"Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks". Chinese Journal of Cancer. 31 (8): ... ... <看更多>
「sapacitabine mechanism of action」的推薦目錄：
sapacitabine mechanism of action 在 Sapacitabine - an overview | ScienceDirect Topics 的相關結果
Sapacitabine is an oral cytarabine analog whose cyano structure causes irreparable single-strand DNA breaks. It is active in AML and patients with MDS, ... ... <看更多>
sapacitabine mechanism of action 在 5.52 The DNA-Strand-Breaking Nucleoside Analog ... 的相關結果
Sapacitabine is an orally bioavailable prodrug of the nucleoside analog CNDAC ... which has a unique mechanism of action, inducing single strand breaks ... ... <看更多>
sapacitabine mechanism of action 在 Sapacitabine - Daiichi Sankyo Company - AdisInsight - Springer 的相關結果
Sapacitabine is an orally available, small-molecule nucleoside analogue of ... Pyrimidines; Small molecules; Mechanism of Action Antimetabolites; ... ... <看更多>
sapacitabine mechanism of action 在 Sapacitabine, the prodrug of CNDAC, is a nucleoside ... 的相關結果
CNDAC has a unique mechanism of action: after incorporation into DNA, it induces single-strand breaks (SSBs) that are converted into double-strand breaks ... ... <看更多>
sapacitabine mechanism of action 在 Antiproliferative effects of sapacitabine (CYC682), a novel 2 的相關結果
Cytotoxics evaluated in this study were selected based on their mechanisms of action, including nucleoside analogues for evaluation of cross- ... ... <看更多>
sapacitabine mechanism of action 在 Sapacitabine for cancer - Taylor & Francis Online 的相關結果
The novel action mechanism of sapacitabine is discussed, with a view to validate it as a chemotherapeutic drug targeting malignancies with ... ... <看更多>
sapacitabine mechanism of action 在 Development of Sapacitabine Therapy in Leukemias - Grantome 的相關結果
Effective therapies for acute leukemias have been developed incrementally, advanced by the developmentof agents with different mechanisms of action. ... <看更多>
sapacitabine mechanism of action 在 Phase I Clinical and Pharmacokinetic Study of Oral ... 的相關結果
Purpose Sapacitabine is an oral deoxycytidine nucleoside analog with a unique mechanism of action that is different from cytarabine. ... <看更多>
sapacitabine mechanism of action 在 Sapacitabine, the prodrug of CNDAC, is a nucleoside analog ... 的相關結果
Figure 1. - "Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks" ... <看更多>
sapacitabine mechanism of action 在 sapacitabine (CHEBI:145429) - EMBL-EBI 的相關結果
Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. ... <看更多>
sapacitabine mechanism of action 在 US9872874B2 - Dosage regimen for sapacitabine and seliciclib 的相關結果
A first aspect of the invention relates to a method of treating a ... Sapacitabine has a unique mode of action over other nucleoside metabolites such as ... ... <看更多>
sapacitabine mechanism of action 在 Profile of sapacitabine: potential for the treatment of newly ... 的相關結果
Keywords: AML, elderly, management, sapacitabine. ... Demethylating agents offer a novel mechanism of action, acceptable toxicity profile, ... ... <看更多>
sapacitabine mechanism of action 在 Results of a randomized phase 3 study of oral sapacitabine in ... 的相關結果
... is a rationally designed deoxycytidine analogue with a unique mechanism of action. After oral administration, sapacitabine is converted ... ... <看更多>
sapacitabine mechanism of action 在 TDP1 is Critical for the Repair of DNA Breaks Induced by ... 的相關結果
TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, ... Based on the proposed mechanism of action of CNDAC with formation of a DNA damage ... ... <看更多>
sapacitabine mechanism of action 在 Study of Sapacitabine in Acute Myeloid Leukemia (AML) or ... 的相關結果
Acute Myeloid Leukemia Myelodysplastic Syndromes, Drug: sapacitabine and decitabine (Part 1 - completed) ... Molecular Mechanisms of Pharmacological Action ... <看更多>
sapacitabine mechanism of action 在 Paper: HDAC Inhibition Induces microRNA-182 Which Targets ... 的相關結果
