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#2. Clinically-Relevant ABC Transporter for Anti-Cancer Drug ...
From the previous studies on cancer and multidrug resistance, we know that ABC transporters mainly over-express in poorly differentiated cells ...
#3. Revisiting the role of ABC transporters in multidrug-resistant ...
由 RW Robey 著作 · 2018 · 被引用 879 次 — Ample evidence suggests that the expression of ATP-binding cassette (ABC) transporters, especially the multidrug resistance protein 1 (MDR1, ...
#4. The role of ABC transporters in drug resistance, metabolism ...
We place a special emphasis on the three major groups of ABC transporters involved in cancer multidrug resistance (MDR). These are the classical P-glycoprotein ...
#5. ABC transporters as mediators of drug resistance and ...
由 JI Fletcher 著作 · 2016 · 被引用 317 次 — The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC) transporter family is one of the most widely recognized mechanisms of ...
#6. ABC Transporters, Drug Resistance, and Cancer Stem Cells
ATP-Binding Cassette Transporter Function · Drug Resistance in Cancer Cells · ABC Transporters in Normal Stem Cells.
#7. ABC Transporter Inhibitors in Reversing Multidrug Resistance ...
In addition to their profound physiological and pharmacological functions, ABC transporters play important roles in instigating multidrug resistance (MDR) ...
#8. The roles of the human ATP-binding cassette transporters P ...
The ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp) and ABCG2 are multidrug transporters that confer drug resistance to numerous anti-cancer ...
#9. ABC Transporters and Cancer Drug Resistance - Sigma-Aldrich
The generally accepted mechanism of multi-drug resistance is that the MDR proteins actively expel the cytotoxic drugs from cells, maintaining the drug ...
#10. Multidrug Resistance Protein 1 (MRP1, ABCC1), a ...
Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter*. Susan P.C. Cole.
#11. ABC Transporters Involved in Drug Resistance - ResearchGate
Download Table | ABC Transporters Involved in Drug Resistance from publication: Dean M, Rzhetsky A, Allikmets RThe human ATP-binding cassette (ABC) ...
#12. Mechanisms of multidrug transporters - Oxford Academic
Drug resistance, mediated by various mechanisms, plays a crucial role in the ... Multidrug resistance, Drug transport, ABC transporters, P-glycoprotein.
#13. ATP-binding cassette transporter - Wikipedia
When the ABC transport proteins are overexpressed in cancer cells, they can export anticancer drugs and render tumors resistant.
#14. ATP-binding cassette (ABC) transporter proteins, multidrug ...
Multidrug resistance (MDR) is often a major impediment to successful chemotherapy in the treatment of cancer. A common mechanism for MDR is the ...
#15. ABC multidrug transporters: structure, function and role in ...
Single nucleotide polymorphisms in ABC drug-efflux pumps may play a role in responses to drug therapy and disease susceptibility. The effect of ...
#16. Transcription factors and ABC transporters: from pleiotropic ...
cerevisiae strains were isolated that displayed resistance to a broad range of drugs ...
#17. ABC Transporters in Microorganisms
reviews our knowledge of the ABC proteins found in microbes.” ... reversal of ABC transporter-mediated multidrug resistance in cancer.
#18. Involvement of CjMDR1, a plant multidrug-resistance ... - PNAS
We recently isolated a cDNA encoding a multidrug-resistance protein (MDR)-type ATP-binding cassette (ABC) transporter (Cjmdr1) from berberine-producing ...
#19. Identification of novel inhibitors of the ABC transporter BmrA
A major underlying mechanism of microbial antibiotic resistance is the export of drugs from bacterial cells. Drug efflux is mediated through the action of ...
#20. Association of ABC Transporter With Resistance to FK866, a ...
ATP-binding cassette (ABC) transporter gene ABCB1 and resistance to NAMPT inhibitor FK866 in ... Key Words: ABC transporter, drug resistance, FK866, NAMPT,.
#21. Inhibitors of ABC Transporters and Biophysical Methods to ...
Multidrug resistance, which is caused by the presence and overexpression of ABC transport- ers, represents a serious problem in cancer treat-.
#22. The potential roles of retinoids in combating drug resistance in ...
Furthermore, ABC transporters are highly associated with MDR [31–35]. Members of the ABCB, ...
#23. Human ABC transporter ABCG2/BCRP expression in ...
Various mechanisms are involved in the multidrug resistance of cancer cells, including reduced drug uptake, the efflux of intracellular drugs, ...
