關於 p meaning ，我們在網路上蒐集到這些相關的討論、資訊與評價

Its been a while I try out any clear pad in my skincare routine. I have been using Anua Heartleaf 77 Clear Pad for some time. When I first receive the product, I am really liking the product packaging of the product.
.
With this 77% on the packaging, meaning it has 77% of Heartleaf extract Soothing Toner that helps in calm and soothe any sensitive or any redness on the face. Further it has PHA exfoliating that just gently exfoliates dead skin cells to give more even skin tone and texture. Besides that this clear pad also ontains Anti Sebum P (Pinus Palustris Leaf Extract, Evening Primrose Flower Extract, Ulmus Davidiana Root Extract, Pueraria Lobata Root Extract) that helps control sebum secresion and tighten pores.
.
I really like how this one product can helps calms, in the mean time exfoliate but also help on sebum control. On the embossing side of the pad you can use an double cleanser by gently wipe on the face. For any irritated spots, you may put the pad on the spot for 15 minutes. Wipe the entire face once again gently with the opposite side of the pad to further prep the skin.
.
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#anua #anuaskincare #anuaskincareglobal #skincare #kbeauty #clearpad

快樂＝M+P+S

哈佛大學最受歡迎的一堂課，學的是「快樂」。1600人一起上課。可見就算是高材生，還是不懂快樂。

現在不可能去哈佛，但可以在家練習那堂課的精髓。

一起拿出紙、筆。

先寫下三個英文字母：

M

P

S

然後回答三個問題：

M（Meaning）：做什麼事讓我覺得有意義？

P （Pleasure）：做什麼事讓我覺得有樂趣？

S （Strength）: 做什麼事符合我的專長？

三個答案的交集，是快樂的泉源。

我先寫：

M（Meaning）：做什麼事讓我覺得有意義？答案：在疫情中自己繼續學習，也幫助別人成長。

P （Pleasure）：做什麼事讓我覺得有樂趣？答案：看書。認識陌生人，聽他們的聲音，了解他們的故事和觀點。

S （Strength）: 做什麼事符合我的專長？答案：連結不同背景的人，挖掘他們的長處，整合他們的觀點，總結成可以啟發彼此的行動。

三個答案的交集，讓我開始做線上讀書會，疫情中陪大家讀書。

作家、心理學家 XUAN 劉軒 跟我帶大家讀了《更快樂：哈佛大學最受歡迎的一堂課》這本書。錯過當天現場互動的朋友，現在可以在劉軒的podcast中聽到：

https://www.facebook.com/i.am.xuan.liu/posts/347279023428246

邊聽，邊寫下你的MPS，找到交集，開始做，更快樂。

📜 [專欄新文章] Uniswap v3 Features Explained in Depth

✍️ 田少谷 Shao

📥 歡迎投稿： https://medium.com/taipei-ethereum-meetup #徵技術分享文 #使用心得 #教學文 #medium

Once again the game-changing DEX 🦄 👑

Image source: https://uniswap.org/blog/uniswap-v3/

Outline

0. Intro1. Uniswap & AMM recap2. Ticks 3. Concentrated liquidity4. Range orders: reversible limit orders5. Impacts of v36. Conclusion

0. Intro

The announcement of Uniswap v3 is no doubt one of the most exciting news in the DeFi place recently 🔥🔥🔥

While most have talked about the impact v3 can potentially bring on the market, seldom explain the delicate implementation techniques to realize all those amazing features, such as concentrated liquidity, limit-order-like range orders, etc.

Since I’ve covered Uniswap v1 & v2 (if you happen to know Mandarin, here are v1 & v2), there’s no reason for me to not cover v3 as well ✅

Thus, this article aims to guide readers through Uniswap v3, based on their official whitepaper and examples made on the announcement page. However, one needs not to be an engineer, as not many codes are involved, nor a math major, as the math involved is definitely taught in your high school, to fully understand the following content 😊😊😊

If you really make it through but still don’t get shxt, feedbacks are welcomed! 🙏

There should be another article focusing on the codebase, so stay tuned and let’s get started with some background noise!

1. Uniswap & AMM recap

Before diving in, we have to first recap the uniqueness of Uniswap and compare it to traditional order book exchanges.

