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#1. Hedgehog pathway inhibitor - Wikipedia
Hedgehog pathway inhibitors, also sometimes called hedgehog inhibitors, are small molecules that inhibit the activity of a component of the Hedgehog ...
#2. Hedgehog Pathway Inhibition for the Treatment of ... - PubMed
由 R Gutzmer 著作 · 2019 · 被引用 32 次 — Subsequently, inhibitors blocking hedgehog signaling either at the level of Smo (i.e., vismodegib, sonidegib, patidegib, and itraconazole) or via an unknown ...
#3. Hedgehog pathway inhibitors – current status and future ...
Hedgehog pathway inhibitors are a relatively new class of therapeutic agents that act by targeting the proteins involved in the regulation ...
#4. List of Hedgehog pathway inhibitors - Drugs.com
Hedgehog pathway inhibitors target the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors. Hedgehog pathway ...
#5. Hedgehog Pathway Inhibitors: A New Therapeutic Class for ...
由 C Jamieson 著作 · 2020 · 被引用 16 次 — Targeting Hedgehog (Hh) pathway components, such as Smoothened (SMO), is a developing strategy for the treatment of acute myeloid leukemia ...
#6. Hedgehog Pathway Inhibitor Therapy for Locally Advanced ...
Hedgehog pathway inhibitors are an effective, well-tolerated therapy for laBCC and mBCC and have great potential to improve quality of life for ...
#7. Hedgehog signaling inhibitors in solid and hematological ...
Aberrantly activated hedgehog signaling plays a major role in the development of solid and hematological cancer. In recent years, inhibitors have been ...
#8. L-4, a Well-Tolerated and Orally Active Inhibitor of Hedgehog ...
Inhibition of aberrant Hedgehog (Hh) pathway had been proved to be a promising therapeutic intervention in cancers like basal cell carcinoma ...
#9. Effects on basal cell carcinoma-like lesions | PNAS
Identification of a small molecule inhibitor of the hedgehog signaling pathway: ... (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has ...
#10. Inhibition of the Hedgehog Pathway in Advanced Basal-Cell ...
Background Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), ...
#11. Hedgehog Pathway Inhibition - Cell Press
The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors ...
#12. Small‐Molecule Inhibitors of the Hedgehog Signaling ...
Inhibitors of the Hedgehog (Hh) signaling pathway have recently emerged as a promising new class of potential therapeutics for cancer ...
#13. A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs ...
Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the ...
#14. Hedgehog pathway inhibition and the race against tumor ...
For example, mutations that activate the Hedgehog (Hh) signaling pathway drive growth of a variety of cancers including basal cell carcinomas ( ...
#15. Hedgehog Pathway Inhibitors: Clinical Implications and ...
Hedgehog pathways inhibitors ... Vismodegib is a first-generation synthetic molecule that binds to the SMO receptor, thereby inhibiting its action ...
#16. What is the role of Hedgehog (Hh) pathway inhibitors in the ...
A Hedgehog pathway inhibitor (HHI) can be used to treat patients with locally advanced BCC who are not candidates for surgery or radiation therapy, ...
#17. Hedgehog Pathway Inhibitors and Their Utility in Basal Cell ...
Recent advances in the understanding of the Hedgehog (Hh) signaling pathway and its role in BCC pathogenesis, together with the discovery of ...
#18. How Do Antineoplastic Hedgehog Pathway Inhibitors Work?
HOW DO ANTINEOPLASTIC HEDGEHOG PATHWAY INHIBITORS WORK? · They work by slowing down or stopping the growth of cancer cells. · They bind to and inhibit Smoothened, ...
#19. Hedgehog pathway inhibition in advanced basal cell carcinoma
Both vismodegib and sonidegib bind SMO and inhibit the Hh pathway reactivation. Hh, Hedgehog; PTCH1, Patched-1 mutation; SMO, ...
#20. High-Risk Recurrence Basal Cell Carcinoma - Karger ...
Target Therapy: Hedgehog Inhibitors ... Given the diffuse alteration of the Hh pathway in BCC, its inhibitors (HPI) have been studied and approved ...
