由 SR Kimball 著作 · 1999 · 被引用 422 次 — eIF2 plays a central role in the maintenance of what is generally considered a rate-limiting step in mRNA translation. In this step, eIF2 binds GTP and ...
Pathway Description: The eIF2 initiation complex integrates a diverse array of stress-related signals to regulate both global and specific mRNA translation.
由 SR Kimball 著作 · 1999 · 被引用 422 次 — eIF2 plays a central role in the maintenance of what is generally considered a rate-limiting step in mRNA translation. In this step, eIF2 binds GTP and ...
In eukaryotic translation initiation, the eIF2·GTP/Met-tRNAi Met ternary complex (TC) binds the eIF3/eIF1/eIF5 complex to form the multifactor complex (MFC), ...
Here, we show in mammalian cells that induction of the eIF2 signaling pathway occurs following infection with bacterial pathogens and that, consistent with ...
eIF2 -alpha Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal ...
Although both of these proteins function in binding initiator tRNA to the 40S ribosomal subunit, the eIF2 complex requires GTP, whereas the EIF2A protein ...
This entry represents the C-terminal domain of the gamma subunit of eukaryotic translation initiation factor 2 (eIF2-gamma) found in Eukaryota and Archaea.
#13.
All Regulation of eIF2 Antibodies Research Areas - ABclonal
#14.
Human Phospho-eIF2 alpha (S52) Antibody MAB39971 - R&D ...
Detects human Phospho-eIF2 alpha (S52) in ELISAs and Western blots. Source. Monoclonal Rat IgG2B Clone # 849159. Purification. Protein A or G ...
#15.
Dynamic cycling of eIF2 through a large eIF2B-containing ...
These results implicate a defined cytoplasmic center of eIF2B in the exchange of guanine nucleotides on the eIF2 translation initiation factor. A focused core ...
#16.
The role of host eIF2α in viral infection | Virology Journal
eIF2, which is required for the initiation of most eukaryotic translation (Fig. 1), mediates the binding of Met-tRNAi Met and the ribosomal ...
#17.
EIF2 beta Overexpression Lysate (NBL1-10187) - Novus ...
Western Blot: EIF2 beta Overexpression Lysate (Adult Normal) [NBL1-10187] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right ...
#18.
Combinatorial analysis of translation dynamics reveals eIF2 ...
Although eukaryotic initiation factor 2 (eIF2), eIF2A and eIF2D have previously been shown to contribute to translation initiation at near- ...
Alternative Name: Eukaryotic translation initiation factor 2 subunit α. Host: Rabbit. Immunogen: Synthetic peptide corresponding to a portion of rat eIF2-α.
#21.
Recycling of eIF2:GDP - Reactome
eIF2B is a guanine nucleotide releasing factor required to cause GDP release so that a new GTP molecule can bind and activate eIF2. Phosphorylated eIF2:GDP ...
#22.
Total-EIF2 alpha HTRF kit I Cisbio
The Total EIF2 alpha cellular assay monitors total EIF2 alpha and is used as a normalization assay with the phospho-EIF2 alpha kit.
#23.
eIF2 independently binds two distinct eIF2B subcomplexes ...
Its activity is inhibited in response to starvation or stress by phosphorylation of the α subunit of its substrate, translation initiation factor eIF2, ...
#24.
eIF2 alpha antibody Western E0157 - Sigma-Aldrich
Anti-EIF2, Anti-Eukaryotic translation initiation factor 2, subunit 1, Anti-EIF2S1, Anti-eIF-2A. NACRES: NA.41. Pricing and availability is not currently ...
#25.
6I3M: eIF2B:eIF2 complex, phosphorylated on ... - RCSB PDB
Phosphorylation of the translation initiation factor eIF2 alpha at a conserved serine residue mediates translational control at the ISR core ...
#27.
Regulation of eIF2 activity. The guanine nucleotide-exchange ...
eIF2 is a heterotrimeric complex composed of three proteins: eIF2 α , eIF2 β and eIF2 γ [2]. The tRNA can only interact with eIF2 once its eIF2 γ subunit is ...
Key pathways of eIF2 activity regulation are phosphorylation of eIF2S1 and phosphorylation of Eukaryotic initiation factor 2 (eIF2B) by some protein kinases.
#29.
A Retrospective on eIF2A—and Not the Alpha Subunit of eIF2
However, subsequent identification of a heterotrimeric 126 kDa factor, eIF2 (α,β,γ) ... of inhibition of eIF2 activity (eIF2α-phosphorylation), or its absence.
#30.
Human eIF2 alpha Antibody (AF3997) | Bio-Techne
Human eIF2 alpha Antibody. Catalog # AF3997. Citations (2). (2). Datasheet / COA / SDS. Detection of Human eIF2a antibody by Western Blot. (2).
#31.
