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It was decided to extend this year's war games to eight days after a review of previous exercises concluded they were conducted too hastily, leaving little time for military units involved in the drills to undertake after action reviews, Taiwan's defense chief said Monday.
https://focustaiwan.tw/politics/202104190013
「 週末煮要聽 」
純分享我自己煮飯時會聽嘅歌😊
EP 11: " All Around The World by Lisa Stansfield "
https://youtu.be/JVuuatjHGnY
"All Around the World" is a song recorded by British recording artist Lisa Stansfield for her 1989 album, Affection, which became her biggest hit.
The song received favorable reviews from music critics. Songwriters, Stansfield, Devaney and Morris, received the 1989 Ivor Novello Award for Best Song Musically and Lyrically. "All Around the World" was also nominated for the Grammy Award for Best Female Pop Vocal Performance at the 33rd Annual Grammy Awards. Additionally, Stansfield was nominated for the Grammy Award for Best New Artist.
The single is Lisa Stansfield's only solo No. 1 single (however she also had a No. 1 with Five Live (George Michael and Queen EP)) and first of 8 top ten hits she would achieve in the UK.
Info source: Wikipedia
#泰山自煮 #tarzancooks #週末煮要聽 #Cookaraoke
《原來臍帶除了臍帶血還有臍帶膜？》
有不少讀者都對臍帶的醫療用途有興趣，上回跟大家分享完臍帶血後，今日跟大家講講比較少人聽過的「臍帶膜」。
上回提到過去小Baby出生後，臍帶大多被當做醫療廢物，在過去的三十年臍帶血持續發展，透過幹細胞治療血液類疾病。而近年，除了臍帶血外，科學家發現了原來臍帶外層的膜（Lining）也有潛在的醫療用途。
【何謂臍帶膜（Umbilical Cord Lining Membrane）】
在講解臍帶膜前，先講解一下臍帶的歷史背景。
17世紀英國醫學家Thomas Wharton發現臍帶組織（Stroma）含有一種啫喱狀的物質，將其命名為Wharton's jelly。這層啫喱的作用為防止臍帶血管（靜脈和動脈）交叉（clumping）和提供臍帶的彈性。1991年科學家McElreavey從Wharton's jelly中分離出類似纖維母細胞的細胞（Fibroblast-like cells）[1]，而這些Fibroblast-like cells在2004年被發現是幹細胞的一種 - 間質幹細胞（Mesenchymal Stem Cells MSCs） [2]。自此臍帶不同的組織便成為科學家的研究對象。
隨著臍帶研究的發展，近年科學家發現能夠利用CellOptimaTM 技術從臍帶外層的組織（臍帶膜）裡提取更多的幹細胞 - 除了間質幹細胞（Mesenchymal Stem Cells MSCs）外，還可提取上皮幹細胞（Epthelial Stem Cells EpSCs）［3］。
那麼，這些EpSCs和MSCs幹細胞跟臍帶血的造血幹細胞（Hematopoietic Stem Cells HSCs）有什麼分別呢？
臍帶血的造血幹細胞主要作用是生成為不同的血液細胞，如之前文章提及到的紅血球、白血球和血小板，可用作治療個別血液類疾病如血癌和個別免疫系統疾病。
MSCs幹細胞則可生成為一些組成不同器官如皮膚、軟骨組織、腦部、心臟和肌肉等等的細胞。
EpSCs幹細胞則可生成為一些組成皮膚或空心（Hollow Structure）的器官如腸臟、氣管、膀胱和子宮等等的細胞。
由於MSCs跟EpSCs幹細胞有生成作不同器官的潛能，近年不少科學家紛紛收集臍帶進行研究。
研究發現MSCs幹細胞有以下潛能並正在對這些疾病進行動物實驗和臨床試驗。[4]
1. 心血管疾病如心肌梗塞和心肌無力症
2. 腦神經系統疾病如腦退化症、多發性硬化症和脊柱神經受傷等等
3. 自體免疫系統疾病如一型糖尿病、自體免疫性肝炎、潰瘍性結腸炎、紅斑狼瘡和類風濕性關節炎等等
令人鼓舞的是，根據目前的臨床試驗公怖結果，在自體免疫系統疾病和內分泌疾病方面，移植MSCs幹細胞後，病情有顯著的改善。同時有研究亦發現MSCs幹細胞有較低的免疫原性（Immunogenicity）、相當較能避開人體免疫系統的識別，減低移植排斥反應。現時不少的臨床研究制用此特性，探討將MSCs幹細胞用作異體移植（Allogeneic Transplantation）例如近親甚至免疫不相容（HLA-Mismatch）的外人等[8]， MSCs幹細胞的移植技術的研究開始了二十多年，目前的研究成果相當正面，其低免疫原性的特質在未來能夠怎樣應用在免疫不相容的病人身上實在值得我們期待。[2][5][8]
而EpSCs幹細胞方面，研究發現或許有以下潛在臨床應用 [6][7]
1. 燒傷治療和傷口癒合
2. 一型糖尿病
3. 肝臟衰竭
不過由於有關臍帶膜的研究，並不被歸納為醫療系統常用的治療，現有的應用均為實驗性質。雖然目前研究仍處床試驗階段，但隨著移植的個案越來越多，臍帶膜的幹細胞似乎有著不少的發展潛力。
跟上回提到臍帶血一樣，從收集臍帶膜到儲存臍帶膜及臨床實驗性應用都有嚴謹的要求，例如運送的時間、過程、儲存系統以及國際認證。
近年不少提供臍帶血儲存服務的生物科技公司同時有提供儲存臍帶膜的服務[2]。跟臍帶血一樣，目前並非醫療系統會資助的常見項目，故對一般家庭來可謂一筆大開支。