Uniswap v1 & v2 are a kind of AMMs (automated market marker) that follow the constant product equation x * y = k, with x & y stand for the amount of two tokens X and Y in a pool and k as a constant.

Comparing to order book exchanges, AMMs, such as the previous versions of Uniswap, offer quite a distinct user experience:

AMMs have pricing functions that offer the price for the two tokens, which make their users always price takers, while users of order book exchanges can be both makers or takers.

Uniswap as well as most AMMs have infinite liquidity¹, while order book exchanges don’t. The liquidity of Uniswap v1 & v2 is provided throughout the price range [0,∞]².

Uniswap as well as most AMMs have price slippage³ and it’s due to the pricing function, while there isn’t always price slippage on order book exchanges as long as an order is fulfilled within one tick.

In an order book, each price (whether in green or red) is a tick. Image source: https://ftx.com/trade/BTC-PERP

¹ though the price gets worse over time; AMM of constant sum such as mStable does not have infinite liquidity

² the range is in fact [-∞,∞], while a price in most cases won’t be negative

³ AMM of constant sum does not have price slippage

2. Tick

The whole innovation of Uniswap v3 starts from ticks.

For those unfamiliar with what is a tick:

Source: https://www.investopedia.com/terms/t/tick.asp

By slicing the price range [0,∞] into numerous granular ticks, trading on v3 is highly similar to trading on order book exchanges, with only three differences:

The price range of each tick is predefined by the system instead of being proposed by users.

Trades that happen within a tick still follows the pricing function of the AMM, while the equation has to be updated once the price crosses the tick.

Orders can be executed with any price within the price range, instead of being fulfilled at the same one price on order book exchanges.

With the tick design, Uniswap v3 possesses most of the merits of both AMM and an order book exchange! 💯💯💯

So, how is the price range of a tick decided?

This question is actually somewhat related to the tick explanation above: the minimum tick size for stocks trading above 1$ is one cent.

The underlying meaning of a tick size traditionally being one cent is that one cent (1% of 1$) is the basis point of price changes between ticks, ex: 1.02 — 1.01 = 0.1.

Uniswap v3 employs a similar idea: compared to the previous/next price, the price change should always be 0.01% = 1 basis point.

However, notice the difference is that in the traditional basis point, the price change is defined with subtraction, while here in Uniswap it’s division.

This is how price ranges of ticks are decided⁴:

Image source: https://uniswap.org/whitepaper-v3.pdf

With the above equation, the tick/price range can be recorded in the index form [i, i+1], instead of some crazy numbers such as 1.0001¹⁰⁰ = 1.0100496621.

As each price is the multiplication of 1.0001 of the previous price, the price change is always 1.0001 — 1 = 0.0001 = 0.01%.

For example, when i=1, p(1) = 1.0001; when i=2, p(2) = 1.00020001.

p(2) / p(1) = 1.00020001 / 1.0001 = 1.0001

See the connection between the traditional basis point 1 cent (=1% of 1$) and Uniswap v3’s basis point 0.01%?

Image source: https://tenor.com/view/coin-master-cool-gif-19748052

But sir, are prices really granular enough? There are many shitcoins with prices less than 0.000001$. Will such prices be covered as well?

Price range: max & min

To know if an extremely small price is covered or not, we have to figure out the max & min price range of v3 by looking into the spec: there is a int24 tick state variable in UniswapV3Pool.sol.

Image source: https://uniswap.org/whitepaper-v3.pdf

The reason for a signed integer int instead of an uint is that negative power represents prices less than 1 but greater than 0.

24 bits can cover the range between 1.0001 ^ (2²³ — 1) and 1.0001 ^ -(2)²³. Even Google cannot calculate such numbers, so allow me to offer smaller values to have a rough idea of the whole price range:

1.0001 ^ (2¹⁸) = 242,214,459,604.341

1.0001 ^ -(2¹⁷) = 0.000002031888943

I think it’s safe to say that with a int24 the range can cover > 99.99% of the prices of all assets in the universe 👌

⁴ For implementation concern, however, a square root is added to both sides of the equation.

How about finding out which tick does a price belong to?