#21. Efficacy, Safety and Tolerability of Topically Applied LDE225 ...
Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell ...
#22. Practical management of the adverse effects of Hedgehog ...
To the Editor: The Hedgehog pathway inhibitors (HPIs), sonidegib and vismodegib, are indicated for locally advanced BCC or metastatic BCC but have a high ...
#23. Hedgehog Pathway Inhibitors Explored in Advanced Skin ...
There are 2 FDA-approved Hedgehog pathway inhibitors, vismodegib and sonidegib [Odomzo]. They are similar excep that vismodegib is indicated ...
#24. Vismodegib, a Hedgehog Pathway Inhibitor for Adults With ...
Vismodegib is a Hedgehog pathway inhibitor. The Hedgehog pathway is essential to fetal development, but signaling is tightly controlled after ...
#25. Reproducibility of academic preclinical translational ...
The development of Hedgehog (HH) pathway inhibitors for the treatment of cancer over the past two decades offers a case study for understanding ...
#26. A cell identity switch allows residual BCC to ... - Nature
Despite the efficacy of Hedgehog pathway inhibitors in the treatment of basal cell carcinoma (BCC)1, residual disease persists in some ...
#27. Inhibition of the hedgehog pathway for the treatment of cancer ...
Inhibition of the hedgehog pathway for the treatment of cancer using Itraconazole ... Abstract: Itraconazole (ITZ) is an anti-fungal drug that has ...
#28. Hedgehog pathway inhibitor therapy in basal-cell nevus ...
Hedgehog pathway inhibitor therapy in basal-cell nevus syndrome ... Vismodegib, an inhibitor of another member of this pathway, SMO, ...
#29. Hedgehog signaling pathway inhibitors: an updated patent ...
However, SMO mutations or SMO-independent Hh pathway activation raise the need for novel Hh inhibitors. Areas covered: This review describes Hh ...
#30. Macrocyclic Hedgehog Pathway Inhibitors: Optimization of ...
Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the previously ...
#31. Hedgehog Pathway Inhibitors as Neoadjuvant Therapy for ...
Purpose : To report our results using the Hedgehog Pathway Inhibitors (HPI) as neoadjuvant therapy for orbital and periorbital basal cell carcinoma (BCC).
#32. Smoothened Mutation Confers Resistance to a ... - Science
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain ... Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in ...
#33. Utility of Hedgehog Signaling Pathway Inhibition for Cancer
This review discusses the relevance of the Hedgehog pathway in cancers and summarizes the clinical experience thus far with Hedgehog inhibitors.
#34. Dr. Sekulic on the Hedgehog Pathway Inhibitor Vismodegib
2012年8月30日 — Vismodegib is an active inhibitor of the smoothened receptor, which is a key link in the Hedgehog signaling pathway. Overall, smoothened is ...
#35. FDA approves Duarismo as hedgehog pathway inhibitor for AML
On November 21, the FDA approved Duarismo (glasdegib), Pfizer's hedgehog pathway inhibitor, to be used in combination with low dose ...
#36. The Hedgehog Pathway Inhibitor GDC-0449 Alters ...
The Hedgehog Pathway Inhibitor GDC-0449 Alters Intracellular Ca 2+ Homeostasis and Inhibits Cell Growth in Cisplatin-resistant Lung Cancer Cells · Abstract.
#37. Approval of the first Hedgehog pathway inhibitor for Invasive ...
In February 2012, the first hedgehog pathway inhibitor was approved by the FDA. This new drug has been shown to be effective in treating and preventing the ...
#38. Hedgehog Pathway Inhibitors - Prices and Information - GoodRx
Prices for Popular Hedgehog Pathway Inhibitors. GoodRx Fair Price. Erivedge$13,438. VISMODEGIB is a medicine that targets proteins in cancer cells and stops ...
#39. Odomzo (Sonidegib), a Hedgehog Pathway Inhibitor, FDA ...
Odomzo (Sonidegib), a Hedgehog Pathway Inhibitor, FDA Approved for the Treatment of Patients with Locally Advanced Basal-Cell Carcinoma.