正在考慮儲存臍帶血或膜的孕婦宜先充分調查不同臍帶生物科技公司的背景、財政狀況、過去的移植紀錄、使用的儲存技術等等。同時，如有任何疑問務必諮詢專家或醫生意見以作informed decision。
【Reference】
[1] Isolation, Culture and Characterisation of Fibroblast-Like Cells Derived From the Wharton's Jelly Portion of Human Umbilical Cord. Stem Cell Biochemical Society Transaction. https://portlandpress.com/biochemsoctrans/article/19/1/29S/81930/Isolation-culture-and-characterisation-of
[2] The Therapeutic Potential, Challenges and Future Clinical Directions of Stem Cells From the Wharton's Jelly of the Human Umbilical Cord. Stem Cell Reviews and Reports. https://link.springer.com/article/10.1007/s12015-012-9418-z
[3] Epithelial and Mesenchymal Stem Cells From the Umbilical Cord Lining Membrane. Cell Transplant.
https://pubmed.ncbi.nlm.nih.gov/24636188/
[4] Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy. Stem Cells international. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019943/
[5]Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells. Cell Transplant. https://pubmed.ncbi.nlm.nih.gov/21054940/
[6] Short review on human umbilical cord lining epithelial cells and their potential clinical applications. Stem Cell Research & Therapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634865/#CR40
[7] Longitudinal In-Vivo Volumetry Study for Porcine Liver Regeneration From CT Data. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. https://ieeexplore.ieee.org/document/6944684
[8] The Importance of HLA Assessment in “Off-the-Shelf” Allogeneic Mesenchymal Stem Cells Based-Therapies. International Journal of Molecular Sciences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888380/
Photo: Internet Photo
#研究分析 #科普系列 #臍帶膜 #上皮幹細胞 #間質幹細胞 #CellOptima #MesenchymalStemCells #EpthelialStemCells
Destiny 2 พากย์ไทย แปลไทย (Steam Version)
เดสตินี 2 (Destiny 2) is an online-only multiplayer first-person shooter video game developed by Bungie. It was released for PlayStation 4 and Xbox One on September 6, 2017, followed by a Microsoft Windows version the following month. The game was published by Activision until early 2019, when Bungie acquired the publishing rights to the franchise. It is the sequel to 2014's Destiny and its subsequent expansions. Set in a "mythic science fiction" world, the game features a multiplayer "shared-world" environment with elements of role-playing games. Like the original, activities in Destiny 2 are divided among player versus environment (PvE) and player versus player (PvP) game types. In addition to normal story missions, PvE features three-player "strikes" and six-player raids. A free roam patrol mode is also available for each planet and features public events as well as new activities not featured in the original. These new activities have an emphasis on exploration of the planets and interactions with non-player characters (NPCs); the original Destiny only featured NPCs in social spaces. PvP features objective-based modes, as well as traditional deathmatch game modes.
