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在journal of gastroenterology這個產品中，有13篇Facebook貼文，粉絲數超過3萬的網紅新思惟國際，也在其Facebook貼文中提到， 「我的統合分析冒險之旅是極端幸運的。因為在《統合分析工作坊》課後，我立刻就想到了主題，不僅簡單、和自己的專業方向相符、還沒有人寫過！」（義大醫院 健診部 葉人豪 醫師） ⠀ 【🎉 #葉人豪醫師 參與團隊關於 simethicone 對大腸鏡檢查效益之統合分析，獲 Journal of Gastroe...
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journal of gastroenterology 在 新思惟國際 Facebook 的最佳解答

新思惟國際 By 新思惟國際

2021-08-27 07:00:52 有 33 人按讚
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「我的統合分析冒險之旅是極端幸運的。因為在《統合分析工作坊》課後，我立刻就想到了主題，不僅簡單、和自己的專業方向相符、還沒有人寫過！」（義大醫院 健診部 葉人豪 醫師）
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【🎉 #葉人豪醫師 參與團隊關於 simethicone 對大腸鏡檢查效益之統合分析，獲 Journal of Gastroenterology and Hepatology 刊登！】
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👁‍🗨 統合分析的價值與機會
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相較於需要大量資源的隨機試驗和前瞻研究、或需要時間累積和適當環境的回溯性研究，＃統合分析 的成本相對較低。此外設計良好、結論重要的統合分析，其影響力並不下於一般的原創性研究，甚至猶有過之。因此對於年輕研究者而言，其實是一個理想的起步方式。
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課後很快想到題目，所以能趁記憶猶新時把上課內容再次演練。反覆做了幾次後，很多東西自然而然變得熟悉，進而行有餘力去了解更多未知的細節，直到成功寫出文章。除此以外，更多的功勞仍然要歸給新思惟的統合分析課程。
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👁‍🗨 課程概念清晰、框架嚴謹、具可操作性
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如果要用一句話評價新思惟課程，我的答案是「能夠現學現賣的好東西」。社會人士的自主進修學習，應該要以在工作或生活能用得上為目標。新思惟的工作坊有大量的課前與課後問答，這等於是預習和複習，也讓初學者知道可能會遇到什麼問題、又要如何解決。
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課堂上除了講解統合分析的資料搜尋方式、架構、意義，最特別的是核心的製圖以限時比賽的形式，讓大家親手做出圖表來建立信心、並在頒獎前的講解中知道製圖時常犯的錯誤與陷阱。真是寓教於樂，一手棒子、一手胡蘿蔔的最佳範例（誤）！
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（葉醫師在快訊心得中，更是大方地分享「給 ＃統合分析入門者 的四個建議」，歡迎至貼文中觀看完整心得！）
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🎯 克服經費與資源稀少的困境，帶您踏入統合分析的領域！
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☑ 統合分析研究規劃技巧
☑ 正確拆解論文架構
☑ 必學的重要專有名詞
☑ 互動實作：完成一套 Meta-analysis 圖表
☑ 以發表為導向的搜尋文獻
☑ Meta-analysis 圖表優化重點
☑ 給初學者的起步建議
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🔸 【全新梯次】11/7（日）統合分析工作坊
➠ https://meta-analysis.innovarad.tw/event/
現在投資自己，將來 PubMed 上有你。
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👨‍🏫 堅強講者陣容
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＃張凱閔，知名復健醫學與超音波學者，台大流病與預防醫學博士，SCI 論文超過 190 篇，並有 25 篇以上為 meta-analysis，探討臨床常見議題。
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＃曾秉濤，專業精神科醫師，擅長從臨床工作找到發表議題，並組成研究團隊，SCI 論文超過 85 篇，並有 70 篇以上為 meta-analysis。
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＃蔡依橙，專業課程開發與整合者，能迅速理解學門架構，並以初學者能理解的方式，建構學習流程。生涯被 SCI 期刊接受的圖表，已超過 500 張，熟悉學術審閱過程與要求。