Consequently, efficient HR may offer a potential resistance mechanism to therapy with sapacitabine. Rad51 is a protein plays a critical role ... ... <看更多>
sapacitabine mechanism of action 在 Sapacitabine by Cyclacel Pharmaceuticals for Refractory ... 的相關結果
Sapacitabine target DNA polymerase and acts through a dual mechanism, interfering with DNA synthesis. It is based on genomic technology. ... <看更多>
sapacitabine mechanism of action 在 Improvement of the Antitumor Activity of Poorly Soluble ... 的相關結果
Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin. J. Cancer, 31, 373–380 (2012). 4) ... ... <看更多>
sapacitabine mechanism of action 在 Reduced drug incorporation into DNA and antiapoptosis as ... 的相關結果
The mechanisms of resistance included reduced drug incorporation into ... of its mechanism of action and by overcoming drug resistance. ... <看更多>
sapacitabine mechanism of action 在 萨帕他滨治疗急性髓性白血病的疗效。,Expert Opinion ... - X-MOL 的相關結果
专家意见：Sapacitabine是一种新型核苷类似物，似乎是有前途的AML治疗新药。它的口服生物利用度和可耐受的毒性特征使该药物可用于门诊，特别是对于年 ... ... <看更多>
sapacitabine mechanism of action 在 CNDAC hydrochloride|134665-72-8|MOLNOVA 的相關結果
Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. ... <看更多>
sapacitabine mechanism of action 在 EBioMedicine 的相關結果
MDR is defined as the resistance of cancer cells to multiple chemotherapeutic drugs with different structures and mechanisms of action (7). Abnormal DNA repair ... ... <看更多>
sapacitabine mechanism of action 在 TDP1 deficiency and genomic instability in non-replicating cells 的相關結果
Figure 3: Mechanisms of action of TOP1 inhibitors. ... (2017) 'TDP1 is critical for the repair of DNA breaks induced by sapacitabine,. ... <看更多>
sapacitabine mechanism of action 在 Interactions between miRNAs and Double-Strand Breaks DNA ... 的相關結果
DSB repair occurs through two main mechanisms, ... and mediated oncogenic actions in renal and hepatocellular carcinoma cells [36,37]. ... <看更多>
sapacitabine mechanism of action 在 cmml scientific advisory group - Milken Institute 的相關結果
Table 2: Experimental therapies for CMML. Drug Name(s) Mechanism of Action. Pathway Targeted topotecan sapacitabine birinapant clofarabine. Chemotherapy. ... <看更多>
sapacitabine mechanism of action 在 DNMT3A harboring leukemia-associated mutations directs ... 的相關結果
To investigate the molecular mechanism of sensitivity to ... Whether a methylation-independent mechanism of mutant DNMT3A action might be at ... ... <看更多>
sapacitabine mechanism of action 在 micrornas as predictors of nucleoside analog sensitivity in 的相關結果
Both the concentration and duration of exposure of active triphosphate metabolite of cytarabine are critical for the mechanism of action of this nucleoside ... ... <看更多>
sapacitabine mechanism of action 在 APACITABINE - pdf download - DocSlides 的相關結果
Selected Clinical Studies in Patients with Solid Tumors Sapacitabine - CDK inhibitor. ... 2,3,4 ,5,6 Mechanism of Action Sapacitabine affects DNA synthesis, ... ... <看更多>
sapacitabine mechanism of action 在 Myelodysplastic syndromes: clinical aspects - EHA Library 的相關結果
sapacitabine, an oral deoxycytidine nucleoside analog with a unique mechanism of action that is ... sible mechanism of action of rigosertib in MDS patients. ... <看更多>
sapacitabine mechanism of action 在 Genetic Abnormalities and Challenges in the Treatment of ... 的相關結果
List of Molecules in the Late-Stage Pipeline for Acute Myeloid Leukemia (AML). Molecule. Class. Mechanism of action. Company. Phase (US). Amonafide (AS1413). ... <看更多>
sapacitabine mechanism of action 在 Comprehensive analysis of pyroptotic gene prognostic ... 的相關結果
However, the specific mechanism between pyroptosis and the clinical ... fluphenazine and sapacitabine, and in KLRB1 with nelarabine, ... ... <看更多>
sapacitabine mechanism of action 在 Therapies for acute myeloid leukemia in patients ineligible for ... 的相關結果
Interventions of interest included chemotherapy (decitabine, azacitidine, FLUGA [fludarabine, cytarabine and filgrastim], sapacitabine, ATRA [ ... ... <看更多>
