由 T Adomavicius 著作 · 2019 · 被引用 65 次 — As eIF2B levels are lower than eIF2 in cells, partial phosphorylation is sufficient to attenuate protein synthesis initiation. A range of stress ... ... <看更多>
「eif2 alpha phosphorylation」的推薦目錄：
eif2 alpha phosphorylation 在 真核起始因子2 - 維基百科，自由的百科全書 的相關結果
eIF2 是一個異源三聚體，由α、β、γ三個亞基組成。三個亞基的胺基酸序列高度保守（人與酵母對應亞基之間的序列等同性高達47 – 72 %） ... ... <看更多>
eif2 alpha phosphorylation 在 The role of host eIF2α in viral infection | Virology Journal 的相關結果
Once eIF2α is phosphorylated, the eIF2 affinity for eIF2B is increased ... This kinase phosphorylates the eIF2 α subunit and reduces protein ... ... <看更多>
eif2 alpha phosphorylation 在 Evidence That Phosphorylation of the α-Subunit of eIF2 Does ... 的相關結果
A mechanism based on reversible phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2α) has been confirmed as an important ... ... <看更多>
eif2 alpha phosphorylation 在 eIF2-alpha (human) - PhosphoSite 的相關結果
eIF2 -alpha Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal ... ... <看更多>
eif2 alpha phosphorylation 在 Importance of eIF2α Phosphorylation and Stress Granule ... 的相關結果
Phospho -eIF2α restricts the activity of the guanine nuclear exchange factor eIF2B, which is responsible for the formation of the GTP–eIF2–tRNAi Met ternary ... ... <看更多>
eif2 alpha phosphorylation 在 Phospho-eIF2α (Ser51) Antibody#9721 - Cell Signaling ... 的相關結果
Phosphorylation of the eukaryotic initiation factor 2 (eIF2) α subunit is a well-documented mechanism to downregulate protein synthesis under a variety of ... ... <看更多>
eif2 alpha phosphorylation 在 ER Stress-Induced eIF2-alpha Phosphorylation Underlies ... 的相關結果
ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin. Julia Leitman,. ... <看更多>
eif2 alpha phosphorylation 在 Human Phospho-eIF2 alpha (S52) Antibody MAB39971 - R&D ... 的相關結果
Phosphorylation of eIF2 alpha on Ser 52 increases the affinity of eIF2 alpha for eIF2B, a guanine nucleotide exchange factor needed for the ... ... <看更多>
eif2 alpha phosphorylation 在 Phospho-eIF2 alpha subunit 1 (Ser52) Antibody (BS-4842R) 的相關結果
Bioss Anti-Phospho-eIF2 alpha subunit 1 (Ser52) Polyclonal, Catalog # BS-4842R. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), ... ... <看更多>
eif2 alpha phosphorylation 在 Eukaryotic Initiation Factor 2 Phosphorylation and ... 的相關結果
Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide ... ... <看更多>
eif2 alpha phosphorylation 在 Regulation of Protein Synthesis by Hypoxia via Activation of ... 的相關結果
The exchange is mediated by eIF2B, and this reaction is inhibited when one of the three subunits of eIF2, eIF2α, becomes phosphorylated at ... ... <看更多>
eif2 alpha phosphorylation 在 eIF2 alpha phosphorylation alleviates UVA-induced HO-1 ... 的相關結果
UVA causes endoplasmic reticulum stress, hence phosphorylates the α subunit of eIF2. Meanwhile, UVA also induces expression of haem ... ... <看更多>
eif2 alpha phosphorylation 在 CASPASE-DEPENDENT PKR ACTIVATION AND eIF2-α ... 的相關結果
The protein kinase PKR is a major player in the cellular antiviral response, acting mainly by phosphorylation of the α-subunit of the eukaryotic translation ... ... <看更多>
eif2 alpha phosphorylation 在 Phospho-EIF2 alpha (Ser 52) cellular HTRF kit | Cisbio 的相關結果
The phospho-EIF2 alpha assay is designed for the cell-based quantitative detection of Ser52 phosphorylation on EIF2 alpha. In NASH, lipid accumulation in ... ... <看更多>
