembrane permeation pathway. An ABC transporter may ...
#5. (PDF) Structure and mechanism of ABC transporters
The removal of chemicals from STBs is accomplished by ABC transporters (Wilkens, 2015) (Figure 2). Upon substrate binding, ABC transporters generate energy from ...
#6. The impact of ATP-binding cassette transporters on metabolic ...
ABC transporters can be classified into importers and exporters [7]. The transport mechanism of ABC transporter is controlled by alternating the ...
#7. The Role of Eukaryotic and Prokaryotic ABC Transporter ...
由 R El-Awady 著作 · 2017 · 被引用 105 次 — Many ABC transporters have important effects on pathogen–host interactions, either by improving bacterial growth in nutrient-restricted ...
#8. ABC transporters, mechanisms and biology: an overview
... of the mechanism of action of ABC transporters at the atomic level, ...
#9. Molecular Mechanism of ATP Hydrolysis in an ABC Transporter
ABC transporters can be understood as ATP-powered molecular machines. Their working cycle is based on the conversion of the chemical energy ...
#10. Structure and mechanism of ATP-binding cassette transporters
ATP-binding cassette (ABC) transporters are a large superfamily of membrane proteins with diverse functions (Holland et al. 2003).
#11. Structure and Function of ABC Transporters | Physiology
Mechanism of Action of an MDR Exporter. Extensive biochemical studies of the ATP catalytic cycle linked to pharmacological studies of drug affinity make P- ...
#12. Inhibitors of ABC Transporters and Biophysical Methods to ...
tion of the structure of the ABC transporters is ... The ABC transporter activity encompasses sev- ... a mechanism of modulator activity through in-.
#13. Structure and function of ABC transporters: the ATP switch ...
ATP-binding cassette (ABC) transporters are ubiquitous integral membrane ... Mechanism of action of human P-glycoprotein ATPase activity.
#14. Mechanism of Coupling of Transport to Hydrolysis in Bacterial ...
A typical ABC transporter has four domains or subunits, ... provided new insight into the mechanism of action of this family of proteins.
#15. Structure and mechanism of ABC transporters Lutz Schmitt ...
ATP-binding cassette (ABC) transporters are central to many ... structures of full-length ABC transporters and isolated ABC ... and mechanism of action.
#16. The ABC Transporters of Human Physiology and Disease
General Introduction, Structure and Likely Mechanism of Action of ABC Transport Proteins (Kenneth J Linton, Joseph K Zolnerciks and Lutz Schmitt) ...
#17. Regulation of ABC Transporters by Kinases and Protein ...
It is clear that phosphorylation is an attractive mechanism to control ABC transporter activity, and may contribute to drug-drug interactions or ...
#18. Research Progress on the Role of ABC Transporters in the ...
ABC transporters can perform the funcions of a drug efflux pump, ... a different action mechanism, and symptoms were controlled in only 10% of the patients ...
#19. The Structure and Mechanism of Drug Transporters - Springer ...
Drug transporters are integral membrane proteins that play a critical role ... dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on ...
#20. The role of ABC transporters in drug resistance, metabolism ...
Many of the ABC transporters function as active transporters, they mediate the transport of substrates against a concentration gradient. This transport activity ...
#21. ABC transporters: one, two or four extracytoplasmic substrate ...
Two families of ATP-binding cassette (ABC) transporters in which one or two ... the ligand to the cytoplasm via the translocation pathway; in other words, ...
#22. Mechanisms of multidrug transporters
The mode of action of these MDR transporters and their apparent lack of substrate ... Multidrug resistance, Drug transport, ABC transporters, P-glycoprotein.
#23. ABC Transporters - YouTube
#24. Structural and Mechanistic Principles of ABC Transporters
ATP-binding cassette (ABC) transporters constitute one of the largest and most ... The Hippo pathway activity controls the dynamic localization of YAP/TAZ ...
#25. Allosteric Coupling in an Asymmetric ABC Transporter
and the molecular mechanisms of transport remain unknown. ... ATPase activity of ABC transporters, in order to identify a substrate, we.
#26. Investigating the mechanism of the Escherichia coli ATP ...
19 (Interestingly, integral membrane proteins related to ABC transporters translate the physical presence of an insect to an action potential ...
#27. Structure of MlaFB uncovers novel mechanisms of ABC ... - eLife
However, a small but growing number of regulatory proteins have been shown to stimulate or inhibit ABC transporter activity, such as MetNI ( ...
#28. Tuning the Drug Efflux Activity of an ABC Transporter in vivo ...
Our approach could be of biopharmaceutical importance and might facilitate studies on molecular mechanisms of ABC transporters.
#29. Regulation and Mechanisms of ATP-Binding Cassette ...