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實用型互動工作坊 高品質大型研討會 http://www.innovarad.tw/
實用型互動工作坊 高品質大型研討會 (用「心」的新思「惟」)
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journal of gastroenterology 在 可貓all cat Facebook 的最佳貼文

可貓all cat By 可貓all cat

2021-05-30 04:43:48 有 0 人按讚
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疫情嚴重，注意健康，加油

2019-2020相關資料文獻整理
＃新型冠狀病毒和黑種草油的科學研究
2019-nCoV & Nigella Sativa Science
Researches
＃林博士聲明: 2020.01.28
1.本文為本人整理編寫的原創文獻醫學文稿，重要內容均注明原文出處(或網路連結)若有疏漏，敬請指正。

（一）＃抗病毒作用-正義單鏈RNA病毒
Antiviral effect-positive and single stranded RNA virus
- 2019新型冠狀病毒(Novelcoronavirus)，世界衛生組織命名縮寫為2019-nCoV、武漢肺炎(Wuhanpneumonia)等。2019新型冠狀病毒與2003年4月在亞洲爆發SARS，SARS-CoV都是正義單鏈RNA病毒(positivesinglestrandedRNAvirus)，這類病毒還包括人類的C型肝炎病毒(HepacivirusC)。

黑種草油(子)迄今並無抗冠狀病毒的研究。但臨床研究顯示黑種草油可以抗C型肝炎病毒(30名C肝病患)，降低體內病毒載量。
埃及30名患有C型肝炎病毒(HCV)感染患者，未經甲型干擾素(α-Interferon)治療，每天餐後食用黑種草油，每日3次，連續服用3個月後，可顯著改善HCV病毒載量(380808.7±610937vs147028.2±475225.6,P=0.001)和提高體內總抗氧化能力TAC(1.35±0.5vs1.612±0.56, P=0.001)，與下列實驗室參數得到改善：總氮蛋白、白蛋白、紅血球細胞數、血小板計數和下肢水腫等臨床狀況指數。

1.Barakat, EmanMahmoud Fathy, Lamia Mohamed El Wakeel, and RadwaSamir Hagag. "Effects of Nigella sativa on outcome of hepatitis C in Egypt." World journal of gastroenterology: WJG 19.16 (2013): 2529.
2.Oyero, OlufunmilayoG., et al. "Selective inhibition of hepatitis c virus replication by Alpha-zam, a Nigella sativa seed formulation." African journal of traditional, complementary and alternative medicines 13.6 (2016): 144-148.

(二) ＃免疫調節-提高巨噬細胞和樹突狀細胞作用.
*Immunomodulatory effects
- 研究顯示:黑種草油或其活性成分百里醌(TQ，Thymoquinone)可以調節免疫力(Th1和Th2)，提高巨噬細胞(macrophage)和樹突狀細胞(dendriti)作用，顯示出有效的抗發炎作用。

黑種草油可增加吞噬活性(吞噬率56.83±6.37％)和吞噬指數(5.18±0.39)，巨噬細胞分泌IL-12(最高水平在66.33±2.11μM)和TLR4的表達。數據通過單因子變異數分析(One-wayANOVA)進行統計學檢驗，顯著性為95％。

1.Akrom, Akrom, and MustofaMustofa. "Black cumin seed oil increases phagocytic activity and secretion of IL-12 by macrophages." Biomedical Research 28.12 (2017): 5241-5246.
2.Finlay, Trisha M., et al. "Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo." Glycoconjugate journal 27.6 (2010): 583-600.
3.Salem, Mohamed Labib. "Immunomodulatory and therapeutic properties of the Nigella sativa L. seed." International immunopharmacology 5.13-14 (2005): 1749-1770.