eif2 alpha phosphorylation 在 6I3M: eIF2B:eIF2 complex, phosphorylated on ... - RCSB PDB 的相關結果
Phosphorylation of the translation initiation factor eIF2 alpha at a conserved serine residue mediates translational control at the ISR core ... ... <看更多>
eif2 alpha phosphorylation 在 Circadian clock control of eIF2α phosphorylation is necessary ... 的相關結果
We demonstrate that rhythmic accumulation of phosphorylated eIF2α requires ... control is phosphorylation of the α-subunit of eIF2 (25, 28). ... <看更多>
eif2 alpha phosphorylation 在 Regulation of Guanine Nucleotide Exchange through ... 的相關結果
由 SR Kimball 著作 · 1998 · 被引用 123 次 — Phosphorylation of eIF2α converts eIF2 from a substrate into a competitive ... either unphosphorylated eIF2 or eIF2 phosphorylated on Ser 51 of the α-subunit ... ... <看更多>
eif2 alpha phosphorylation 在 a strategy to overcome the antiviral effect of protein kinase PKR 的相關結果
Phosphorylation of eukaryotic initiation factor 2α (eIF2α) blocks ... eIF2 is an oligomer composed of three subunits (α, β, γ) that interact with GTP and ... ... <看更多>
eif2 alpha phosphorylation 在 The integrated stress response - EMBO Press 的相關結果
all the stress stimuli that activate ISR is phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2a) on ... ... <看更多>
eif2 alpha phosphorylation 在 Phosphorylation of translation initiation factor eIF2α at Ser51 ... 的相關結果
Once activated, eIF2α kinases specifically phosphorylate eIF2α at serine51 (Ser51). Phosphorylated eIF2α inhibits the function of a guanine ... ... <看更多>
eif2 alpha phosphorylation 在 EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha ... 的相關結果
The C-terminal domain of PERK (EIF2AK3) has kinase activity when PERK homodimerizes. PERK kinase specifically phosphorylates Ser52 of eIF2-alpha, ... ... <看更多>
eif2 alpha phosphorylation 在 Anti-phospho-eIF2 α (pSer 51 ) antibody produced in rabbit 的相關結果
Anti-phospho-eIF2 α(pSer51) antibody has been used in western blotting and immunohistochemistry. Biochem/physiol Actions. EIF2S1 (eukaryotic translation ... ... <看更多>
eif2 alpha phosphorylation 在 Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 ... 的相關結果
Phosphorylation of serine 51 residue on the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) inhibits the guanine nucleotide exchange (GNE) ... ... <看更多>
eif2 alpha phosphorylation 在 QuickGO::Term GO:0036492 的相關結果
eiF2alpha phosphorylation in response to endoplasmic reticulum stress · Synonyms · Ancestor Chart · Child Terms · Annotation Blacklist · Co-occurring Terms · Change ... ... <看更多>
eif2 alpha phosphorylation 在 The structural basis of translational control by eIF2 ... 的相關結果
Phosphorylation of the translation initiation factor eIF2 alpha at a conserved serine residue mediates translational control at the ISR. ... <看更多>
eif2 alpha phosphorylation 在 Mitochondrial dysfunction induces dendritic loss via eIF2α ... 的相關結果
We also observed that eIF2α phosphorylation mediates dendritic loss when ... eIF2α is the α subunit of eIF2, and its active form promotes general protein ... ... <看更多>
eif2 alpha phosphorylation 在 Stress-induced inhibition of translation independently of eIF2α ... 的相關結果
Phosphorylation of eIF2α on residue S52 (S51 in mammalian cells) leads ... Initiation factor eIF2 alpha phosphorylation in stress responses ... ... <看更多>