Players assume the role of a Guardian, protectors of Earth's last safe city as they wield a power called Light to protect the Last City from different alien races. One of these races, the Cabal, led by the warlord Dominus Ghaul, infiltrate the Last City and strips all Guardians of their Light. The player sets out on a journey to regain their Light and find a way to defeat Ghaul and his Red Legion army and take back the Last City. Like the original Destiny, the game features expansion packs which further the story and adds new content and missions. Year One of Destiny 2 featured two small expansions, Curse of Osiris in December 2017 and Warmind in May 2018. A third, large expansion, Forsaken, was released in September 2018, beginning Year Two with an overhaul on gameplay. The base game and the first three expansions were packaged into Destiny 2: Forsaken Legendary Collection. An annual pass was also available alongside this release, containing three premium content drops for Year Two. Year Three will begin with the large expansion, Shadowkeep, scheduled for October 2019 as a standalone release, not requiring the previous expansions to play. Alongside the expansion will be a version of Destiny 2 called "New Light", a free-to-play re-release of Destiny 2 and the first two expansions.
Upon release, Destiny 2 received generally favorable reviews from critics. The game received praise for its many improvements over its predecessor. The original Destiny received much criticism for its story, but Destiny 2 was praised as having a "more robust story" and an actual fleshed out villain.[3][4] As with the original, gameplay for the most part was also highly praised. Reviews were split on the recategorization of the weapons and the newer activities like the Adventures and Lost Sectors, but praise was unanimous on the exploration of the game world. Changes to PvP were welcomed by some reviewers, though others were critical for the mode lacking player choice. Destiny 2 was nominated for and won various awards, such as at The Game Awards 2017 and Game Critics Awards.
TOYSREVIL Reviews ACORN & NUTTY by Fanny Kao AKA FUFUFANNY, produced by Paradise. First released at the 2017 Edition of the annual Taipei Toy Festival (#onTOYSREVIL: http://bit.ly/2jNVWkp), I had purchased mine from Ozzo Collection (https://www.facebook.com/ozzocollection/), and you can also purchase them online via http://fufufanny.storenvy.com for US$58 per pair.
Acorn is based on Fanny’s art for her first solo show in Taiwan
Featured on TOYSREVL: http://bit.ly/2wApadN
ACORN & NUTTY featured on TOYSREVIL: http://bit.ly/2BgEFul
Fanny’s first vinyl “Lonely Linus” featured #onTOYSREVIL: http://bit.ly/2CFdlqa
Fanny Kao @
http://www.facebook.com/fufufanny.kao
fufufanny@gmail.com
Paradise @
http://www.paradisetoyland.com
http://www.facebook.com/paradisetoyland
Tracks used:
“Working It” by Jingle Punks
“There Ain't No Other Way (Sting)” by Jingle Punks
////////////////////////////////////////
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TOP 10 SEXIEST MEN'S FRAGRANCES | GIRLFRIEND'S CHOICE
Hey guys, it's time for the annual lady's choice for best men's fragrances ever. These are some of the most sexiest fragrances and most complimented fragrances in my collection. Amazing list right here guys, I hope you all enjoy!
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---FRAGRANCES MENTIONED---
10. http://amzn.to/2qQ0ZZl
9. http://amzn.to/2rp77UO
8. http://amzn.to/2sBTgfg
7. http://amzn.to/2niGKBR
6. http://amzn.to/2sBX68k
5. http://bit.ly/2d3iqOR
4. http://bit.ly/2rdyWjV
3. http://amzn.to/2klOmTe
2. http://amzn.to/2rDDrri
1. http://amzn.to/2sBMtlR
MUSIC
https://www.epidemicsound.com/
WHERE I GET MOST OF MY SAMPLES
http://www.luckyscent.com/
https://www.scentsplit.com
MY TOP 10 DESIGNERS RIGHT NOW
1. http://amzn.to/2k59ME9
2. http://amzn.to/2kVuzsW
3. http://amzn.to/2lqfTPw
4. http://amzn.to/2lmqHlI
5. http://amzn.to/2kQv6fX
6. http://amzn.to/2kQtkf0
7. http://amzn.to/2kVuRjj
8. http://amzn.to/2lmE9FY
9. http://amzn.to/2kK9MX1
10. http://amzn.to/2kVlobV
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MY VIDEO SETUP
Camera- http://amzn.to/2kVevr3
Lens- http://amzn.to/2lmrSSe
Microphone- http://amzn.to/2ktZ8VQ
Lighting- http://amzn.to/2ku1KmP
Filmora Video Editing Software http://amzn.to/2k5eWja
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Stay tune for more Top 10 Best Men Fragrances, Most Complimented Fragrances, Best Designer Fragrances, Best Niche Fragrances, Brand Reviews, and much much more.