(三) ＃善肺部發炎症狀和損傷
Improve lung inflammation and injury
- 動物研究顯示:黑種草和其提取物或百里醌(TQ)對氣管反應和肺部炎症有預防作用，黑種草油可顯著降低因高氧吸入引起的肺損傷。
●黑種草的百里醌(TQ，thymoquinone)治療致敏組動物，可顯著善其肺部病理變化，降低其IL-4水平(p<0.05至p<0.001)，增加其IFN-γ水平(p<0.001)。
●黑種草治療可抑制炎症性肺反應，顯著降低（p<0.05）支氣管周炎性細胞浸潤、肺泡中隔浸潤、肺泡水腫 肺泡滲出液、肺泡巨噬細胞和間質纖維化，肉芽腫和壞死形成。
●在組織病理學和免疫化學評估中，高氧+ 黑種草組的肺損傷嚴重程度明顯降低（P <.05)，GSH-Px(穀胱甘肽氧化物酶)和SOD(超氧化物歧化酶)水平得到顯著保留MDA(血清脂質過氧化物)和MPO(骨髓過氧化酶)水平顯著低（P <.05）。

1.Boskabady,MohammadHossein,etal."TheeffectofNigellasativaextractontrachealresponsivenessandlunginflammationinovalbumin-sensitizedguineapigs."Clinics66.5(2011):879-887.
2.Keyhanmanesh,Rana,etal."Effectofthymoquinoneonthelungpathologyandcytokinelevelsofovalbumin-sensitizedguineapigs."Pharmacologicalreports62.5(2010):910-916.
3.Kanter,Mehmet."EffectsofNigellasativaseedextractonamelioratinglungtissuedamageinratsafterexperimentalpulmonaryaspirations."Actahistochemica111.5(2009):393-403.
4.Tayman,Cuneyt,etal."ProtectiveeffectsofNigellasativaoilinhyperoxia-inducedlunginjury."ArchivosdeBronconeumología(EnglishEdition)49.1(2013):15-21.

(四) ＃解呼吸道發炎症狀
Relief the symptoms of respiratory tract infection
- 多篇人體臨床研究:黑種草油可顯著緩解咽喉炎或扁桃腺炎的咽喉腫痛，補充黑種草油可改善哮喘和肺功能。黑種草的精油成分可抑制氣管收縮和增加黏膜纖毛的清除率。
●186位急性咽喉炎測試者，每天3次連續7天服用黑種草油和珠草萃取物，可完全緩解他們的咽喉腫痛，減少對止痛藥的需要。
●抗效喘和擴張氣管
80名哮喘患者的隨機，雙盲，安慰劑對照試驗，每天食用黑種草油兩次，連續4週，NSO組的平均哮喘控制測試得分顯著提高了21.1(標準差= 2.6)和19.6(標準差= 3.7)(p = 0.044)，血液中的嗜酸性粒細胞減少了-50 (-155至-1)對15（-60至87）個細胞/μL(p = 0.013)。
29例哮喘成年患者隨機分為對照組和研究組，研究組給予每天口服黑種草提取
物，研究3個月後顯著改善哮喘症狀的頻率/週，胸部喘息和肺功能測試(PFTs）
值顯著改善(P <0.05到P <0.001)，與對照組相比有顯著差異(P <0.01到P <0.001)。
在15例哮喘患者，黑種草萃取物對哮喘的氣道(airways)具有相對強效的抗喘效果（支氣管擴張）。

●天然氣管擴張劑，抑制氣管收縮和增加黏膜纖毛的清除2010年歐洲藥用植物和天然產品研究雜誌《Planta Medica》研究：黑種草的精油活性成分-百里醌(TQ) 、黑種草酮(Nigellone)是優於哮喘的吸入性氣管擴張藥fluticasone(屬類固醇類)，賦予哮喘和過敏症患者帶來希望。
2008年歐洲藥用植物和天然產品研究雜誌《Planta Medica》研究表明:黑種草油的精油成分黑種草酮(Nigellone)和百里醌(TQ)可用於治療不同的呼吸系統疾病，可緩解氣管的痙攣和增加黏膜纖毛的清除率。

