Most entrepreneurs start their business full of energy, but some soon find themselves deflated by the realities.
In the spirit of helping you prepare and respond positively, here is a list of the most common new venture founder unexpected realities, with some thoughts on how to mitigate each one:
1. The business seems to be driving you, rather than you driving it.
Learn early how to focus on the things you can do, surround yourself with help rather than helpers, learn to say "no" often, and keep some balance between your business and the other elements of your life.
The startup world is all about causing change and reacting to unknowns, so set your expectations early to deal with it.
2. Managing cash is an overwhelming burden, in good times and bad.
Be more realistic in your projections on both ends, for example, always asking for enough to cover the next 12-month runway, plus a 6-month buffer for your next milestone to include contingencies and time for the next fundraising.
3. One or more key players need extra attention or replacement.
Don't take the "shortcut" of not doing your due diligence on aspiring team members, strategic partners, investors, or vendors. Cheaper in the beginning can be more costly in the long run.
4. Endless pivots are required to keep up with market changes.
No matter how certain you are that your solution, target market, and customer need are well-proven, you are likely wrong, or the world changes by events you could not have anticipated. Thus you need to reduce the extra pain by having a Plan B, and a process for rapid change.
5. Getting to the next level of growth is a constant challenge.
The key here is to plan ahead, nurture a relationship with your favorite venture capitalists, and leverage the growth and assets you already have with other lending and funding organizations. Of course this means taking some smart risks, not resting on your laurels, and continuously updating your business plan and strategy.
---
op by Joy Chiang, Alumni Community Manager of AppWorks
同時也有1部Youtube影片,追蹤數超過42萬的網紅Call Me Duy,也在其Youtube影片中提到,?SẢN PHẨM DUY ĐỀ CẬP? The Inkey List Hyaluronic Acid Serum ►https://shorten.asia/kMh7d7nD ►https://shorten.asia/1CTPmxeJ The Ordinary Hyaluronic Acid...
「buffer solution」的推薦目錄:
- 關於buffer solution 在 AppWorks Facebook 的精選貼文
- 關於buffer solution 在 史丹福狂想曲 Facebook 的精選貼文
- 關於buffer solution 在 尤詡鑫醫師 Dr.Robertson Facebook 的精選貼文
- 關於buffer solution 在 Call Me Duy Youtube 的最讚貼文
- 關於buffer solution 在 Why does pH of a buffer solution change according to ... 的評價
- 關於buffer solution 在 Buffer Solution - Home | Facebook 的評價
- 關於buffer solution 在 Preparation of Buffer Solution (Acidic & Basic Buffer ... - Pinterest 的評價
buffer solution 在 史丹福狂想曲 Facebook 的精選貼文
今天介紹一點基本的酸鹼生理知識。
人體的酶需要在特定的酸鹼值中工作,如果環境太酸或者太鹼,都會影響它們的活動。
人體有幾個很精密的系統把酸鹼值控制在7.35至7.45的範圍。首先,血漿入面有碳酸(carbonic acid)與碳酸氫離子(bicarbonate ions),這個化學系統是一個緩衝溶液(buffer solution),本身就可以對抗酸鹼的變化。當少量的酸被加進溶液中,碳酸氫離子會把它中和掉;當少量的鹼被加進溶液中,碳酸又會把它中和掉,令酸鹼值相對穩定。除了碳酸與碳酸氫離子,血入面還有磷酸、蛋白質等其他緩衝化學系統。
第二,呼吸系統也是一個重要的酸鹼控制機制。當身體的血液變酸,就會刺激化學受體(chemoreceptors)。周邊化學受體位於頸動脈體(carotid body)及主動脈體(aortic body),中央化學受體(central chemoreceptors)則位於延腦(medulla)。當它們偵測到血液變酸,就會透過腦部的呼吸中心刺激肺部加快呼吸,加快排出二氧化碳,減低血液的酸度。反之亦然。
最後,我們的腎臟也會幫助調節酸鹼。當血液的酸度提高,腎臟會減少排出碳酸氫離子,增加排出氫離子,減低血液的酸度。反之亦然。
酸血症(acidosis)或鹼血症(alkalosis)分為呼吸性(respiratory)及代謝性(metabolic)。呼吸性酸鹼失調是由呼吸系統過量或過少換氣,令血液中的二氧化碳含量出現問題引起。代謝性酸鹼失調則是由於腎臟功能失調,或者身體製造或吸收氫離子太多。
要知道人體的酸鹼情況,就要抽動脈的血液做動脈血液氣體分析(arterial blood gas)。如下圖的檢查中,病人有嚴重的呼吸系統問題,令換氣不足,二氧化碳排不部出來。所以血液中二氧化硫非常高,血液也變得很酸。
buffer solution 在 尤詡鑫醫師 Dr.Robertson Facebook 的精選貼文
你知道血液變酸跟你的飲食有關,並不是吃太多的肉而造成血液變酸,而是吃太多的糖...當我們飲食不均衡時,血糖會快速高升再快速下降。比如,一頓這樣的早餐,含有四十四粒方糖。
例如圖片這一餐並沒有油脂和蛋白質減緩這些糖份分解的速度,這麼多的糖份進入體內,會快速讓血糖高升。血糖高升時會快速在體內代謝成二氧化碳,二氧化碳溶於血水後轉成碳酸(CO2 + H2O ↔ H2CO3),再被體內的碳酸酐酶(carbonic anhydrase,CA)這種酵素將碳酸轉成以下形式H2CO3 ↔ H+ + HCO3 -。H+是氫離子,氫離子愈多的溶液(solution)就愈酸,也就是說血液會因此快速變酸。但是,我們的血液平時是呈微鹼的, pH 7.35-7.45 (中性為pH7),因此當血液變太酸或太鹼時,都會傷身,且我們都可能會出現症狀,比如特別睏。
其實我們吃進所有的食物都會代謝成酸,這稱為酸載量(daily acid load),這是為何體內有非常多道酸鹼緩衝系統。比如,蛋白質緩衝系統(protein buffer system)、碳酸緩衝系統(carbonic acid-bicarbonate buffer system)、磷酸鹽緩衝系統 (phosphate buffer system)。就因為吃什麼都會變酸,因此食物分解的速度就決定了它影響血液轉酸的速度。在蛋白質、油脂、碳水化合物三大營養元素中,分解速度最快的要屬碳水化合物,碳水化合物包含所有的植物類食物。植物類食物都含醣 除了高纖蔬菜外,多含高糖。由於緩衝需要的是時間,因此當碳水化合物沒有配著蛋白質和油脂一起吃時,它所含的高糖會快速分解進入血液,使得血糖快速高升,由於速度過快,因此體內的緩衝系統來不及運作,血液變酸。
要血液呈現中性,最好就是飲食均衡!一餐裡要有紹量的澱粉(碳水化合物)、蔬菜、肉蛋(蛋白質),使用好的油(油脂)!這樣吃最均衡也健康~
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buffer solution 在 Buffer Solution - Home | Facebook 的推薦與評價
Buffer Solution. 314 likes · 4 talking about this. Buffer Solution will upgrade your pH. ... <看更多>
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20 mars 2019 - LIKE, SHARE, COMMENT & SUBSCRIBE "DIGITAL KEMISTRY" CLICK CHANNEL LINK: ... ... <看更多>
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Suppose you have a 1.0 L of acetate buffer solution made by 500.0 mL of 1.0 M CHX3COONa solution adding to 500.0 mL of 1.0 M CHX3COOH ... ... <看更多>