To evaluate the effect of apoA-I on ABCA1 as a potential mechanism for its ... Given the high specificity of lipid substrates for other ABC transporters and ...
#30. The Allosteric Regulatory Mechanism of the Escherichia coli ...
This mechanism of regulation at the transporter activity level could be applicable to not only ABC transporters but other types of membrane ...
#31. ABC transporters and multidrug resistance in Aspergillus ...
Bacterial ABC transporters involved in drug resistance ... possess ABC transporters that function in protection against the toxic action of such.
#32. ABC multidrug transporters: structure ... - Future Medicine
However, this class of proteins sheds little light on the structure or possible mechanism of action of mammalian ABC drug-efflux pumps. Three ...
#33. Structural insights into the mechanism of bacterial ABC ...
Bacteria utilise ATP-binding cassette (ABC) transporters to import nutrients and ... conformations to provide further insights into its mechanism of action.
#34. Special Issue : ABC Transporters in Human Diseases - MDPI
Structural insights into the molecular mechanisms of ABC-related diseases and the interaction of drug candidates with ABC transporters; Perspectives for ...
#35. KEGG PATHWAY: map02010
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes.
#36. Structural diversity of ABC transporters - Rockefeller University ...
Many excellent reviews on ABC transporters have been published over the past few years and cover the history, structure, mechanism, physiology, ...
#37. Dissecting the molecular mechanism of an antibiotic efflux pump
An increasing number of bacterial ABC transporters, which utilize the energy of ATP hydrolysis to expel drugs, have been implicated in multidrug resistance ...
#38. Human ABC transporter ABCG2/BCRP expression in ...
Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study. J Mol ...
#39. Brasil - ABC transporters in Mycoplasma hyopneumoniae and ...
ABC transporters represent one of the largest superfamilies of active membrane transport proteins (MTPs) with a highly conserved ATPase domain that binds ...
#40. ABC Transporters - Creative Diagnostics
An overview of the ABC transporters, involving introduction, family and function. ... and the action of these transporters results in a decreased drug ...
#41. Mechanisms governing the function of an ABC transporter
ABC transporters are membrane proteins that contain an ATP-binding cassette (ABC) as a common structural element and are involved in active ...
#42. ABC transporters - ITQB
Molecular modeling of ABC transporters: from ATP hydrolysis to substrate ... ABC members, many fundamental questions about the transport mechanism of these ...
#43. ABC transporters in multidrug resistance and ...
A common mechanism is the overexpression of ATP-binding cassette (ABC) efflux transporters in cancer cells such as P-glycoprotein (P-gp/ABCB1), ...
#44. ABC Transporters: An Overlooked Mechanism of Drug Failure ...
Given its mechanism of action and use as a chemotherapeutic agent, it is not surprising that exposing the lungs to bleomycin may induce cellular defense ...
#45. ABC transporter-like, ATP-binding domain (IPR003439)
ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems.
#46. Full article: Mechanism of the ABC transporter ATPase domains
The prevailing paradigm for the ABC transport mechanism is the Switch Model ... not require ATP hydrolysis, because the E166A mutant had no ATPase activity.
#47. ABC Transporters: Molecular Machineries in Cellular ...
Significant insights into the activity of ABC transporters have been gained from functional ... we are able to decipher details of the transport mechanism.
#48. ATP-Binding Cassette (ABC) Transporters and Their Role in ...
and schematic mechanism are shown in Figure 1: ABC transport- ... Inflammation is known to suppress the expression and activity.
#49. ABC Transporters and Cancer Drug Resistance - Sigma-Aldrich
The transport activity of ABC proteins has an important effect on the efficacy of pharmaceuticals by modulating the absorption, distribution, and excretion ...
#50. A transport machine -- ATP-binding cassette - Cusabio
The efflux of cytotoxic drugs mediated by ATP-binding cassette transporters is the "classical MDR" pathway. ABC transporters pump drugs out of cells and reduce ...
#51. ABC multidrug transporters: structure, function and role in ...
Single nucleotide polymorphisms in ABC drug-efflux ... exploring the transport activity of the ABC pro- ... The mechanism of action of modulators.
#52. Mouse ATP-Binding Cassette (ABC) Transporters Conferring ...
The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The re.
#53. Abc seminar - SlideShare
ABC OR ATP BINDING CASSETTE TRANSPORTER BY JASKAMALGILL M-PHARM (PHARMACOLOGY) 2nd semester.
#54. ABC Transporters - AK Lectures
Another type of ATP-driven membrane pump is the ATP-binding cassette transporter or simply ABC transporter. The discovery of these pumps came from studies ...
#55. ABC Transporters – The Locher Lab | ETH Zurich
ATP-binding cassette (ABC) transporters are found in all domains of life, catalyze a wide range of transport reactions, and have important physiological or ...