sapacitabine mechanism of action 在 Ovarian Cancer Therapy – Innovative Models Prolong ... 的相關結果
... cell lines suggests that cellular response to carboplatin is an accumulative result of different genes with different mode of actions. ... <看更多>
sapacitabine mechanism of action 在 低甲基化劑Hypomethylating Agent - 最新的百科全書 的相關結果
All of these drugs have primary and acquired mechanisms of resistance, ... that these pathways play pivotal roles in the action of hypomethylating agents. ... <看更多>
sapacitabine mechanism of action 在 Medicines - Horizonscan geneesmiddelen 的相關結果
Acute myeloid leukaemia (AML), isocitrate dehydrogenase-1 (IDH1) mutation - first-line combination therapy. Luspatercept · Sapacitabine ... <看更多>
sapacitabine mechanism of action 在 CNDAC hydrochloride | Cas# 134665-72-8 - GlpBio 的相關結果
Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. ... <看更多>
sapacitabine mechanism of action 在 Role of Rad51 and DNA repair in cancer - OUCI 的相關結果
https://doi.org/10.1016/j.virusres.2018.01.003; Dasari, Cisplatin in cancer therapy: molecular mechanisms of action, Eur J Pharmacol, № 740, с. 364 ... <看更多>
sapacitabine mechanism of action 在 Less Intensive 1 (LI1) Trial: A Randomized Phase 的相關結果
Patients allocated to receive sapacitabine would receive treatment on ... Action. First Incident. Reduce vosaroxin injection dose from 72. ... <看更多>
sapacitabine mechanism of action 在 無題 的相關結果
Couples negril, Jaime alguersuari height, Panasonic cq-c1465n mode d'emploi, ... Elez biberaj albania transition, Nicip tablet side effects, Sudden values ... ... <看更多>
sapacitabine mechanism of action 在 INHIBITORS OF ERK AND METHODS OF USE 的相關結果
[0278] Administration of the compounds of the present invention can be effected by any method that enables delivery of the compounds to the site of action. ... <看更多>
sapacitabine mechanism of action 在 Patent 2816000 Summary - Canadian Patents Database 的相關結果
Sapacitabine, Saredutant, Semagacestat, Teriflunomide, Trabectedin, Ramelteon, Ombrabulin ... The mechanism of action of clopidogrel requires ... <看更多>
sapacitabine mechanism of action 在 無題 的相關結果
Lc ms method development and validation, Insten battery, Empirical asset ... yeah baby song lyrics, Sapacitabine mechanism of action, Lucius cocceius nerva. ... <看更多>
sapacitabine mechanism of action 在 Tovaxin Reduces Disability for Multiple Scelerosis (Clinical ... 的相關結果
Immunology data also appears to support Tovaxin's mechanism of action, ... Cyclacel Reports Phase 2 Survival Data with Sapacitabine. ... <看更多>
sapacitabine mechanism of action 在 TARGETING THE SPLICE FACTOR KINASES SRPK1 AND ... 的相關結果
Both Sapacitabine and LDAC were found to result in a ... Mechanism of action of this compound involves the inhibition of SRSF4 through ... ... <看更多>
sapacitabine mechanism of action 在 International Nonproprietary Names for Pharmaceutical ... 的相關結果
L'OMS n'est pas en mesure de confirmer ces déclarations ni de faire de commentaires sur l'efficacité du mode d'action ainsi décrit. En raison de ... ... <看更多>
sapacitabine mechanism of action 在 What Is a Phase I Clinical Trial? - SlideShare 的相關結果
Phase Purpose Phase I Determine dose Determine side-effects ... and Irinotecan – Sapacitabine and Seleciclib • ER+ Breast Cancer – Cdk 4/6 ... ... <看更多>
sapacitabine mechanism of action 在 Hydroxamate, A Key Pharmacophore Exhibiting a Wide ... 的相關結果
... iron chelators used in clinical I. Mode of action of iron (III) chelators as ... N.; Nishihara, T. Combination of sapacitabine and HDAC inhibitors Novel ... ... <看更多>
sapacitabine mechanism of action 在 Cyclacel Pharmaceuticals Annual Report 2023 - StockLight 的相關結果
seven cohorts relevant to the drug's mechanism of action and informed by the ... patents and patent applications covering sapacitabine, ... ... <看更多>
sapacitabine mechanism of action 在 New Treatments for Metastatic Breast Cancer | Oncohema Key 的相關結果
Sapacitabine and seliciclib in patients with advanced solid tumors. NCT00999401. Sapacitabine and seliciclib in ... Mechanism of action. ... <看更多>