Tick index from price

The answer to this question is rather easy, as we know that p(i) = 1.0001^i, simply takes a log with base 1.0001 on both sides of the equation⁴:

Image source: https://www.codecogs.com/latex/eqneditor.php

Let’s try this out, say we wanna find out the tick index of 1000000.

Image source: https://ncalculators.com/number-conversion/log-logarithm-calculator.htm

Now, 1.0001¹³⁸¹⁶² = 999,998.678087146. Voila!

⁵ This formula is also slightly modified to fit the real implementation usage.

3. Concentrated liquidity

Now that we know how ticks and price ranges are decided, let’s talk about how orders are executed in a tick, what is concentrated liquidity and how it enables v3 to compete with stablecoin-specialized DEXs (decentralized exchange), such as Curve, by improving the capital efficiency.

Concentrated liquidity means LPs (liquidity providers) can provide liquidity to any price range/tick at their wish, which causes the liquidity to be imbalanced in ticks.

As each tick has a different liquidity depth, the corresponding pricing function x * y = k also won’t be the same!

Each tick has its own liquidity depth. Image source: https://uniswap.org/blog/uniswap-v3/

Mmm… examples are always helpful for abstract descriptions 😂

Say the original pricing function is 100(x) * 1000(y) = 100000(k), with the price of X token 1000 / 100 = 10 and we’re now in the price range [9.08, 11.08].

If the liquidity of the price range [11.08, 13.08] is the same as [9.08, 11.08], we don’t have to modify the pricing function if the price goes from 10 to 11.08, which is the boundary between two ticks.

The price of X is 1052.63 / 95 = 11.08 when the equation is 1052.63 * 95 = 100000.

However, if the liquidity of the price range [11.08, 13.08] is two times that of the current range [9.08, 11.08], balances of x and y should be doubled, which makes the equation become 2105.26 * 220 = 400000, which is (1052.63 * 2) * (110 * 2) = (100000 * 2 * 2).

We can observe the following two points from the above example:

Trades always follow the pricing function x * y = k, while once the price crosses the current price range/tick, the liquidity/equation has to be updated.

√(x * y) = √k = L is how we represent the liquidity, as I say the liquidity of x * y = 400000 is two times the liquidity of x * y = 100000, as √(400000 / 100000) = 2.

What’s more, compared to liquidity on v1 & v2 is always spread across [0,∞], liquidity on v3 can be concentrated within certain price ranges and thus results in higher capital efficiency from traders’ swapping fees!

Let’s say if I provide liquidity in the range [1200, 2800], the capital efficiency will then be 4.24x higher than v2 with the range [0,∞] 😮😮😮 There’s a capital efficiency comparison calculator, make sure to try it out!

Image source: https://uniswap.org/blog/uniswap-v3/

It’s worth noticing that the concept of concentrated liquidity was proposed and already implemented by Kyper, prior to Uniswap, which is called Automated Price Reserve in their case.⁵

⁶ Thanks to Yenwen Feng for the information.

4. Range orders: reversible limit orders

As explained in the above section, LPs of v3 can provide liquidity to any price range/tick at their wish. Depending on the current price and the targeted price range, there are three scenarios:

current price < the targeted price range

current price > the targeted price range

current price belongs to the targeted price range

The first two scenarios are called range orders. They have unique characteristics and are essentially fee-earning reversible limit orders, which will be explained later.

The last case is the exact same liquidity providing mechanism as the previous versions: LPs provide liquidity in both tokens of the same value (= amount * price).

There’s also an identical product to the case: grid trading, a very powerful investment tool for a time of consolidation. Dunno what’s grid trading? Check out Binance’s explanation on this, as this topic won’t be covered!

In fact, LPs of Uniswap v1 & v2 are grid trading with a range of [0,∞] and the entry price as the baseline.

Range orders

To understand range orders, we’d have to first revisit how price is discovered on Uniswap with the equation x * y = k, for x & y stand for the amount of two tokens X and Y and k as a constant.

The price of X compared to Y is y / x, which means how many Y one can get for 1 unit of X, and vice versa the price of Y compared to X is x / y.

For the price of X to go up, y has to increase and x decrease.

With this pricing mechanism in mind, it’s example time!

Say an LP plans to place liquidity in the price range [15.625, 17.313], higher than the current price of X 10, when 100(x) * 1000(y) = 100000(k).