#56. ABC Transporters Video | LabTube
#57. Genome-wide identification of ABCC gene family and ... - X-MOL
ABC (ATP-binding cassette) transporters are a class of superfamily ... mechanism governing colored cotton fiber pigmentation formation.
#58. ABC transporters - Defending the Christian Worldview ...
ABC transporters are transmembrane proteins that utilize the energy of adenosine triphosphate (ATP) hydrolysis to carry out certain biological ...
#59. Structure of MlaFB uncovers novel mechanisms of ABC ...
This work leads to a new model for how the activity of an important bacterial lipid transporter may be regulated by small binding proteins, and ...
#60. ABC Transporter Architecture and Mechanism
Ribbon diagram of the BtuCD protein structure. The transporter is assembled from two membrane-spanning BtuC subunits (red and yellow) and two ABC cassettes BtuD ...
#61. Receptors and Cellular Transport - Plant & Soil Sciences ...
Mechanism of Action ... the binding process by describing the receptor as well as the various protein carriers that help transport auxin from cell to cell.
#62. The E. coli BtuCD Structure: A Framework for ABC Transporter ...
The ABC transporters are ubiquitous membrane proteins that couple adenosine ... Such a mechanism would be analogous to the action of a toggle joint, ...
#63. 'This Week' Transcript 3-13-22: John Kirby & Andriy Moskalenko
ANNOUNCER: From ABC News, this is a special edition of "This Week" live from ... saying action must be taken to stop this, close the sky.
#64. Mathematical model created by Queensland researcher set to ...
"What we think is the mechanism that we've described is dominant for vaccine ... "By deducing links between the activity of antibodies, ...
#65. 4.3C: ABC Transporters - Biology LibreTexts
ABC transporters are transmembrane proteins that utilize the energy of adenosine triphosphate (ATP) hydrolysis to carry out certain biological ...
#66. Project Evaluation Improvement of health care and protection ...
Activity 1.2 – Knowledge of good practice in physical and functional ... Availability, Has the project put in place mechanisms to inform ...
#67. Impact of charge patches on tumor disposition and ...
The in vitro model was able to differentiate the transport propensity of ... In summary, our results show the differential effects of charge ...
#68. First principles phonon calculations in materials science. B 51 ...
We develop a computational framework, based on the Boltzmann transport equation (BTE), ... Effects of electron-phonon and -magnon scattering on the finite ...
#69. stray animals - Press Information Bureau
20 小時前 — Effect of Major Port Authorities Act, 2021 ... need to evolve the mechanism to control stray animals in order to protect the citizens.
#70. re - IDEAVIVA
Filmmaker Assets: VFX downloads, Sound Effects, Color Grading LUTS, ... ingress The terminal block cover features a screw dropout prevention mechanism.
#71. ATP-binding cassette transporter family - IUPHAR/BPS Guide ...
Eukaryotic ABC transporters convey substrates from the cytoplasm, either out of the cell or into intracellular organelles. Their role in the efflux of exogenous ...
#72. ABC transporter disorders - Reactome Pathway Database
Click the image above or here to open this pathway in the Pathway Browser. The ATP-binding cassette (ABC) transporters form a large family of transmembrane ...
#73. crossm - CORE
由 T Weil 著作 · 2017 · 被引用 17 次 — conazole, but the underlying molecular mechanism is not understood. ... and CDR2 genes, which encode the ABC transporters (21) (CDR1, ...
#74. ABC Transporters and Multidrug Resistance
DNA sequencing technologies has enabled studies of the effects of genetic variation on ABC transporter expression and function.
#75. ABC Transporters: Biochemical, Cellular, and Molecular Aspects
pore to form the Trk K + channel.58 Whether Pgp and these other ABC transporters modulate channel activity by related mechanisms remains to be determined .
#76. Plant ABC Transporters - 第 86 頁 - Google 圖書結果
Taken together, the available data suggest that CTS is a transporter with ... although a minor alternative pathway for some compounds, such as OPDA, ...
#77. Antimicrobial Resistance in Agriculture: Perspective, Policy ...
hormone-like activity to stimulate the growth and function of mycotic cells; ... Of several classes of ABC transporters, transporters of pleiotropic drug ...
#78. Engineering - 第 69 卷 - 第 131 頁 - Google 圖書結果
This , of course , is the A B C of the matter power , which could be used ... Of course inventions intelligence . mechanism in the absorption of recoil ...
#79. English Mechanic and World of Science
—L . L. tramway and rolling stock for the transport of agricultural and other produce . [ 10147 . ) ... A. B. C. - A Poor Work- 1616 J. Bottomley and w .
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