1.Dirjomuljono, M., et al. "Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruriextract." International journal of clinical pharmacology and therapeutics 46.6 (2008): 295-306.
2.Koshak, Abdulrahman, et al. "Nigella sativa supplementation improves asthma control and biomarkers: A randomized, double‐blind, placebo‐controlled trial." PhytotherapyResearch 31.3 (2017): 403-409.
3.Boskabady, Mohammad Hossein, et al. "The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients." Fundamental & clinical pharmacology 21.5 (2007): 559-566.
4.Boskabady, M. H., N. Mohsenpoor, and L. Takaloo. "Antiasthmaticeffect of Nigella sativa in airways of asthmatic patients." Phytomedicine 17.10 (2010): 707-713.
5.Keyhanmanesh, Rana, et al. "The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs." Planta medica 76.03 (2010): 218-222.
6.Wienkötter, N., et al. "The effect of nigelloneand thymoquinone on inhibiting trachea contraction and mucociliaryclearance." Planta medica 74.02 (2008): 105-108.

#薑黃文獻研究
●#薑黃的薑黃素抑制所有C型肝炎病毒基因型進入人肝細胞
Colpitts, Che C., et al. "Turmeric curcumin inhibits entry of all hepatitis C virusgenotypes into human liver cells." Gut 63.7 (2014): 1137-1149
●#薑黃素在病毒性急性呼吸窘迫綜合症的老鼠模中，調節發炎症反應並抑制隨後的纖維化
Avasarala, Sreedevi, et al. "Curcumin modulates the inflammatory response and inhibits subsequent fibrosis in a mouse model of viral-induced acute respiratory distress syndrome." PloSone 8.2 (2013).
●#薑黃素通過減輕肺損傷和調節巨噬細胞細胞因子產生來減輕嚴重的流感性肺炎
Han, Shuguang, et al. "Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production." Clinical and Experimental. Pharmacology and Physiology 45.1 (2018): 84-93.

#蜂蜜文獻研究
●2014年一項基於前瞻性隊列研究:以蜂蜜做保守療，35％的慢性C型肝炎病毒患者可持續清除C肝炎病毒
KOTB, MAGD A., and AHMED K. ABDALLA. "Sustained Hepatitis C Virus Clearance was Achieved by Honey Based Conservative Management in 35% of Chronic Hepatitis C Virus Patients: A Prospective Cohort Study." Interferon 8: 10.
●蜂蜜與健康：近期臨床研究述評-蜂蜜具抗發炎免疫調節活性、減少咳嗽、發燒和減輕哮喘相關症狀
Samarghandian, Saeed, TaherehFarkhondeh, and FariborzSamini. "Honey and health: A review of recent clinical research." Pharmacognosy research 9.2 (2017): 121.)

#食用建議

＃黑種草油5ml + ＃蜂蜜10ml +＃薑黃粉(＃或薑黃素)適量
❗每日2次❗

＃黑種草油、＃蜂蜜和薑黃
都有抗單股RNA病毒、抗發炎、減少肺部發炎症狀，調節免疫力和增加抵抗力的效果，非常適合這個季節做為每日保健的補充劑。

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可貓all cat

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傻大嬸可貓■ 點點滴滴動物園 ~遇見，習慣，愛上，最後變成貓~ ~有貓，故我在 ★各國好物直播
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journal of gastroenterology 在 新思惟國際 Facebook 的最佳貼文

