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在ifn gamma這個產品中，有2篇Facebook貼文，粉絲數超過0的網紅，也在其Facebook貼文中提到， 疫苗混打：AZ+BNT的抗體濃度是AZ+AZ的9倍！ 疫苗混打 (Heterologous dosing) 1⃣️ 德國Schmidt et al 的研究 以AZ + AZ，mRNA + mRNA及AZ+ mRNA作為比較。 結果： AZ+BNT的抗體濃度是AZ+AZ的9倍 1. 抗體反應...

ifn gamma 在 Facebook 的最佳解答

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2021-07-31 13:12:57 有 562 人按讚
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疫苗混打：AZ+BNT的抗體濃度是AZ+AZ的9倍！

疫苗混打 (Heterologous dosing)

1⃣️ 德國Schmidt et al 的研究
以AZ + AZ，mRNA + mRNA及AZ+ mRNA作為比較。

結果：
AZ+BNT的抗體濃度是AZ+AZ的9倍

1. 抗體反應：
Spike-specific IgG 使用mRNA的兩組沒有差異
mRNA + mRNA: 4932
AZ + mRNA :3630
但
AZ+AZ為404，

中和抗體濃度：
⭕️ AZ + mRNA (3630)是AZ+ AZ (404) 的9倍

中和抗體產生的抑制效果
AZ + mRNA 及 mRNA + mRNA：100%抑制效果。
AZ + AZ：80%

2. T 細胞免疫：引發CD4 T cells反应
AZ + mRNA 及 mRNA + mRNA 較AZ + AZ高出4倍

AZ + mRNA 及 mRNA + mRNA明顯引發CD4 T cells反應(0.17 , 0.16)

AZ + AZ 明顯較弱，只有0.04。

3. spike-specific IFN-γ-producing CD8 T cells：
AZ + mRNA最優: 0.28% (IQR = 0.54%).
mRNA + mRNA: 0.06% (IQR = 0.19).
AZ + AZ : 0.04% (IQR = 0.08%).

4. 不良反應：混打組比較嚴重。

2⃣️ 另外一篇是Barros-Martins et al的研究

以AZ + AZ vs AZ + BNT作為比較：

✅ anti-spike (S) IgG and IgA：
AZ + AZ 增加2.9倍
AZ + BNT 增加11.5倍

✅ spike-specific memory B cells were significantly increased
AZ + AZ: 增加53.1%
AZ + BNT 增加43.6%

✅ 中和抗體
AZ + AZ and AZ + BNT 兩組都有增加。

✅ AZ + AZ 可增B.1.1.7(Alpha)抗體，但對P.1(Gamma)及 B.1.351(Beta)無作用。
✅ AZ + BNT 對抗Alpha 最強，Gamma and Beta則較弱。
✅ spike-specific CD4+ T cells: 兩組均增加，但AZ + BNT 最強。

詳細內容：
https://reurl.cc/lRbOXY

Ref:
Schmidt, T. et al
https://doi.org/10.1038/s41591-021-01464-w (2021).

Barros-Martins et al.
https://www.nature.com/articles/s41591-021-01449-9

清楚很有美感的解說圖在此
Meagan E et al.
https://www.nature.com/articles/s41591-021-01463-x

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ifn gamma 在 皮膚科 黃昭瑜醫師 Facebook 的最佳貼文

皮膚科 黃昭瑜醫師 By 皮膚科 黃昭瑜醫師

2020-11-22 17:11:22 有 92 人按讚
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年底演講三連發～週末加班gogogo 💪

繼上週的46屆台灣皮膚科醫學會暨第3屆亞洲白斑協會，接下來的兩週，黃昭瑜醫師也即將與各位醫師分享其它白斑新知。透過相互交流討論學習，為病人找尋更好的治療方法～

～*～*～*～*～*～*～*～*～*～*～*～*～*～*
主題 ： What's new in vitiligo ? Updates on the Pathogenesis and Emerging Treatment.
2020年11月29日 (週日) 8:30am - 4:30pm
Skin Science Investment Symposium
地點：張榮發基金會 國際會議中心1001室

簡介：近年來隨著醫學演進，白斑的治病機轉變得越來越清楚。研究發現 IFN gamma 影響CD8 T細胞，造成黑色素細胞的凋亡。 有別於過去，最新的皮膚科聖經Fitzpatrick也將Minipulse steroid 加入急性期的白斑治療指引。JAK/STAT 相關藥物的開發，對於白斑的角色為何？自由基破壞的evidence 為何？ 照光治療的角色在哪裏，要如何照才會最理想？ 色素移植的角色可以被取代嗎？透過這次的演講，幫助大家更了解最新的白斑指引，同時分享黃醫師國外進修所學，以及目前研究的初步成果分析。

～*～*～*～*～*～*～*～*～*～*～*～*～*～*
主題： 雷射術後色素變化的預防與應對
2020年12月6日(週日)9:00 am - 5:00 pm
TAAPS 形體美容外科醫學會
地點：張榮發基金會 國際會議中心801 廳

簡介：醫學美容的盛行，雷射治療黑斑已經是再平常不過的美容治療。然而，雷射術後的色素變化是個惱人的問題。除了常見的反黑，雷射後反白(post-laser leukoderma) 更是一個難纏的副作用，而且更難處理。究竟我們要如何預防雷射後白斑的發生，如何進行完整的評估。 雷射的選擇（皮秒雷射/脈衝光/淨膚雷射etc etc)、參數的調整、與頻率是不是會影響到白斑的發生？透過病例分析與討論，一同找到更好的預防方式，為雷射病人的安全把關。