#40. Treating BCC With Oral Hedgehog Pathway Inhibitors - HMP ...
Oral hedgehog pathway inhibitors offer treatment options to patients with basal cell carcinoma (BCC). Vismodegib (Erivedge) is the first hedgehog signaling ...
#41. Hedgehog signalling pathway inhibitors as cancer ...
由 TN Trinh 著作 · 2014 · 被引用 35 次 — The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of cell proliferation and differentiation.
#42. Pharmacodynamic and pharmacokinetic neoadjuvant study of ...
The oncological benefit of Hedgehog pathway inhibition in prostate cancer remains unclear. INTRODUCTION. The Hedgehog (Hh) signaling pathway ...
#43. A Single Dose Mass Balance Study of the Hedgehog Pathway ...
Vismodegib (GDC-0449), a small-molecule Hedgehog pathway inhibitor, was well tolerated in patients with solid tumors and showed promising ...
#44. Inhibitory effect of bufalin combined with Hedgehog signaling ...
It indicated that bufalin was able to inhibit migration of HCC-LM3 cells, and the Hh signaling pathway inhibitors enhanced the inhibitory effect ...
#45. Inhibition of Hedgehog signaling by direct binding of ...
CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists Proc. Natl. Acad. Sci. USA June 25, 2019 116: 12986- ...
#46. Efficacy and safety of sonic hedgehog ... - IUPUI ScholarWorks
Serious and life-threatening adverse reactions: As sonidegib is an inhibitor of the sonic hedgehog pathway, like vismodegib, it also is toxic to fetuses and ...
#47. Hedgehog Signaling Inhibitors Products - R&D Systems
Hedgehog Signaling Inhibitors : Products · Cyclopamine · SANT-1 · GANT 61 · Dynarrestin · U 18666A · AY 9944 dihydrochloride · SANT-2 · HPI 1.
#48. Hedgehog Pathway Inhibitors Market: Basal Cell Carcinoma ...
The global hedgehog pathway inhibitors market is consolidated, with the presence of small number of international players accounting for ...
#49. Targeting Sonic Hedgehog Signaling by Compounds and ...
The Sonic hedgehog (Shh) signaling pathway is crucial to embryonic development. ... dietary compounds have shown promise as Shh signaling inhibitors.
#50. Hedgehog Pathway Inhibitor | DrugBank Online
A hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma. Sonidegib, An antineoplastic agent used for the ...
#51. Inhibition of Hedgehog signaling for the treatment of ...
Inhibition of Hedgehog signaling for the treatment of lymphoma and CLL: a phase II study ... Hedgehog pathway inhibition may also have antitumor activity in ...
#52. Sonic hedgehog pathway inhibitor mitigates mouse ... - Elsevier
Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma ... the treatment effect of mouse HCC with Shh inhibitor GDC-0449.
#53. Impact of the Smoothened Inhibitor, IPI-926, on ... - PLOS
A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the ...
#54. Practical Tips for Managing Hedgehog Pathway Inhibitor Side ...
The use of Hedgehog pathway inhibitors is a major advancement in the treatment of locally advanced (laBCC) and metastatic BCC (mBCC), which accounts for one ...
#55. Veratramine, hedgehog pathway inhibitor (ab142376) - Abcam
MW 409.60, Purity > 98%. Potent hedgehog pathway inhibitor. Shows antitumor and antiplatelet aggregation effects in vivo. Centrally active and blood-brain ...
#56. Hedgehog Pathway Inhibition for the Treatment of Basal Cell ...
Recent advances regarding the role of hedgehog signaling in the pathogenesis of basal cell carcinoma and the identification of hedgehog pathway inhibitors ...
#57. Hedgehog Pathway Inhibitors: An Emerging Strategy for ...
Despite its unusual name, the Hedgehog pathway is yielding interesting ... these putative cancer stem cells with a Hh pathway inhibitor, ...