sapacitabine mechanism of action 在 Ton june 2013 issue web by The Oncology Nurse - Issuu 的相關結果
However, based on its mechanism of action and findings in animals, ... Patients received treatment with sapacitabine and seliciclib—2 drugs ... ... <看更多>
sapacitabine mechanism of action 在 2008-2009%20DOM%20Annual%20Report[1].pdf 的相關結果
and side effects of the most widely ... debilitating side effects. ... A Randomized Phase II study of ral sapacitabine in Elderly Patients ... ... <看更多>
sapacitabine mechanism of action 在 Traduction de "cutaneous T-cell lymphoma (CTCL" en français 的相關結果
However, the exact mechanism of action of bexarotene in the treatment of cutaneous T-cell lymphoma (CTCL) is unknown. Cependant, le mécanisme exact de ... ... <看更多>
sapacitabine mechanism of action 在 pegfilgrastim peginterferon alfa-2a: Topics by Science.gov 的相關結果
Ipilimumab and peginterferon alfa-2b are established systemic treatment options for melanoma that have distinct mechanisms of action. ... <看更多>
sapacitabine mechanism of action 在 肿瘤医生APP：肿瘤医生工作和学习必备 - 良医汇 的相關結果
Synthetic lethal targets modulators therapeutics (Satya Pharma). SPEAR T cell therapies (Adaptimmune). DDR pathway protein modulators (Satya Pharma). ... <看更多>
sapacitabine mechanism of action 在 SAPACITABINE - Inxight Drugs 的相關結果
Sapacitabine (also known as CYC-682) is an orally bioavailable 2′-deoxycytidine analog that is in clinical trials for hematologic malignancies and solid ... ... <看更多>
sapacitabine mechanism of action 在 Principles Of Pharmacology Golan 的相關結果
drug actions on the body, and ultimately, ... organized by mechanism of action, with ... clofarabine, cloretazine, sapacitabine,. ... <看更多>
sapacitabine mechanism of action 在 definition of nucleoside analogue by Medical dictionary 的相關結果
... a certain component; it may have similar or opposite action metabolically. ... Cyclacel Pharmaceuticals' Sapacitabine fails to meet primary endpoint in ... ... <看更多>
sapacitabine mechanism of action 在 Sapacitabine | Nucleoside Antimetabolite/Analog - TargetMol 的相關結果
Sapacitabine is a nucleoside analog prodrug with antitumor activity. All products from TargetMol are for Research Use Only. Not for Human or Veterinary or ... ... <看更多>
sapacitabine mechanism of action 在 New Strategies Targeting Cancer Metabolism: Anticancer ... 的相關結果
It has a unique mechanism of action that differ from that of cytarabine. Sapacitabine has potency against leukemia and (myelodysplastic syndromes) MDS. ... <看更多>
sapacitabine mechanism of action 在 Issues in Cancer Epidemiology and Research: 2013 Edition 的相關結果
(2012 Sep 03) University of Texas, H0ust0n: Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand ... ... <看更多>
sapacitabine mechanism of action 在 Acute Leukemia: New Insights for the Healthcare ... - Google 圖書結果 的相關結果
“Sapacitabine is an oral deoxycytidine nucleoside analog with a unique mechanism of action that is different from cytarabine. To define the dose-limiting ... ... <看更多>
sapacitabine mechanism of action 在 The SAGE Encyclopedia of Cancer and Society - Google 圖書結果 的相關結果
To achieve this goal, the novel drug should utilize a mechanism of action that ... II clinical trial using oral sapacitabine, a cytosine nucleoside analog, ... ... <看更多>
sapacitabine mechanism of action 在 AACR 2016: Abstracts 2697-5293 - Google 圖書結果 的相關結果
Sapacitabine, an orally bioavailable prodrug of the deoxycytidine analog, ... confirming the unique action mechanism of CNDAC among nucleoside analogs. ... <看更多>
sapacitabine mechanism of action 在 Drying Limelight Hydrangea - Molly Pollet 的相關結果
We've got a joint account piracetam mechanism of action in stroke And the idea of ... sapacitabine,has activity against a majority of ovarian cancer samples ... ... <看更多>
sapacitabine mechanism of action 在 Sapacitabine, the prodrug of CNDAC, is a nucleoside analog ... 的相關結果
CNDAC has a unique mechanism of action: after incorporation into DNA, it induces single-strand breaks (SSBs) that are converted into double-strand breaks (DSBs) ... ... <看更多>