eif2 alpha phosphorylation 在 Adaptive Basal Phosphorylation of eIF2α Is Responsible for ... 的相關結果
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development ... ... <看更多>
eif2 alpha phosphorylation 在 Eukaryotic initiation factor 2α phosphorylation mediates fetal ... 的相關結果
... upstream eIF2α kinases are activated and phosphorylate eIF2 on the α-subunit at Ser51. Phosphorylated eIF2α (p-eIF2α) reduces global protein translation ... ... <看更多>
eif2 alpha phosphorylation 在 eIF2 Phosphorylation by GCN2 Is Induced in the Presence of ... 的相關結果
by eukaryotic initiation factor 2 subunit α (eIF2α) phosphorylation. This phosphorylation inhibits the conversion of eIF2-GDP to eIF2-GTP, ... ... <看更多>
eif2 alpha phosphorylation 在 Rabbit eIF2alpha (Phospho-Ser51) Polyclonal Antibody 的相關結果
Phospho -eIF2 alpha (Ser51) Antibody detects endogenous levels of eIF2 alpha only when phosphorylated at Ser52, which site historically referenced as Ser51. ... <看更多>
eif2 alpha phosphorylation 在 EIF2S1 - Eukaryotic translation initiation factor 2 subunit 1 的相關結果
"An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation." Lee Y.Y., Cevallos R.C., Jan E. ... <看更多>
eif2 alpha phosphorylation 在 Protein Stability Buffers the Cost of Translation Attenuation ... 的相關結果
Translation attenuation following eIF2a phosphorylation is ... Phosphorylation of initiation factor 2 alpha by protein kinase GCN2. ... <看更多>
eif2 alpha phosphorylation 在 a regulator of global translation in response to cellular stress 的相關結果
eIF2 is a heterotrimer consisting of alpha, beta, and gamma subunits. The 36kDA eIF2α subunit serves a key regulatory role. Phosphorylation ... ... <看更多>
eif2 alpha phosphorylation 在 Fail-safe control of translation initiation by dissociation ... - eLife 的相關結果
Phosphorylation of eIF2α controls translation initiation by restricting the levels of active eIF2-GTP/Met-tRNAi ternary complexes (TC). ... <看更多>
eif2 alpha phosphorylation 在 Control of oncogenesis by eIF2α phosphorylation - Future ... 的相關結果
Eukaryotic cells respond to various forms of stress by inducing the phosphorylation of the α-subunit of eIF2 at S51, a modification that ... ... <看更多>
eif2 alpha phosphorylation 在 Roles of the Translation Initiation Factor eIF2α ... - J-Stage 的相關結果
It is often assumed that α-subunit phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) complex is just a mechanism to control protein ... ... <看更多>
eif2 alpha phosphorylation 在 eIF2alpha Phosphorylation in Synaptic Plasticity, Memory, and ... 的相關結果
The studies in this competing renewal are focused on the phosphorylation of the translation initiation factor eIF2 and the protein kinases that phosphorylate it ... ... <看更多>
eif2 alpha phosphorylation 在 regulation of endoplasmic reticulum stress-induced eIF2 alpha ... 的相關結果
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress. Parent Terms: ... ... <看更多>
eif2 alpha phosphorylation 在 The Structural Basis of Translational Control by eIF2 ... - bioRxiv 的相關結果
Phosphorylation of the translation initiation factor eIF2 alpha at a conserved serine residue mediates translational control at the ISR core ... ... <看更多>
eif2 alpha phosphorylation 在 Phosphorylation of eIF2α mitigates endoplasmic reticulum ... 的相關結果
eIF2 is a 126kDa protein composed of α, β and γ subunits that are essential for mRNA translation and subsequent protein synthesis [21]. The phosphorylated eIF2α ... ... <看更多>