#24. Human Multidrug Resistance ABCB and ABCG Transporters
In accordance with this notion, the drug binding region in the MDR-ABC transporters is ...
#25. Multi-target ABC transporter modulators: what next and where ...
multidrug resistance · multi-target · P-gp. Cancer & ABC transporters: the background. Several ABC transporters (e.g., ABCB1 ...
#26. The Multidrug Resistance-Reversing Activity of a Novel ... - MDPI
Human ABCB1 transporter was the first recognized. ABC transporter of which its overexpression could induce drug resistance of cancer cells ...
#27. Multi drug resistance-associated protein (IPR005292) - InterPro
ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems.
#28. Quantitative evaluation of ABC transporter-mediated drug ...
Elevated expression of drug efflux pumps such as multidrug resistant protein-1 (MDR1/ABCB1) and multidrug resistance associated protein-1 (MRP1/ABCC1) in ...
#29. Multidrug resistance protein 4/ ATP binding cassette ...
Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia.
#30. The Role of the Human ABC Transporter ABCG2
human cell lines, at least nine other ABC transporters are known to confer resistance to ... of many of these transporters in clinical multidrug resistance.
#31. potential regulator of ABC transporters in tumor progression
Multidrug resistance (MDR) is responsible for the major causes of failure in cancer chemotherapy, by which tumor cells resistant to a single class of cytotoxic ...
#32. Contributions of Aspergillus fumigatus ATP-Binding Cassette ...
The role of ABC transporters in azole resistance in A. fumigatus is less ... of various ABC transporters to drug resistance in A. fumigatus.
#33. ABC and MFS Transporters: A reason for Antifungal drug ...
This problem is further elevated many folds due to the resistance mechanisms of fungi through which they circumvent the antifungal drugs ...
#34. ABC transporters and the hallmarks of cancer: roles in cancer ...
Cole SPC. Multidrug resistance protein 1 (MRP1, ABCC1), a “multitasking” ATP-binding cassette (ABC) transporter. J Biol ...
#35. Overcoming Multidrug Resistance in Cancer Stem Cells
The principle mechanism of protection of stem cells is through the expression of ATP-binding cassette (ABC) transporters. These transporters serve as the ...
#36. A new twist in ABC transporter mediated multidrug resistance
The two major efflux pump systems are involved in multidrug resistance (MDR): (i) ATP binding cassette (ABC) transporters and (ii) secondary ...
#37. ABC transporter protein and cancer drug resistance | TMJ
One of the most significant factors in cancer drug resistance is efflux transporter activity. ABC (ATP-binding cassette) transporters are widely ...
#38. Effect of multi-drug resistance ABC transporter activity...
Effect of multi- drug resistance ABC transporter activity on their conformation-induced redistribution on membranesEffect of multi-drug ...
#39. ABC Transporters - AK Lectures
This is known as multi-drug resistance or MDR. Multidrug resistance was shown to be a result of the expression of membrane proteins that became known as MDR ...
#40. ATP-binding cassette transporter family
ATP-binding cassette transporters are ubiquitous membrane proteins characterized by active ATP-dependent movement of a range of substrates, including ions, ...
#41. State of the art of overcoming efflux transporter mediated ...
Keywords: Breast cancer; multidrug resistance (MDR); ATP-binding cassette transporters (ABC transporters); inhibitors; natural products ...
#42. A Mutation in Intracellular Loop 4 Affects the Drug-Efflux ...
Multidrug resistance protein Pdr5p is a yeast ATP-binding cassette (ABC) transporter in the plasma membrane. It confers multidrug resistance ...
#43. Prediction and Identification of Drug Interactions with the ...
Abbreviations: ABC, ATP-binding cassette transporter; BCRP, breast cancer resistance protein (ABCG2); BSEP, bile salt export pump (ABCB11); CYP, ...
#44. BmrA (Bacilus subtilis multidrug resistance ABC transporter ...
Purified membrane protein, BmrA (Bacilus subtilis multidrug resistance ABC transporter ATP-binding Protein), for research in antibody development, ...
#45. ABC and MFS Transporters: A reason for Antifungal drug ...
This problem is further elevated many folds due to the resistance mechanisms of fungi through which they circumvent the antifungal drugs.
#46. component systems regulate ABC transporters in antimicrobial ...
pk. Keywords: Two- component system; bacterial signal transduction; ABC transporter; antibiotics resistance. Abbreviations: ABC, ATP- binding ...
#47. Regulation of ABC Transporters by Kinases and Protein ...
Drugs may act as substrates and/or inhibitors of these transporters. ... ABCG2 (breast cancer resistance protein) is a half-transporter that ...