The price of X is 1250 / 80 = 15.625 when the equation is 80 * 1250 = 100000.

The price of X is 1315.789 / 76 = 17.313 when the equation is 76 * 1315.789 = 100000.

If now the price of X reaches 15.625, the only way for the price of X to go even higher is to further increase y and decrease x, which means exchanging a certain amount of X for Y.

Thus, to provide liquidity in the range [15.625, 17.313], an LP needs only to prepare 80 — 76 = 4 of X. If the price exceeds 17.313, all 4 X of the LP is swapped into 1315.789 — 1250 = 65.798 Y, and then the LP has nothing more to do with the pool, as his/her liquidity is drained.

What if the price stays in the range? It’s exactly what LPs would love to see, as they can earn swapping fees for all transactions in the range! Also, the balance of X will swing between [76, 80] and the balance of Y between [1250, 1315.789].

This might not be obvious, but the example above shows an interesting insight: if the liquidity of one token is provided, only when the token becomes more valuable will it be exchanged for the less valuable one.

…wut? 🤔

Remember that if 4 X is provided within [15.625, 17.313], only when the price of X goes up from 15.625 to 17.313 is 4 X gradually swapped into Y, the less valuable one!

What if the price of X drops back immediately after reaching 17.313? As X becomes less valuable, others are going to exchange Y for X.

The below image illustrates the scenario of DAI/USDC pair with a price range of [1.001, 1.002] well: the pool is always composed entirely of one token on both sides of the tick, while in the middle 1.001499⁶ is of both tokens.

Image source: https://uniswap.org/blog/uniswap-v3/

Similarly, to provide liquidity in a price range < current price, an LP has to prepare a certain amount of Y for others to exchange Y for X within the range.

To wrap up such an interesting feature, we know that:

Only one token is required for range orders.

Only when the current price is within the range of the range order can LP earn trading fees. This is the main reason why most people believe LPs of v3 have to monitor the price more actively to maximize their income, which also means that LPs of v3 have become arbitrageurs 🤯

I will be discussing more the impacts of v3 in 5. Impacts of v3.

⁷ 1.001499988 = √(1.0001 * 1.0002) is the geometric mean of 1.0001 and 1.0002. The implication is that the geometric mean of two prices is the average execution price within the range of the two prices.

Reversible limit orders

As the example in the last section demonstrates, if there is 4 X in range [15.625, 17.313], the 4 X will be completely converted into 65.798 Y when the price goes over 17.313.

We all know that a price can stay in a wide range such as [10, 11] for quite some time, while it’s unlikely so in a narrow range such as [15.625, 15.626].

Thus, if an LP provides liquidity in [15.625, 15.626], we can expect that once the price of X goes over 15.625 and immediately also 15.626, and does not drop back, all X are then forever converted into Y.

The concept of having a targeted price and the order will be executed after the price is crossed is exactly the concept of limit orders! The only difference is that if the range of a range order is not narrow enough, it’s highly possible that the conversion of tokens will be reverted once the price falls back to the range.

As price ranges follow the equation p(i) = 1.0001 ^ i, the range can be quite narrow and a range order can thus effectively serve as a limit order:

When i = 27490, 1.0001²⁷⁴⁹⁰ = 15.6248.⁸

When i = 27491, 1.0001²⁷⁴⁹¹ = 15.6264.⁸

A range of 0.0016 is not THAT narrow but can certainly satisfy most limit order use cases!

⁸ As mentioned previously in note #4, there is a square root in the equation of the price and index, thus the numbers here are for explantion only.

5. Impacts of v3

Higher capital efficiency, LPs become arbitrageurs… as v3 has made tons of radical changes, I’d like to summarize my personal takes of the impacts of v3:

Higher capital efficiency makes one of the most frequently considered indices in DeFi: TVL, total value locked, becomes less meaningful, as 1$ on Uniswap v3 might have the same effect as 100$ or even 2000$ on v2.

The ease of spot exchanging between spot exchanges used to be a huge advantage of spot markets over derivative markets. As LPs will take up the role of arbitrageurs and arbitraging is more likely to happen on v3 itself other than between DEXs, this gap is narrowed … to what extent? No idea though.