新思惟國際 By 新思惟國際

2021-02-18 18:00:01 有 358 人按讚
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「#發表文章 是我最重要的動機，由於自己一邊工作一邊讀書，有文章發表才有辦法取得畢業之門的鑰匙，我知道不用收案的 #統合分析，也能夠在知識上提供高等級的證據，同時亦是最快取得畢業鑰匙的方式。」（🗣 成大醫院 蘇睿寧 護理長）
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#課前提問的回覆 根本有洋蔥，講師針對我們這些有知識或是沒常識的問題，逐一回答、排版成冊，甚至針對問題做更多的延伸，這部分完全客製化。還好我在課前不要臉地提問了許多問題，能夠得到高手的解答，又是一次賺到。
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#授課過程 十分緊湊，無論是蔡校長、曾秉濤醫師或是張凱閔醫師，都是知無不言、言無不盡，針對我們新手在發表論文時最害怕、最容易深陷的地方，提供具體的說明與建議，還有許多「小撇步」，盡可能地協助我們這些新手上路。
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#每一堂課後QA，只要舉手發問，必能針對自己的疑惑，得到最直接的解答。
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而自己摸索的 #互動實作 課程，讓我印象非常深刻，依照自己對書上指示的理解前進，遇到困難時專家就在身邊，身歷其境的學習，果然很容易上手，即便犯錯，也能記得解決之道。完成後也更具信心，自己是真的會了！
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#課後提問 的部分，我會好好把握賺到的機會！感謝新思惟的課程規劃，從開始到結束完全沒有冷場。回家後我也把專屬的馬克杯，放在最顯眼的位置，不斷的提醒自己，趕快寫論文賺回學費 XD。
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最後，我想說：「參加新思惟，絕對不後悔！」
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－
【🔥 以發表 SCI 為學習目的，一天學會統合分析的技能！】
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✓ Meta-analysis 研究規劃技巧：以指定論文為例
✓ 拆解論文架構：照這樣做，最容易。
✓ 那些重要的專有名詞：Meta-analysis 重要數值
✓ 互動實作時間：完成一套 Meta-analysis 圖表
✓ 我是怎麼搜尋文獻的：以發表為導向
✓ Meta-analysis 圖表優化重點
✓ 給初學者的起步建議：減少卡關，邁向成功。
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🚩 無經費、無資源者的起步首選！
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實用型互動工作坊 高品質大型研討會 (用「心」的新思「惟」)
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journal of gastroenterology 在 [email protected] Youtube 的最讚貼文

FindDocTV@FindDoc.com By [email protected]

2020-12-30 15:00:07 有 48,002 人看過 有 0 人喜歡
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益生菌 － 黃世豪腸胃及肝臟科專科醫生＠FindDoc.com

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（一）食物補充益生菌可行嗎？ 00:06

（二）益生菌是什麼？ 00:42

（三）益生菌有什麼功用？ 01:23

（四）醫生如何選擇適合病人的益生菌？ 01:54

(本短片作健康教育之用，並不可取代任何醫療診斷或治療。治療成效因人而異，如有疑問，請向專業醫療人士諮詢。)

參考資料：
1. Lisko, D. J., Johnston, G. P., & Johnston, C. G. (2017). Effects of Dietary Yogurt on the Healthy Human Gastrointestinal (GI) Microbiome. Microorganisms, 5(1), 6. https://doi.org/10.3390/microorganisms5010006
2. Kechagia, M., Basoulis, D., Konstantopoulou, S., Dimitriadi, D., Gyftopoulou, K., Skarmoutsou, N., & Fakiri, E. M. (2013). Health benefits of probiotics: a review. ISRN nutrition, 2013, 481651. https://doi.org/10.5402/2013/481651
3. Hill, D., Sugrue, I., Tobin, C., Hill, C., Stanton, C., & Ross, R. P. (2018). The Lactobacillus casei Group: History and Health Related Applications. Frontiers in microbiology, 9, 2107. https://doi.org/10.3389/fmicb.2018.02107
4. Akatsu H., Iwabuchi N., Xiao J., Matsuyama Z., Kurihara R., Okuda K., et al. (2013). Clinical effects of probiotic Bifidobacterium longum BB536 on immune function and intestinal microbiota in elderly patients receiving enteral tube feeding. J. Parenter Enteral Nutr. 37 631–640. 10.1177/0148607112467819
5. Yang, G., Liu, Z. Q., & Yang, P. C. (2013). Treatment of allergic rhinitis with probiotics: an alternative approach. North American journal of medical sciences, 5(8), 465–468. https://doi.org/10.4103/1947-2714.117299
6. Uronis, J. M., Arthur, J. C., Keku, T., Fodor, A., Carroll, I. M., Cruz, M. L., Appleyard, C. B., & Jobin, C. (2011). Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis. Inflammatory bowel diseases, 17(1), 289–297. https://doi.org/10.1002/ibd.21366
7. Fedorak R. N. (2010). Probiotics in the management of ulcerative colitis. Gastroenterology & hepatology, 6(11), 688–690.
8. Dale, H. F., Rasmussen, S. H., Asiller, Ö. Ö., & Lied, G. A. (2019). Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review. Nutrients, 11(9), 2048. https://doi.org/10.3390/nu11092048
9. Mimura, T., Rizzello, F., Helwig, U., Poggioli, G., Schreiber, S., Talbot, I. C., Nicholls, R. J., Gionchetti, P., Campieri, M., & Kamm, M. A. (2004). Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut, 53(1), 108–114. https://doi.org/10.1136/gut.53.1.108