#48. Targeting the multidrug resistance-1 transporter in AML
The multidrug resistance-1 (MDR1) gene product, P-glycoprotein ... The MDR ATP-binding cassette (ABC) transporters comprise one of the ...
#49. Functional analysis of ATP-binding cassette transporter of ...
ATP- binding cassette (ABC) transporters are characterized as multi drug resistant transporters utilizing ATP hydrolysis.
#50. Predicting drug resistance related to ABC transporters using ...
Predicting drug resistance related to ABC transporters using unsupervised Consensus Self-. Organizing Maps. Roger Estrada-Tejedor 1 & Gerhard F. Ecker 2.
#51. EFLUXX-ID® Green multidrug resistance assay kit - ENZ-51029
Measures drug resistance related to activity of all three major ABC transporter proteins. · Single proprietary dye provides quantitative measurements of MDR ...
#52. Substrate Binding and Energy Transduction in a Multidrug ...
This work focuses on an ABC family drug transporter DrrAB found in soil bacterium ... 1.1 Multidrug Resistance and ABC Transporters.
#53. Increased Expression of an ATP-binding Cassette Superfamily ...
The expression of ATP-binding cassette superfamily transporter genes, such as P-glycoprotein/multidrug resistance (MDR) 1 and MDR protein (MRP) 1, ...
#54. ABC transporter protein and cancer drug resistance - ThaiJo
Keywords: ABC transporter protein, Cancer drug resistance, P-glycoprotein, Breast cancer resistance protein, Multidrug resistance-associated ...
#55. <i>Casearia sylvestris</i> essential oil and its fractions inhibit ...
... Candida albicans ABC transporters related to multidrug resistance (MDR) ... This mechanism of unrelated substrates efflux (multidrug resistance) has ...
#56. How to overcome ATP-binding cassette drug efflux transporter ...
This review presents molecular strategies to overcome this type of drug resistance and discusses for each of these strategies their ...
#57. The ABC-type multidrug transport system
A extensive array of Multidrug resistance transporters that extrude drug compounds out of the cell have been identified as a major cause of bacterial drug ...
#58. Characterisation of the Mycobacterium tuberculosis DRRABC ...
The ATP-binding cassette (ABC) transporters have been identified as one ... of ABC transporter systems to the intrinsic drug resistance of M ...
#59. Predicting drug resistance related to ABC ... - Leitir.is
ATP binding cassette (ABC) transporters play a pivotal role in drug elimination, particularly on several types of cancer in which these proteins are ...
#60. ATP-binding cassette transporters restrict drug delivery and ...
Low-affinity ABC transporter drugs are favored candidates ... P-glycoprotein (P-gp; ABCB1), breast cancer resistance protein.
#61. ABC transporters and multidrug resistance - Brown University
Wiley Series in Drug Discovery and Development. Binghe Wang, Series Editor. ABC Transporters and Multidrug Resistance. Edited by. Ahcne Boumendjel.
#62. The Human ATP-Binding Cassette (ABC) Transporter ...
In this paper, we review the current state of knowledge on all human ABC genes in inherited disease and drug resistance. In addition, the availability of the ...
#63. CALIXAR's Membrane Proteins : BmrA Transporter
CALIXAR's BmrA transporter (Bacilus subtilis multidrug resistance ABC transporter ATP-binding Protein) is an efflux protein and ABC transporter that acts as ...
#64. Characterization of the kinetic cycle of an ABC transporter by ...
The conformational dynamics of multidrug resistance protein 1 (MRP1) are tracked in real time by single-molecule fluorescence resonance ...
#65. Multidrug Transporter Inhibitors - Tocris Bioscience
ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families ... Multidrug resistance protein (MRP) 4 inhibitor.
#66. O06967|BMRA_BACSU - UniProt
Multidrug resistance ABC transporter ATP-binding/permease protein BmrA · Bacillus subtilis (strain 168) · EC:7.6.2.- · Gene: bmrA (yvcC) · 589 amino acids ...
#67. miR-106b~25 cluster regulates multidrug resistance in an ...
How cancer cells acquire drug resistance remains to be fully ... Steinbach D and Legrand O: ABC transporters and drug resistance in ...
#68. The study of drug resistance properties of ABCG2 (ATP ...
Introduction: ATP-binding cassette (ABC) transporters are a group of intra membrane proteins that play key roles in the transmission and exchange of vital ...
#69. MDR transporters and other membrane proteins - Institut Curie
ABC (ATP-binding cassette) transporters are membrane transporters that hydrolyse ... Several ABCs confer a multidrug resistance phenotype (MDR) to bacteria ...