LP strategies and the aggregation of NFT of Uniswap v3 liquidity token are becoming the blue ocean for new DeFi startups: see Visor and Lixir. In fact, this might be the turning point for both DeFi and NFT: the two main reasons of blockchain going mainstream now come to the alignment of interest: solving the $$ problem 😏😏😏

In the right venue, which means a place where transaction fees are low enough, such as Optimism, we might see Algo trading firms coming in to share the market of designing LP strategies on Uniswap v3, as I believe Algo trading is way stronger than on-chain strategies or DAO voting to add liquidity that sort of thing.

After reading this article by Parsec.finance: The Dex to Rule Them All, I cannot help but wonder: maybe there is going to be centralized crypto exchanges adopting v3’s approach. The reason is that since orders of LPs in the same tick are executed pro-rata, the endless front-running speeding-competition issue in the Algo trading world, to some degree, is… solved? 🤔

Anyway, personal opinions can be biased and seriously wrong 🙈 I’m merely throwing out a sprat to catch a whale. Having a different voice? Leave your comment down below!

6. Conclusion

That was kinda tough, isn’t it? Glad you make it through here 🥂🥂🥂

There are actually many more details and also a huge section of Oracle yet to be covered. However, since this article is more about features and targeting normal DeFi users, I’ll leave those to the next one; hope there is one 😅

If you have any doubt or find any mistake, please feel free to reach out to me and I’d try to reply AFAP!

Stay tuned and in the meantime let’s wait and see how Uniswap v3 is again pioneering the innovation of DeFi 🌟

Uniswap v3 Features Explained in Depth was originally published in Taipei Ethereum Meetup on Medium, where people are continuing the conversation by highlighting and responding to this story.

👏 歡迎轉載分享鼓掌

#후지이미나 #영화 #버킷리스트

민트들과 다양한 작품에 대해 이야기해보는 시간 무드톡!
그 첫번째 이야기, 영화 "버킷리스트" 지금 시작합니다~

ミントの皆さんとさまざまな作品について話してみる時間、ムードトーク！
その第1話は、映画「最高の人生の見つけ方」、今、始まります〜

Time to talk about various works with mints. Mood Talk!
The first story. The movie "Bucket List" starts now~


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馬的郭正亮今天又罵我笨蛋，我說緊急授權不是應該要緊急狀況存在嗎，可是行政院發言人羅秉成說不缺疫苗啊，既然不缺哪裡有緊急狀況需要授權？

為什麼硬要這個時候硬要通過
我跟你講阿宅你這個就不懂了
我又不懂了糟糕
我跟你講
因為當初衛福部對高端做了採購合約
他有一個但書 對
EUA通過之後才能啟動
就是說之前
你的資金不能用
所以我跟你講那個合約
就是這個合約要啟動
你EUA要通過
那是高端急啊關我屁事
所以我說為什麼要這個時候過嘛
裡面有人在配合他
因為他只要過了
那這個合約就可以到銀行貸款
直接把錢領出來
因為這是國家的合同
那他錢領出來要幹嘛去買乖乖嗎
因為他沒錢了
他當然沒錢他本來股本就不夠