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香港最全面醫療資訊影片平台，超過200位專科醫生、中醫、物理治療師、營養師等解答你的健康問題。搜尋全港各區醫生資料，即上FindDoc.com! At FindDoc, we aim to increase general public health awareness through our FindDocTV videos. Patients can make doctors’ appointments online using our platform Anytime Anywhere. FindDoc is Free and open to both patients and doctors.
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journal of gastroenterology 在 [email protected] Youtube 的最佳貼文

FindDocTV@FindDoc.com By [email protected]

2019-07-03 15:30:02 有 64,009 人看過 有 0 人喜歡
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益生菌專題 －張世華腸胃肝臟科專科醫生＠FindDoc.com

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（一）街訪：有聽過什麼是益生菌嗎？ 00:00

（二）醫生解話：什麼是益生菌？ 00:32

（三）街訪：什麼食物會含有益生菌？ 01:01

（四）醫生解答：益生菌經過胃酸還能生存嗎？1:15

（五）醫生解答：如何選擇益生菌產品？01:33

（六）醫生解答：日常飲食能補充益生菌嗎？01:48

（七）醫生解答：應該補充多少益生菌？02:18

（八）醫生解答：年紀大壞菌會變多，所以更需要吃益生菌？02:29

（九）醫生解答：益生菌能當補品吃嗎？02:57

(本短片作健康教育之用，並不可取代任何醫療診斷或治療。治療成效因人而異，如有疑問，請向專業醫療人士諮詢。)

參考資料：
1. Magro, F., Gionchetti, P., Eliakim, R., Ardizzone, S., Armuzzi, A., Acosta, M. B., …Raine, T. (2017). ECCO Guideline / Consensus Paper Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis . Part 1 : Definitions , Diagnosis , Extra-intestinal Manifestations , Pregnancy , Cancer Surveillance , Surgery , and Ileo-anal Pouch Disorders, Journal of Crohn’s and Colitis, 11(6), 649–670. doi: 10.1093/ecco-jcc/jjx008
2. Allen, SJ., Martinez, E. G., Gregorio, G. V., & Dans, L. F.(2010) Probiotics for treating acute infectious diarrhoea. Cochrane Database of Systematic Reviews 2010, (11). doi: 10.1002/14651858.CD003048.pub3
3. Didari, T., Mozaffari, S., Nikfar, S., and Abdollahi, M. (2015). Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World journal of gastroenterology, 21(10), 3072–3084. doi:10.3748/wjg.v21.i10.3072


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#93. International Journal of Gastroenterology: Home

Proposing a special issue allows you to become the lead guest editor, and the joined guest editors can then manage the peer review process and compile accepted ...

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Pain practice: the official journal of World Institute of Pain, 17(3), ... The American journal of gastroenterology, 106(9), ...

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#98. 7 Signs of an Unhealthy Gut and 7 Ways to Improve Gut Health

Quigley in his studyTrusted Source on gut bacteria in the Journal of Gastroenterology and Hepatology, having a wide variety of these good bacteria in your gut ...

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#100. Functional Colonic Diseases: Advances in Research and ...

One hundred and twenty-four subjects had no organic gastrointestinal abnormality, IBS, ... Scandinavian Journal of Gastroenterology, 2010;45(5):556-66).