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在cptac這個產品中，有2篇Facebook貼文，粉絲數超過7萬的網紅臨床筆記，也在其Facebook貼文中提到， #lung #cancer #tw #omics Integrative Proteomic Characterization of Human Lung Adenocarcinoma 2020 https://www.sciencedirect.com/…/a…/abs/pii/S00928...
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cptac 在 臨床筆記 Facebook 的精選貼文

臨床筆記 By 臨床筆記

2020-09-25 07:55:58 有 19 人按讚
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#lung #cancer #tw #omics
Integrative Proteomic Characterization of Human Lung Adenocarcinoma 2020
https://www.sciencedirect.com/…/a…/abs/pii/S0092867420306760

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma 2020
https://www.sciencedirect.com/…/artic…/pii/S0092867420307443

Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression 2020
https://www.sciencedirect.com/…/artic…/pii/S0092867420307431

肺癌傳統被認為與吸菸畫上等號，不過，臺灣的不吸菸肺癌患者卻比吸菸者多。中央研究院化學研究所陳玉如所長、中研院楊泮池院士與跨單位研究團隊以蛋白基因體技術建立臺灣早期肺癌病人的多體學大數據，找到不吸菸肺癌患者可能的致病機制。研究主要有三個發現，首先是肺癌和人體體內APOBEC突變特徵的高低、其次與致癌物的曝露有關；最後更發現一個從未被發現的新亞型肺癌，及其致癌基因突變的差異，有助早期發現臨床潛在的高風險肺癌患者。

研究主持人陳玉如表示，「這是東亞第一套結合深度多體學大數據及完整臨床資料，深度解析不吸菸肺癌成因的研究成果」，也是美國臨床蛋白基因體學腫瘤分析聯盟（CPTAC）首次和國際聯盟團隊（臺灣）攜手合作，以蛋白基因體學揭開臺灣及美國病人肺癌生物學的面紗。臺美二個獨立成果於今（2020）年7月9日同步發表在國際頂尖期刊《細胞》《Cell》上，並共同榮登本期雜誌封面。

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這裡是心臟內科及重症專科醫師 林世崇的醫療筆記部落格，提供實用的臨床醫療資訊，歡迎分享！
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cptac 在 中央研究院 Academia Sinica Facebook 的最佳貼文

中央研究院 Academia Sinica By 中央研究院 Academia Sinica

2020-07-17 17:42:20 有 1,032 人按讚
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🚭不抽菸怎還會得肺癌？


肺癌是全球癌症死亡的主因，即使藥物治療近年有長足的進展，5年存活率仍低於20％，目前仍是國人癌症死亡頭號殺手😱

‼本院最新研究：臺灣有一半以上的肺癌病患並不吸菸，超過 9 成得肺癌的女性也都不抽菸，與 #體內酵素突變 大有關係，而且近十年有年輕化的趨勢，研究成果發表在🌏國際期刊《細胞》《Cell》上，並榮登本期封面‼

_______________________________

本院化學所陳玉如特聘研究員、臺大醫學院內科教授楊泮池（本院院士）與跨單位研究團隊以 #蛋白基因體技術 建立東亞第一套結合深度多體學大數據及完整臨床資料，深度解析 #不吸菸肺癌患者 可能的致病機制，研究有三個重要發現⭐⭐⭐

#發現一
✅肺癌與人體內酵素APOBEC 突變特徵的高低有關
罹肺癌患者中，74％從未吸菸年輕女性（小於60歲）和所有無肺癌表皮生長因子受體（EGFR） 突變的女性患者的APOBEC突變特徵程度較高，可能為女性早期肺癌的驅動因素，可能成為早期診斷和免疫治療的潛在生物標誌物。

#發現二
✅與生活中致癌物有關
暴露於致癌物（吸菸、毒化物、油煙、防腐劑、空汙、金屬化合物等）也會引起基因突變，其中年長女性（大於70歲）突變程度較高。化學致癌物代謝和解毒過程及特定途徑的活化可能影響腫瘤癌化、惡化和免疫調節異常。不過確切致癌物分子有待未來進一步研究鑑定。