然後第二個當然也包括股價一定漲停
我跟你講今天台康台耀國光高端全部漲停
然後聯亞漲29%
所以我跟你講就是基本上
你要從金融面去理解這件事
就是他怎麼那麼急呀
那第一個就是有人要退場
資金從股市退場
那第二個就是這個公司真的沒錢了
那沒錢了 不是看起來
你給他過了萬一他倒了怎麼辦
不會啦
881乘以500萬是40億 怎麼倒
不是啊
但是他如果真的認真要做三期
他如果認真要做三期錢不夠
真正的挑戰是在哪裡
比如說我們這一波AZ打完大概八月中
那平均現在AZ一天大概打到
十六萬到二十幾萬之間
那你如果高端啟用那一天
那結果打得人突然低於五萬呢
那就當然跑啊廢話 要我我也跑啊
阿宅我跟你講
那個時候才是見真章的時刻
就是表示人民的信任到哪裡嘛對不對
就沒有信任啊
那因為它的瑕疵太多嘛
比如說我隨便舉兩個例子
第一個就是
你明明二期完全解盲是十月二十八號
是 因為要過兩百九十天 我如果沒記錯
就將近六個月
你完全解盲還沒完
那表示副作用還有實際的療效
你都不確知
長期觀察沒看到
結果你就急著在七月二十號就急著讓他過
那是什麼意思啊
而且他通過之後
就可以立即開始製造
他EUA是緊急授權可以開始製造
我跟你講今天柯P講一句話是蠻對的
他說可以允許製造
不等於可以允許接種
對對對不一樣
我覺得柯P講這句話真的是對
那為什麼我要讓你試
我為什麼要當白老鼠
因為他後面規定有個很鳥
我跟你講第一個
我要按部就班罵因為這東西實在太多了
我們有二十一個委員
藏頭不露臉名字比劃生辰八字都不知道
他什麼領域專業你也不知道
他姓什麼你也不知道
他長什麼樣你不知道
他在會場講了什麼話你也不知道
通通都不知道的狀況之下 過了
就怕被噹嘛
你如果有專業你怕被噹個屁
阿宅我再講另外一點
國民黨不是開了一個記者會
公佈了食藥署裡面流出來一些文件
那就講到高端的 本來在六月
有三個時間點的製造成品
那有百分之八十二不合格嘛對不對
這個居然跟緊急授權也沒有關係
因為緊急授權只看他的臨床數據
他的中和抗體效價是不是高於AZ
他的標準就是這樣
那至於我製成的品質優不優良
他不管 你知不知道
他只看數字
這個完全是一個很北爛的東西
全世界哪有這種事
你讓他緊急授權是指
他的中和抗體效價夠了嘛 對不對
可是你怎麼可以允許
這個製作的良率這麼低的公司
然後就放心讓他來製造疫苗來讓我們打
而且你不是說
我已經不是良率的問題
是你今天看到的所有數據
是沒辦法證明他真的有抵抗力的
它的T細胞反應到底怎麼樣
我跟你講沒有錯因為中和抗體大概跟B比較連繫
那T細胞怎麼作用不知道
就是因為會產生保護作用
有B細胞跟T細胞
那T細胞通常都是要體內要觀察
它的實際作用才會知道
就是有看過工作細胞的都知道
T細胞是對抗病毒的時候主要作戰能力
也就是在台灣幼稚園到小學生都看得懂
所以為什麼要做三期就這原因
因為要打到人體裡面要做觀察
而且量要夠大 是
要做三、四萬人
那他現在的問題就在這
所以今天路透社發了一個新聞講的很坦白
他說他的臨床實驗沒做完
然後他用的詞是efficacy data
not available
就efficacy就是效力效能效價
連這個最重要的數字都沒有
他就直接這樣寫
然後說可是台灣的衛福部說這樣
他的文章這樣寫
我這樣講因為這個東西真的很誇張
我們再告訴大家
聯亞跟高端是二階中期解盲
但並沒有二階臨床完成
二階臨床還沒有完成
你就申請EUA還過了
陳時中真的很荒謬
還拿去跟全世界其他比
世界上其他的Moderna Pfizer
Johnson & Johnson然後AZ阿斯特捷利康
都是在三期期中報告已經解盲才申請EUA
他們天差地遠好嗎