#58. Misactivation of Hedgehog signaling causes inherited ... - JCI
Misactivation of the Hedgehog pathway can cause developmental ... which — through repression of a pathway inhibitor — contributes to the ...
#59. Hedgehog pathway activation in T-cell acute lymphoblastic ...
In T-ALL cell lines, pharmacological inhibition or short interfering RNA–mediated knockdown of SMO or GLI1 led to decreased cell proliferation.
#60. (PDF) The hedgehog pathway inhibitor GDC-0449 shows ...
Background: The hedgehog signalling pathway is vital in early development, but then becomes dormant, except in some cancer tumours. Hedgehog inhibitors are ...
#61. Efficacy of sonic hedgehog inhibitors rechallenge, after initial ...
Background. Smoothened (SMO) inhibitors, blocking the sonic hedgehog pathway, have been approved for advanced basal cell carcinoma (aBCC).
#62. Basal Cell Carcinoma: Hedgehog Pathway Inhibitors and ...
An evolving theme in cutaneous oncology is targeted therapy. Blockade of the hedgehog signaling pathway has been a breakthrough in the management of ...
#63. Hedgehog/Smoothened Signaling Pathways - Selleck ...
Smoothened (Smo) inhibitors used for various assays, some have entered clinical trials, which would be new cancer therapies.
#64. Hedgehog pathway and smoothened inhibitors in cancer ...
Therefore, in the Hh-dependent cancers, the inhibition of two or more oncogenic pathways (including the Hh pathway) with use of a single agent of a suitable ...
#65. Development of Hedgehog Pathway Inhibitors (HPI) in ...
Activated hedgehog signaling (Hh) cascade was first found in basal cell carcinoma but with time it has been found in other major cancer types including me.
#66. Vismodegib and the Hedgehog Pathway Inhibitors - Journal of ...
Vismodegib (Erivedge, Genentech-Roche) is the first in class of Hedgehog pathway inhibitors approved for treatment of metastatic basal cell carcinoma (BCC), ...
#67. Dr. Aleksandar Sekulic on the Hedgehog Pathway Inhibitor ...
Aleksandar Sekulic, MD, PhD, Assistant Professor of Dermatology, Mayo Clinic, Scottsdale, AZ, discusses the Hedgehog pathway inhibitor ...
#68. Glasdegib: A Novel Hedgehog Pathway Inhibitor for Acute ...
Glasdegib is a novel Hedgehog signaling pathway inhibitor approved by the U.S. Food & Drug Administration for the treatment of patients with newly diagnosed AML ...
#69. Discovery of the Hedgehog Pathway Inhibitor
The Waldmann lab discoverd the novel Hedgehog (Hh) Pathway inhibitor Pipinib by cell-based screening. Pipinib selectively inhibits phosphatidylinositol 4-kinase ...
#70. Hedgehog Inhibitors Can Be Life-Altering in Patients With ...
“We used to think that the defects within the hedgehog signaling pathway were ... In development is a second hedgehog inhibitor, sonidegib, ...
#71. Global Hedgehog Pathway Inhibitors Pipeline Insight Report ...
Global Hedgehog Pathway Inhibitors Pipeline Insight Report 2021: Key Products by Pfizer, Pulmatrix, Eli Lilly and Co, Suzhou Kintor ...
#72. Hedgehog Pathway Inhibitors Market to record 12.55% CAGR ...
PRNewswire/ -- The hedgehog pathway inhibitors market size is expected to increase by USD 328.39 mn from 2020 to 2025, registering a CAGR of ...
#73. Inhibition of the Hedgehog pathway in lung cancer
Inhibitors of the hedgehog pathway are effective in patients with basal cell carcinoma and a subgroup of patients with medulloblastoma with ...
#74. The role of the Hedgehog signaling pathway in cancer - bjbms
Several Hh signaling pathway inhibitors, such as vismodegib and sonidegib, have been developed for cancer treatment. These drugs are regarded as promising ...
#75. New small-molecule inhibitors of the Hedgehog signaling ...
Inhibitors of the Hedgehog molecular signaling pathway have emerged in recent years as a promising new class of potential therapeutics for cancer treatment.