～*～*～*～*～*～*～*～*～*～*～*～*～*～*

#長庚 #白斑 #新治療 #治病機轉
#雷射後白斑 #黑斑 #雷射 #皮秒 #脈衝光 #淨膚雷射 #雷射反黑 #雷射反白 #黃昭瑜醫師

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現職 長庚醫院皮膚部 專任主治醫師 長庚醫院 皮膚外科 醫師 長庚診所與美容中心 專任主治醫師 長庚醫學院與化妝品系 皮膚科講師 長庚白斑治療中心 主任 經歷 長庚大學臨床研究所 博士進修 台北醫學大學 醫學士 美國麻省大學 University of Massachusetts 白斑中心 進修 加拿大艾伯塔大學 免疫所 研究員 新加坡National skin center 短期進修 學會與認證 台灣皮膚科醫學會會員 台灣皮膚暨美容外科醫學會會員 美國皮膚科醫學會會員 美國皮膚外科醫學會會員 歐洲皮膚科醫學會會員 著作 《黑斑白斑 有話要說》大塊文化出版社
專長: 白斑、色素移植、疤痕與蟹足腫治療、皮膚腫瘤手術、醫學美容(雷射、微整形) Specialized: Vitiligo, Melanocyte grafting, Scar and keloid, Skin tumor surgery, Aesthetic medicine (laser/injectable/botox)
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Mice given TNF-alpha and IFN-gamma developed the symptoms and organ damage of COVID-19 and died rapidly, Kanneganti said.

#70. Các thành phần tế bào của hệ thống miễn dịch - MSD Manuals

Tại các vị trí nhiễm trùng, các tế bào T kích hoạt tiết ra các cytokine (ví dụ, interferon-gamma[IFN-gamma]) và hiện tượng này dẫn đến sản xuất yếu tố ức ...

#71. El centro VISAVET de la Universidad Complutense de Madrid ...

Evaluation of the use of interferon-gamma (IFN-γ) test for the purpose of granting and retaining an official tuberculosis free herd status.

#72. IFN-γ - 快懂百科

1973年Younger和Salvin发现来自淋巴细胞培养上清中存在一种IFN，但抗原性不同于发现的IFN，遂命名Ⅱ型IFN，1980年统一命名为γ干扰素。

#73. Summary of the Public Assessment Report for COVID-19 ...

... a Th1 pattern of response (e.g. production of IFN-γ) were observed. ... with a concurrent interferon-γ (IFNγ)+ CD8+ T cell response.

#74. Stratégie de vaccination contre la Covid-19 - Haute Autorité ...

indiquent toute combinaison de IFN-γ, IL-2 et TNF, les carrés bleus indiquent IFN-γ, les triangles verts indiquent IL-2, et les losanges ...

#75. I risultati dello studio di Fase 3 che ha messo a confrotno il ...

... ha indotto ampie cellule T che producono IFN-gamma antigene-specifiche reattive contro S- (74,3%), N- (45,9%) e M- (20,3%) proteina.

#76. Interferon injection

Interferon beta is better tolerated than interferon alfa. g. Rebif® is a medication manufactured by a biotechnological process from one of the ...

#77. Interferon Gamma - EcuRed

De hecho, el IFN gamma puede influir sobre la clase de anticuerpo que es producido por los linfocitos B en el marco de una respuesta inmune. La inducción de ...

#78. Antibodies.com | LinkedIn

... fomite, and airborne exposure in Syrian hamsters; citing our hamster ELISA kits for IFN gamma (A74292), IL-6 (A75096), IL-4 (A74027), IL-10 (A74590), ...

#79. Protective activity of mRNA vaccines against ancestral and ...

1C to G). ... After peptide stimulation ex vivo and staining for intracellular interferon (IFN)-γ production, we detected a robust CD8 + T ...

#80. Fat, miscalibrated : Seek - Rockefeller University

The scientists found that TYK2-associated vulnerability to TB is caused by low levels of gamma interferon, a blood protein that usually protects the body ...

#81. version 28.12.2020 (LP-006395-110820, with amend. 1 ... - FDA

statistically significant increase in the secretion of IFN-gamma). The protective antibody titer is currently unknown.

#82. Test za određivanje stanične imunosti na SARS-CoV-2 - Sv ...

Pri tom dolazi do oslobađanja interferona-gama čija se koncentracija mjeri metodom ELISA (Euroimmun Interferon-gamma). Na temelju rezultata dobivenih u ...

#83. Athersys (ATHX) Reports Publication of Data from Placebo ...

... in pro-inflammatory cytokines IL-1beta, TNFα, IL-6, IFN-gamma and IL-2, have been observed following treatment for ischemic stroke.

#84. Report of Placebo-Controlled Clinical Trial ... - Stockhouse

... in pro-inflammatory cytokines IL-1beta, TNFa, IL-6, IFN-gamma and IL-2, have been observed following treatment for ischemic stroke.

#85. Periodontitis as an inflammatory trigger in hypertension

... along with key effector cytokines such as interleukin 6 (IL-6), TNF-alpha (TNF-α), interferon-gamma (IFN-γ), and interleukin 17 (IL-17).

#86. Palomar 4 linear

With this in mind, we employ the publicly available Fermi data to study the gamma-ray emission from ... accompanied by a downregulation of IFN-γ production.

#87. Athersys (ATHX) Stock: Why The Price Jumped Today

— Similar acute plasma biomarker responses to MultiStem, including decreases in pro-inflammatory cytokines IL-1beta, TNFα, IL-6, IFN-gamma and ...

#88. Cystic Fibrosis: Systems Biology Analysis from Homozygous p ...

... interferon-stimulated exonuclease gene 20 (ISG20) and hippocalcin-like ... viral RNAs as part of the interferon- (IFN-) regulated antiviral response [26.