而且我還是要講美國這個
我一定要唸一下美國的FDA
都會說他的諮詢委員是經過仔細篩選
有排除掉任何存在利益衝突的人士
以便公眾科學界能夠更了解的
更清楚了解新冠疫苗
FDA官網是把這十八個成員
全部列出來有一個席次從缺
他列出來這些人的背景是
德州休士頓大學醫學院博士
傳染病學教授Hana El Sahly
其他成員有臨床研究、兒科專業
免疫與呼吸疾病病理學
還有行業代表Head of Medical Affairs副總裁
還有FDA的生物製品評估研究中心負責人
聯邦政府指定科學顧問
我講到這裡我就問
請問那二十一個人開會的人是誰
阿亮你知道嗎
不知道
我們就這樣講
而且到底是誰投反對票也不知道
連會議紀錄都沒有連錄音錄影都沒有
阿宅我跟你講一點更離譜的
你記不記得昨天食藥署的吳秀梅
她本來怎麼講
她說十八個人只有一票反對
有一票說要補件對不對
那其他都是同意
那今天改口今天說什麼你知道嗎
今天說十五個人是有條件同意
結果我去查什麼叫有條件 兩個條件
第一個每月都要交安全監測報告
第二個
第二個是一年之後要交出保護效益報告書
可是等等等等等等等
我光聽到這裡我就覺得不太爽
你就快昏倒了
你的保護效益
報告書是奠基於中華民國台灣
這些沒有選擇的國民 來當你的白老鼠
在不情願的狀況下接受注射
我問你一下
假設你就開打了 開打了
假設第一個月第二個月這樣下來
有一堆人打了高端嘛
然後他又確診假設有這種狀況
那他的保護效益就會被質疑
那當然 那你要不要喊停
以AZ的狀況我們都死了那麼多人也不喊停
調查應該是不會停 是嘛
他就要一年之後才要他提保護效益報告
那如果說你明明打一個月打兩個月
然後你明明打了之後還確診
那你不用停下來停打
來檢驗一下你的保護效益嗎
你知道我的意思 我知道
這個問題多核心啊
那我們一定要試完一年
才可以看他的保護效力報告
我們這樣講
這什麼邏輯啊
這個網友講的對
三期的受測者
在所謂的各藥廠的三期臨床裡面是拿錢的
我不但有保險
我還要跟你拿錢
一個人所有成本加一加夯不啷噹大概3萬美金左右
那可能我實際拿到手上也許一萬五
因為還要分給醫生 還要給醫生還有護理師
那現在他在台灣是我中華民國
不只免費 是我政府花錢買的
我們花錢買的東西打自己身上
然後給你做報告然後拿去賣給國外
結果你這樣講好了
高端今天又宣布一個好消息
說我們在巴拉圭找到了一千個人做第三期臨床
這個怎麼叫第三期 笑死人
第三期還有一千人的喔
第三期是三萬到四萬
而且你知道他的內容嗎
他說那一千個也是一樣
一半打高端一半打AZ
這個哪裡是第三期
我跟你講這個狀況就完全的
把台灣的狀況
我不知道他在那邊花了多少錢
你把台灣這種不合理的狀況
搬到國外去的時候
我最後還是要講一件事情
你知道那些人
那十五個人說都要交報告的那些人
我只問一件事情
請問阿亮
如果國會要調查這二十一個人是誰
衛福部可不可以
食藥署可不可以保密為由不公開
今天阿中不是講了嗎
說他要提供去識別化的那個審議的過程
我跟你講我就問一件事情
你說我們網友這個仔細想一想
你是中華民國國民
國家要決定有一樣東西
可不可以打到你身上
結果他決定的過程
是叫二十一個沒有臉不知道名字
連他聲音是什麼都不知道
你也不知道他有沒有利益糾葛
而且阿宅我嚴重懷疑這二十一個
可能都打了AZ或莫德納
對啊 不然這二十一個人要不要全打高端
他也不可能
那結果我們在一個不公開不透明的黑箱裡面
決定了中華民國的國民要花多少錢
買這個五百萬劑的疫苗
然後打到我們身上
那你看這個東西到底對不對