#76. Hedgehog Pathway Inhibitors Market To Reach USD 1.06 ...
According to the current analysis of Reports and Data, the Global Hedgehog Pathway Inhibitors Market is expected to reach USD 1.06 Billion ...
#77. Hedgehog pathway activation and epithelial-to-mesenchymal ...
Cross talk between the TGF-β and Hedgehog (Hh) signaling pathways appears to ... a potent and highly specific Hh pathway inhibitor (42), for 4 or 7 days.
#78. Drug Information Soundcast in Clinical Oncology (DISCO)
... carcinoma previously treated with a hedgehog pathway inhibitor or for whom a hedgehog pathway inhibitor (or an HHI) is not appropriate. February 9, 2021
#79. The hedgehog pathway and pancreatic cancer. - Semantic ...
Treatment of a mouse model of aggressive pancreatic cancer with an inhibitor of the hedgehog pathway enhanced tumor sensitivity to ...
#80. Hedgehog signaling pathway | Osmosis
The patched receptor inhibits the embryonic cell from differentiating, but Sonic Hedgehog protein inhibits patched, meaning it inhibits the inhibitor! Without ...
#81. Hedgehog Pathway Inhibitors Market Industry Size, In-Depth ...
Understand the influence of COVID-19 on the Hedgehog Pathway Inhibitors Market with our analysts monitoring the situation across the globe.
#82. Global Hedgehog Pathway Inhibitors Market Trend 2022-2028 ...
Hedgehog pathway inhibitors are small molecules that inhibit the activity of a component of the Hedgehog signaling pathway. This report contains ...
#83. Hedgehog Signaling - 第 520 頁 - Google 圖書結果
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc. Natl. Acad. Sci. USA 106(33), 14132-14137.
#84. Search for 莱芜办文凭多少钱【微☀️919118606】兰溪vaz1
Description: Inhibitor of Hedgehog (Hh) signaling. ... Description: FFA2 allosteric agonist; displays bias for the Gi signaling pathway.
#85. The Hedgehog Signaling Pathway - Genentech
... de Sauvage, VP of Molecular Biology, explains Genentech's role towards understanding the relationship between the Hedgehog signaling pathway and cancer.
#86. The Sonic Hedgehog-Gli pathway regulates dorsal brain ...
... lines consistently express the GLI genes and that cyclopamine, a SHH signaling inhibitor, inhibits the proliferation of tumor cells.
#87. Cemiplimab mechanism of action Current antibody drugs ...
2021 Libtayo® (cemiplimab) approved by the European Commission as the first on or are intolerant to a hedgehog pathway inhibitor (HHI).
#88. 2022 Celebration of Undergraduate Research Poster Sessions
Maxfield Palmer, Effects of Chitin synthesis inhibition on t. ... Rishita Chamarthi, Targeting the Sonic Hedgehog Signaling Pathway as a Therapy for ...
#89. Hedgehog signaling activation in human cancer and its ...
... Rubin LL (2006) The hedgehog pathway and neurological disorders. ... of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal ...
#90. METTL3-mediated m6A modification of STEAP2 mRNA ...
... cancer progress by blocking the Hedgehog signaling pathway and ... we verified that the METTL3-STEAP2 axis functions as an inhibitor in ...
#91. Intellectual Property: Valuation, Exploitation and ...
Cancer—Hedgehog Pathway Inhibitor Licensor: Curis, Inc. Licensee: Genentech, Inc. Royalty: $115 million of milestone payments plus mid- to high-single-digit ...
#92. Tumor Microenvironment: State of the Science
... Liang Y (2012) Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells ... hedgehog signaling pathway: review of smoothened and GLI inhibitors.
hedgehog pathway inhibitor 在 Dr. Aleksandar Sekulic on the Hedgehog Pathway Inhibitor ... 的推薦與評價
Aleksandar Sekulic, MD, PhD, Assistant Professor of Dermatology, Mayo Clinic, Scottsdale, AZ, discusses the Hedgehog pathway inhibitor ... ... <看更多>