How phosphorylation of eIF2 reduces protein synthesis | RIKEN
RIKEN researchers have found that the unphosphorylated and phosphorylated forms of eIF2 bind in completely different ways to eIF2B, ...
#32.
Poliovirus Switches to an eIF2-Independent Mode of ...
Phosphorylation of eIF2α turns eIF2 into a competitive inhibitor of eIF2B ... We found that eIF2-independent translation is not an inherent ...
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to ...
#34.
eIF2 α Antibody | SCBT
Buy eif2 alpha antibodies from Santa Cruz Biotechnology, Inc. Monoclonal antibodies are available to most protein immunogens.
#35.
Translation of 5′ leaders is pervasive in genes resistant to ...
This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2).
OverviewProduct Name eIF2 alpha antibody Product Number IR133-535 Gene Description eukaryotic translation initiation factor 2, subunit 1 alpha, ...
#37.
Inbuilt Tendency of the eIF2 Regulatory System to Counteract ...
Eukaryotic initiation factor 2 (eIF2) plays a fundamental role in the regulation of protein synthesis. Investigations have revealed that the ...
#38.
Impact of translation initiation factor eIF2-a phosphorylation ...
The dephosphorylation of eIF2-a though the induced expression of Ppp1r15a (GADD34), which forms a functional complex with protein phosphatase 1 (PP1) and ...
#39.
A Yeast Purification System for Human Translation Initiation ...
We purify human eIF2 and the C-terminal domain of human eIF2Bε using affinity chromatography from engineered yeast cells and find that both ...
324892 Sigma-AldricheIF2-GTP-tRNAi Met ternary complex Inhibitor, BTdCPU - CAS 1257423-87-2 - Calbiochem.
#41.
The structural basis of translational control by eIF2 ...
Phosphorylation of the translation initiation factor eIF2 alpha at a conserved serine residue mediates translational control at the ISR core. To provide insight ...
#42.
Crystal structure of eIF2B and insights into eIF2 ... - FEBS Press
Eukaryotic translation initiation factor 2 (eIF2), a heterotrimeric G protein consisting of the α, β, and γ subunits, primarily functions to ...
#43.
Evidence That Ternary Complex (eIF2-GTP-tRNAi Met)
Environmental stress-induced phosphorylation of eIF2α inhibits protein translation by reducing the availability of eIF2-GTP-tRNAiMet, the ternary complex ...
#44.
eIF2A/eIF2 alpha Protein Overview - Sino Biological
EIF2A should not be confused with EIF2-alpha (EIF2S1; 603907), a subunit of the critical trimolecular translation initiation complex EIF2.
#45.
The translation initiation factor eIF2{beta} is an interactor of ...
Site-directed mutagenesis showed that eIF2{beta} contains, in addition to an ... the dephosphorylation of glycogen phosphorylase and eIF2{alpha} (Ser51) by ...
#46.
The NLRP3/eIF2 axis drives cell cycle progression in acute ...
The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemia. Michela Luciano, Constantin Blöchl, Julia Vetter, ...
Rabbit monoclonal antibody anti-eIF2 Alpha is suitable for use in Western Blot.
#48.
eukaryotic initiation factor eIF2 binding Gene Ontology Term ...
Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation. Parent Terms: is-a translation ...
#49.
EIF2A / EIF2 Alpha - LSBio
EIF2A / EIF2 Alpha. eukaryotic translation initiation factor 2A, 65kDa. Functions in the early steps of protein synthesis of a small ...
#50.
An eIF2α-binding motif in protein phosphatase 1 subunit ...
This eIF2 recycling step is an important control point in the translation pathway. Phosphorylation of eIF2α converts eIF2 from a substrate to a ...
#51.
Correction of eIF2-dependent defects in brain protein ...
This step is tightly regulated by phosphorylation of eIF2 on its α subunit (eIF2α-P), which inhibits the GEF activity of eIF2B and attenuates global translation ...
#53.
Coping with stress: eIF2 kinases and translational control
In response to environmental stresses, a family of protein kinases phosphorylate eIF2 (eukaryotic initiation factor 2) to alleviate cellular ...
#54.
EIF2 ALPHA ELISA Kits | Biocompare
ELISA kits for the study of the target, EIF2 ALPHA are available in ready-to-use formats. The protein is also known as eukaryotic translation ...
#55.
Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an ...
Central to the changes in gene expression, eIF2 phosphorylation also enhances translation of ATF4, a transcriptional activator of genes subject to the ...
#56.
Translational Control in Health and Disease - 第 12 頁 - Google 圖書結果
its binding pocket on the g subunit.57 In addition, the nucleotides in the anticodon stem also provide stability of the eIF2–Met-tRNAi complex bound to the ...
#57.