我就問阿亮一件事情
你政治學博士
請問什麼時候憲法高度的監督
立法監督行政權力怎麼會低於民法
沒這回事
我們所有的機密預算
都必須在立法院開機密會議
來審查 那對不起疫苗採購不是機密採購
這個是主計處的定義
對主計處已經講了
所以根本就是胡說八道
而且還沒完
他連著二十一個人資料公佈都要去識別化
我就問一件事情
這二十一個人如果是專家
為什麼不敢堂堂正正的面對大家
你今天做了一個決定
然後你說不好意思
我不能露臉我不方便
然後陳時中還說
我怕他們不能暢所欲言
這是國家的政策你說不能暢所欲言
你以為是在酒店叫小姐
你不能暢所欲言不好意思
而且如果是獨步全球的台灣創新
你不是應該要很驕傲嗎
對啊你講出來啊
你到時候告訴全世界
中華民國台灣的高端疫苗用的是
immuno-bridging就是免疫橋接
就是我就是我李秉穎弄的
我叫全世界給我一個諾貝爾獎
就不敢啊
你講到這四個字才令人火大
他說日本也在搞免疫橋接
那到底是怎麼樣
今天風傳媒登了一篇文章
他說日本人家也做非劣性的比較
非劣性比較不等於免疫橋接
他等於是設定一個疫苗來做比較
比如說高端比AZ
人家日本人就很老實
比如說第一三共製藥
因為他是要做mRNA
那他就老老實實的去對比
輝瑞就BNT或者是莫德納
那請問你高端不是做次蛋白疫苗嗎
你為什麼不去對比Novavax呢
你應該要比同級疫苗
你做的是腺病毒就比AZ
為什麼去對比AZ這種腺病毒疫苗呢
我們還是要講
但是之前不是有側翼講說
沒有啊他們做的是類似
我們的免疫橋接的非劣性實驗
我先這樣講
non-inferiority原來都是
大部分是在藥學裡面
藥學裡面的概念就是
舊藥可能有一些副作用或是比較貴
那我今天做了一個新藥
我必須要證明我的新藥
並不比它inferior
就是並沒有比它劣等
也就是我證明我的效能在它以上
那我就有必要做這個新藥
病患就有可以考慮買我的藥
我也許比較便宜也許比較沒有副作用
所以non-inferiority是要經過臨床實驗
不是單純數據在比
你也許中間會有拿抗體或是數據在比
但是你要做non-inferiority
你可以去看藥學的研究報告
都要做臨床
我問過陳秀熙教授
這個如果要做的準
高端要比AZ他說要做十三萬
要做這麼多

樣本要做到十三萬
根本不可能
我們姑且不要講十三萬你做不到
那你為什麼選AZ呢
你是選那個比較好吃的 最差的
因為這個邏輯我再幫阿亮解釋一下
我跟你講我們的網友在我們的教育之下
大概已經變成全世界
國民對疫苗的常識平均了解率已經最高了
AZ目前來講在第一劑第二劑的注射來講
相對它的efficacy是在所有疫苗裡面比較低的
所以你今天Novavax可以超過九成
次蛋白Novavax系列可以超過九成的時候
你高端也做次蛋白 為什麼你的
我們就算高端做的是non-inferiority
就是不比它藥劣的非劣性實驗的時候
為什麼不挑Novavax
你為什麼不挑比較高的你要挑一個AZ
那AZ我們還是要講
各位我對AZ都沒有特別的意見
但它就是一個比較早期的
人類對抗新冠病毒最早的一個武器
最早的武器一定不夠完美
可是現在有個狀況是你拿這個東西來比
而且我們要特別講
我再唸一遍
Daiichi Sankyo's next trial is
expected to test non-inferiority
meaning that the goal is to show
the company's new treatment matches or
outperforms those made by Pfizer and Moderna
also mRNA shots
in terms of efficacy
Details of the study are being ironed
out with the health ministry
就是他還在跟厚生勞動省在討論要怎麼做
但是他們講的很明白
我今天做mRNA我的efficacy就一定是跟mRNA比

《Cope with Life》
曲：黎曉陽
詞：黎曉陽

Kill a day
Another day you knew it's not the only way
If you look another side
Maybe you'll find your way in time

What is wrong, and what is right?
What is the meaning of our lives?
And I've been spending all my time
Tried to compromise

I wanna cry
I'm just searching for a paradise
Looking for a place to hide or a place to cry
Try to cope with life
I wanna try
I'm just searching for a paradise in life
Give me time
A paradise I'll find

What is wrong, and what is right?
What is the meaning of our lives?
And I've been spending all my time
Tried to compromise

I wanna cry
I'm just searching for a paradise
Looking for a place to hide or a place to cry
Try to cope with life
I wanna try
I'm just searching for a paradise in life
Give me time
A paradise I'll find

I wanna cry
I'm just searching for a paradise
Looking for a place to hide or a place to cry
Try to cope with life
I wanna try
I'm just searching for a paradise in life
Give me time
A paradise I'll find

Give me time
A paradise
I'll find

#黎曉陽 #CopeWithLife
#谷Live #香港音樂人 #香港製造 #MadeInHongKong #廣東歌 #香港人撐香港音樂 #撐廣東歌撐谷Live #香港音樂 #StudioLive
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