eif2 alpha phosphorylation 在 Phosphorylation of Eukaryotic Initiation Factor 2 Alpha ... 的相關結果
in protein synthesis is the phosphorylation of the alpha subunit of the eukaryotic translation initiation factor-2 (eIF2). eIF2 is a multimeric protein ... ... <看更多>
eif2 alpha phosphorylation 在 Translation - Regulation of EIF2 activity Pathway Map - Bio-Rad 的相關結果
Key pathways of eIF2 activity regulation are phosphorylation of eIF2S1 and ... There are Eukaryotic translation initiation factor 2-alpha kinase 1, 2, ... ... <看更多>
eif2 alpha phosphorylation 在 eIF2α磷酸化减轻了小鼠表皮细胞中UVA诱导的HO-1表达。 的相關結果
eIF2 alpha phosphorylation alleviates UVA-induced HO-1 expression in mouse ... endoplasmic reticulum stress, hence phosphorylates the α subunit of eIF2. ... <看更多>
eif2 alpha phosphorylation 在 cells - Archive ouverte HAL 的相關結果
stimulates perk-dependent eIF2[alpha] phosphorylation and regulates protein ... DEPENDENT eIF2a PHOSPHORYLATION AND REGULATES PROTEIN. ... <看更多>
eif2 alpha phosphorylation 在 eIF2 alpha (phospho-Ser51) antibody - Biorbyt 的相關結果
The antiserum was produced against synthesized phosphopeptide derived from human eIF2 alpha around the phosphorylation site of serine 51 (E -L-S P -R-R). Target ... ... <看更多>
eif2 alpha phosphorylation 在 eIF2-alpha-P | Phosphorylated Eukaryotic translation initiation ... 的相關結果
Anti- eIF2-alpha-P | Phosphorylated Eukaryotic translation initiation factor 2 subunit alpha. ... <看更多>
eif2 alpha phosphorylation 在 Phosphorylation of eif2 alpha on threonine 169 is not required ... 的相關結果
Phosphorylation of eif2 alpha on threonine 169 is not required for trypanosoma brucei cell cycle arrest during differentiation ... ... <看更多>
eif2 alpha phosphorylation 在 Phosphorylation of the α subunit of translation initiation factor ... 的相關結果
eIF2 participates in translation initiation as a ternary complex, eIF2–GTP–Met-tRNAi Met (initiator methionyl-tRNA), which delivers the initiator tRNA to the 40 ... ... <看更多>
eif2 alpha phosphorylation 在 eukaryotic translation initiation factor 2, subunit 1; eif2s1 - OMIM 的相關結果
The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987). ... <看更多>
eif2 alpha phosphorylation 在 eIF-2-alpha kinase GCN2 | DrugBank Online 的相關結果
2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 4 ... protein phosphorylation / regulation of eIF2 alpha phosphorylation by amino acid ... ... <看更多>
eif2 alpha phosphorylation 在 eIF2 α Inhibitors | SCBT 的相關結果
In mammalian cells, translation is controlled at the level of polypeptide chain initiation by initiation factors. Biochemicals that inhibit eIF2 alpha have ... ... <看更多>
eif2 alpha phosphorylation 在 Phosphorylation of eIF2 alpha in Sf9 cells: a stress, survival ... 的相關結果
While caspase activation is a cause and consequence of eIF2alpha phosphorylation, PKC activation that follows casp enzyme activation further ... ... <看更多>
eif2 alpha phosphorylation 在 AT5G05470(EIF2 ALPHA) - TAIR 的相關結果
ATEIF2-A2, EIF2 ALPHA, EIF2-A2, EUKARYOTIC TRANSLATION INITIATION FACTOR 2 ... Encodes an eIF2alpha homolog that can be phosphorylated by GCN2 in vitro. ... <看更多>
eif2 alpha phosphorylation 在 Phosphorylation of the α-Subunit of the Eukaryotic ... - DOI 的相關結果
Phosphorylation of eIF2α in mouse embryo fibroblast (MEF) cells subjected to ... phosphorylate the α-subunit of eukaryotic initiation factor-2 (eIF2) (3). ... <看更多>