Soil Survey of Clermont County, Ohio - Google 圖書結果
Ankale Mr & B fifmee ES МkB 520 000 FEETI 520 000 FEET MgA MkA EIF2 \ / МКА Mr Lb MgA w МkB AKRON EIF2 HSA GMr Tra MgB Lь LULLLLLLLLLLLL FDA Mr MgA MkA TrA ...
#58.
Translation Initiation: Reconstituted Systems and ...
eIF2,. eIF5,. and. eIF5B. 5.1. Buffers Buffer D 20 mM Tris, pH 7.5, 2 mM DTT, ... 2 mM DTT, 0.1 mM EDTA, 5% glycerol Most native eIF2 and smaller amounts of ...
#59.
The eIF2 Complex and eIF2α | SpringerLink
eIF2 is a three-subunit complex that forms the core of the eIF/GTP/Met-tRNAiternary complex, which is essential for translation initiation.
#61.
Regulation of translation in infected cells - FLAX library
We have eIF2 bound to a molecule of GDP. And this is not useful for making a new ternary complex. You have to have GTP present, so it has to be recycled off. So ...
#62.
eIF2B and the Integrated Stress Response: A Structural and ...
EIF2 is a guanosine triphosphatase that becomes activated by eIF2B, a two-fold sym. and heterodecameric complex that functions as eIF2's ...
#64.
Filament formation by the translation factor eIF2B regulates ...
eIF2 mediates the first step of translation initiation, where it binds the initiator methionyl-tRNA and forms a ternary complex that is involved in recognizing ...
#65.
Organelles—Advances in Research and Application: 2012 Edition
17 alpha-AED induced eukaryotic translational initiation factor 2 alpha (eIF2 alpha) phosphorylation in glioma cells which correlated with ...
#66.
What is eIF2alpha? - SidmartinBio
Eukaryotic initiation factor 2 (eIF2) regulates global protein translation by binding to Met-tRNA and the 40S ribosome to form the ...
#67.
EIF2 - Taarbæk IF 06.10.2012 2 - 2 - YouTube
#68.
Molecular Kinesis in Cellular Function and Plasticity
GTP hydrolysis by eIF2 is activated by eIF5, a 49-kDa polypeptide that interacts specifically with eIF2 and eIF3 (9, 10). Recent data suggest that eIF5 is a ...
#70.
Cellular Signal Processing: An Introduction to the Molecular ...
eIF2. kinases. are. stress-sensitive. repressors ... As a result, the interaction of eIF2 with its GEF eIF2B is interrupted and translation is blocked at ...
Class Members General role eIF1 eIF1, eIF1A Multiple effects in enhancing initiation of complex formation and AUG selection eIF2 eIF2, eIF2B* GTP‐dependent ...
... that alter epigenetic status, eIF2 kinases that control translation initiation, and acetylases that operate outside of the nucleus.
#74.
史明- 哈尔滨工业大学教师个人主页
Transcriptome profiling unveils GAP43 regulates ABC transporters and EIF2 signaling in colorectal cancer cells. BMC Cancer. 2021 Jan 5;21(1):24.
#75.
pkr biology. Phosphorylated eIF2 is an inhibitor of its guanine ...
Phosphorylated eIF2 is an inhibitor of its guanine nucleotide exchange factor, eIF2B. The aim of this project is to identify individual viral adaptive ...
#77.
Duodenal mucosal expression of COVID-19-related genes in ...
... EIF2 pathways) and inflammation (CCR2, CXCL2, and LCN2, but not other inflammation-related pathways eg, IL-2 and IL-6 signaling).
#78.
1 unit left xy QXGU 2) translation - Database Error
These are 1) the 40S ribosomal subunit, to which the eIF1, eIF1A, and eIF3 initiation factors are bound; 2) the eIF2. This method generates a simple machine ...
#79.
chop pathways fever. Introduction ± Neonatal Fever This ...
HCV has been shown to activate IRE1, inhibit XBP1s activity, and block eIF2 phosphorylation (4, 48–50). Rashesandarthritiscanoccur Entry of classical swine ...
#80.
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... which contains eukaryotic initiation factor 2-methionine transfer RNA (eIF2-Met-tRNAi-GTP), the 40S ribosomal subunit, eIF3, and eIF1A, (2) recruitment ...
#81.
myelin patch. Sim. The myelin sheath, a fatty coat surrounding ...
Way is currently concentrating on a vital component of the ISR, a specific protein called eIF2-alpha. Convelo plans to enter clinical trials next year, ...
#82.
LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 ...
#Nsclc#Chromosome#Eif2#Tdp#Lncrnas Lcetrl3#Egfr#Gwas#Akt. Nature.com. Impaired selective renal filtration captured by eGFR/eGFR ratio is ...
eif2 在 EIF2 - Taarbæk IF 06.10.2012 2 - 2 - YouTube 的推薦與評價
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