#70. 5MKK: Crystal structure of the heterodimeric ABC transporter ...
In this key position, ABC transporters can mediate multidrug resistance in cancer therapy and their dysfunction is linked to various ...
#71. Multidrug-Resistance in Cancer: ABC-Transporters
Alternatively, cancer cells develop resistance by increased expression of multidrug-resistant proteins and altered anti-tumor drug transport ...
#72. Targeting multidrug resistance in cancer by natural ...
MDR is mainly due to the overexpression of ABC transporters which extrude chemotherapeutic drugs outside of cancer cells.
#73. A transport machine -- ATP-binding cassette - Cusabio
How to overcome ABC drug efflux transporter-mediated drug resistance？ ABC Inhibitors; Other. 1. The Structure of ABC.
#74. Role of ABC-Transporters in Epileptogenesis and ...
Definition of Drug Resistance in Epilepsy. Resistance to drug treatment is a critical problem in the therapy of many brain disorders including ...
#75. Compounds Targeting on ABC Transporter-mediated ...
Invention Reference: 11/MED/424. The ability of cancer cells to acquire resistance to multiple drugs, termed multidrug resistance (MDR), ...
#76. Defeating Drug Resistance in Cancer - Michael M Gottesman
ABC (ATP-binding cassette) transporters pump out cytotoxic cancer drugs from cells, preventing them from reaching therapeutic levels.
#77. ABC Transporters: Mutlidrug Transport in Bacterial Infection ...
In human tumor cells, the ABC exporter, P-glycoprotein (Pgp or ABCB1) acts as an ATP-dependent multidrug efflux pump conferring resistance to anticancer drugs, ...
#78. Side Population in Human Lung Cancer Cell Lines and ...
of ABCG2 as well as other ATP-binding cassette transporters and showed resistance to multiple chemotherapeutic drugs. Human telomerase reverse transcriptase ...
#79. ABC Transporters and Multidrug Resistance - rantianingfa34
A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC ...
#80. ABC Transporters and Multidrug Resistance
(2) Classical MDR Defective Drug Effector Pathways* Resistance to Natural product drugs + Alkylating agents − X rays − ABC transporters/drug pumps ...
#81. ABC transporters
Bacterial ABC transporters are essential in cell viability, ... One of these transporters is the multidrug resistance (MDR) protein, ...
#82. Resistance to Targeted ABC Transporters in Cancer
Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res. 2009;22:740–9.
#83. ATP-binding Cassette (ABC) Transporter Video - LabTube
Drug transporters mediate the uptake and efflux of a broad variety of drugs and drug metabolites. Most uptake transporters are members of ...
#84. Massively parallel pooled screening reveals ... - Science
We validated expression of SLC46A3, a lysosomal transporter, as a negative ... nanoPRISM screen integrates drug delivery and omics.
#85. Pdr18 is involved in yeast response to acetic acid stress ...
Among multistress resistance mechanisms is the one mediated by plasma ... to the multidrug resistance (MDR) subfamily of ABC transporters.
#86. Cancer Cell Line Screen Identifies Biomarkers Linked to ...
... carrier (SLC) transporter and the ATP-binding cassette (ABC) families. ... while members of the ABC multidrug resistant subfamily have a ...
#87. ABC Transporters - 40 Years on - 第 260 頁 - Google 圖書結果
... (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. ... Apical ABC transporters and cancer chemotherapeutic drug disposition.
#88. The ABC's of transport, featuring the ABC Transporter
The molecular shape of an ABC Transporter, made of a bunch of ... of the cell in order for the drug to produce its effect on the body.
#89. High Dopamine
Defects in dopamine circuits have been implicated in a wide range of psychiatric disorders, including Parkinson's disease, schizophrenia, drug addiction and ...
#90. Which are major reasons the pediatric population is more ...
Pharmacokinetic differences in newborns and infants affect drug selection ... OATs) and the biliary canaliculi (e.g., ABC transporters MRP2, ...
#91. Indian Predator: The Butcher of Delhi - DiziBOX
... Drifters · Drifting Dragons · Drug Lords · Drunk History · Dublin Murders ... That Dirty Black Bag · The 100 · The A List · The ABC Murders · The Act ...
abc transporter drug resistance 在 Effect of multi-drug resistance ABC transporter activity... 的推薦與評價
Effect of multi- drug resistance ABC transporter activity on their conformation-induced redistribution on membranesEffect of multi-drug ... ... <看更多>