#發現三
✅發現新亞型肺癌，透過惡性特徵發現早期罹癌患者
臺灣肺癌患者在EGFR基因上會發生Del19和L858R二種突變，若發生L858R突變，存活率較低。此次將肺腺癌分為五個亞型，其中有一個從未被發現的「類晚期」亞型的早期肺癌。此亞型可區分二種突變的的 #惡性特徵　差異。因此，臨床醫師未來有機會可藉判斷有無此類惡性特徵，發現早期肺癌患者，提供密集觀察和選擇適合佐劑加以治療。
　　　　　　　　　　　　　　　
此次成果為臺美合作「癌症登月計畫」的重要里程碑，是美國臨床蛋白基因體學腫瘤分析聯盟（CPTAC）#首次 和國際聯盟團隊（臺灣）攜手合作發表研究成果。透過跨國族群癌症病人的大數據分享及比較，可更精確探討亞洲非抽菸族群致癌機制、檢測及治療的線索，加速癌症精準醫療的實現。除中研院之外，由臺灣大學、臺北醫學大學、臺中榮總提供病人檢體、臨床數據及檢測技術等。研究經費主要來自科技部、中研院及臺灣大學。

#中研院 #化學所 #陳玉如 #癌症登月計畫
#東亞第一套解析不抽菸肺腺癌之多體學大數據
#肺癌 #蛋白基因體 #APOBEC #Cell #封面

🔺論文全文：https://reurl.cc/626v1y
🔺更多細節：https://www.sinica.edu.tw/ch/news/6591
____________________________________

Two new studies released July 9th, 2020 in Cell unravel the biology of lung adenocarcinoma (LUAD) using a suite of molecular techniques that, combined, provide a more complete picture of the disease than ever before. Using a diverse cohort of smokers and non-smokers, male and female, from around the world, researchers from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and the International Cancer Proteogenome Consortium (ICPC) draw out a clearer understanding of LUAD tumor progression, identify biomarkers, and propose alternative therapeutic targets.

Although strongly associated with smoking, significant populations of never-smokers also develop lung cancer. While never-smokers account for approximately 20% of lung cancer patients in the United States, in Taiwan more than 50% of patients are never-smokers, and many with early onset of the disease. The high number of East Asian LUAD never-smokers presented an opportunity for the ICPC-Taiwan team, led by Drs. Yu-Ju Chen and Pan-Chyr Yang with colleagues from Academia Sinica, National Taiwan University, Taipei Medical University, Taiwan and The Institute of Cancer Research, UK, to take a closer look at the mechanisms of this disease in 103 East Asian patients with a focus on early stage.

🔺More: https://reurl.cc/0o3aAA

#lungadenocarcinoma #LUAD #CPTAC #ICPC #AcademiaSinica #AS #Lungcancer

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這裡是由【中央研究院媒體小組】經營的平台，作為中研院好朋友們交流互動用，幾點注意事項還請粉絲們彼此提醒喲！ ＊發文請盡可能與學術研究、學術活動相關，勿濫用平台打廣告。 ＊有疑慮要發問，請保持基本禮貌，尊重自己也尊重別人。 ＊歡迎各種評論，但禁止謾罵或人身攻擊等，違者將隱藏、刪除貼文或封鎖帳號。 ＊有非關本文的意見，請善用「塗鴉牆」或「私訊」，發文下明顯不相干留言將隱藏或刪除，保持版面一致性。
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cptac 在 コバにゃんチャンネル Youtube 的最讚貼文

コバにゃんチャンネル By コバにゃんチャンネル

2021-10-01 13:19:08 有 9 人看過 有 1 人喜歡
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コバにゃんチャンネル

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コバにゃん☆です?
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cptac 在 大象中醫 Youtube 的精選貼文

大象中醫 By 大象中醫

2021-10-01 13:10:45 有 0 人看過 有 0 人喜歡
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長照是一個劇變的旋轉舞台 百年難得一見 沒有準備的人 被旋轉舞台甩出去 不是坐下就是躺下 而大象中醫是太極的推手 推動著旋轉舞台 讓 所有爬不起來的人 背後有一股推手力量 支撐再站起來
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cptac 在 大象中醫 Youtube 的最佳解答

大象中醫 By 大象中醫

2021-10-01 13:09:56 有 0 人看過 有 0 人喜歡
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長照是一個劇變的旋轉舞台 百年難得一見 沒有準備的人 被旋轉舞台甩出去 不是坐下就是躺下 而大象中醫是太極的推手 推動著旋轉舞台 讓 所有爬不起來的人 背後有一股推手力量 支撐再站起來
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