eif2 alpha phosphorylation 在 The role of CReP in reversing eIF2-alpha phosphorylation ... 的相關結果
During the unfolded protein response, reversible phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2- α) occurs. This ... ... <看更多>
eif2 alpha phosphorylation 在 Polyclonal Antibody to eIF2 Alpha (phospho-Ser49) - Abeomics 的相關結果
Polyclonal Antibody to eIF2 Alpha (phospho-Ser49) ... Alternative Name : Eukaryotic translation initiation factor 2 subunit alpha. Format : Purified. ... <看更多>
eif2 alpha phosphorylation 在 EIF2S1 Gene - GeneCards | IF2A Protein | IF2A Antibody 的相關結果
The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]). ... <看更多>
eif2 alpha phosphorylation 在 eIF2 α polyclonal antibody - ADI-KAP-CP130 - Enzo Life ... 的相關結果
Phosphorylated eIF-2α inhibits cell growth and induces apoptosis. Phosphorylation of eIF-2α occurs under a variety of conditions including viral infection, ... ... <看更多>
eif2 alpha phosphorylation 在 Thesis | Control of eIF2 alpha kinases by tyrosine ... 的相關結果
Recent research has established the existence of a protein kinase family in mammalian cells, whose members phosphorylate the alpha (alpha) subunit of the ... ... <看更多>
eif2 alpha phosphorylation 在 eIF2 alpha (phospho Ser51) - Nordic Biosite 的相關結果
Description, eIF2 alpha (phospho Ser51) antibody. Supplier, GeneTex. Entrez Gene ID, 1965. Format, Liquid. Gene Symbol, EIF2S1. ... <看更多>
eif2 alpha phosphorylation 在 eIF2α Phosphorylation-Dependent Translation in CA1 ... 的相關結果
Reversible phosphorylation of the α subunit of eIF2 on Ser51 is one of the best characterized rate-limiting steps at the translational ... ... <看更多>
eif2 alpha phosphorylation 在 Dmel\eIF2α - FlyBase Gene Report 的相關結果
eukaryotic translation initiation factor 2 subunit alpha (eIF2α) encodes one of three subunits of the eIF-2 ... eIF-2alpha, eIF-2α, eIF2a, eIF-2, l(1)19-153. ... <看更多>
eif2 alpha phosphorylation 在 Circadian Clock Regulation of Translation Initiation in ... 的相關結果
I discovered that phosphorylation of eIF2(alpha), a conserved translation initiation factor, is clock-controlled, peaking during the ... ... <看更多>
eif2 alpha phosphorylation 在 Regulation of translation in infected cells - FLAX library 的相關結果
The phosphorylation of eIF2 inhibits host translation. It also stimulates apoptosis, and this is basically shutting down the cell so the virus can't replicate. ... <看更多>
eif2 alpha phosphorylation 在 PKR: dsRNA and stress sensor - ViralZone 的相關結果
eIF2 alpha phosphorylation results in arrest of translation of both cellular and viral mRNAs. Viruses have evolved different strategies to avoid complete arrest ... ... <看更多>
eif2 alpha phosphorylation 在 Protein Phosphorylation - BioLegend 的相關結果
Learn more about each protein and view the important phosphorylation sites. Also find upstream kinases and phosphatases that interact with the protein. AKT, α- ... ... <看更多>
eif2 alpha phosphorylation 在 What is eIF2alpha? - SidmartinBio 的相關結果
? Phospho-eIF2alpha (Ser51) Antibody detects endogenous eIF2alpha only when phosphorylated at Ser51. The ... ... <看更多>
eif2 alpha phosphorylation 在 Initiation factor eIF2 alpha phosphorylation in stress ... - PubMed 的相關結果
The alpha subunit of polypeptide chain initiation factor eIF2 can be phosphorylated by a number of related protein kinases which are activated in response ... ... <看更多>